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Deadly parasite threatens California sea otters
Melissa Miller knew something was off when she began to examine a sea otter that had died in San Simeon, a coastal California town about halfway between San Francisco and Los Angeles, in the winter of 2020. Nearly all of the animal’s body fat was inflamed. “It felt like there were little bumps all through it,” she says—a condition the veterinary pathologist had never seen in her 25 years examining sea otters for the California Department of Fish and Wildlife. She also found unusual lesions in the pancreas and heart. When Miller looked at the sea otter’s tissues under a microscope, she spotted a familiar foe:...
Source: ScienceNOW - March 22, 2023 Category: Science Source Type: news

News at a glance: Earth ’s top geological sites, cameras on sharks, and China’s space station
NATURAL HISTORY Science society lists Earth’s top ‘geoheritage’ sites The International Union of Geological Sciences last week marked its 60th anniversary by announcing a list of 100 “geoheritage” sites that have substantially influenced understanding of Earth’s deep history . The global list, released in collaboration with UNESCO, is meant to foster conservation and tourism. The sites include familiar ones, such as the Grand Canyon’s “great unconformity,” a billion-year gap in the rock record erased by erosion. More exotic examples include limestones in Germany that preserve Arc...
Source: Science of Aging Knowledge Environment - November 3, 2022 Category: Geriatrics Source Type: research

Progress in Anisakis Allergy Research: Milestones and Reversals
AbstractPurpose of the reviewAnisakis has gained cosmopolitan celebrity mainly through its potential to induce allergic disease. In the last two decades, several regions in the world, including the Mediterranean region, Japan, or Korea have reported high numbers of Anisakiasis-accompanied allergic symptoms: Gastro-allergic Anisakiasis.Recent findingsRecent wide-scale epidemiological studies highlight the global scenario ofAnisakis for human health, and awareness is the main contributing factor. After two decades of research in the field ofAnisakis allergy, in the last years, molecular studies ofAnisakis allergens including...
Source: Current Treatment Options in Allergy - September 9, 2020 Category: Allergy & Immunology Source Type: research

Clinical Management of Seafood Allergy
Publication date: January 2020Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 8, Issue 1Author(s): Carla M. Davis, Ruchi S. Gupta, Ozge N. Aktas, Veronica Diaz, Sandip D. Kamath, Andreas L. LopataSeafood plays an important role in human nutrition and health. A good patient workup and sensitive diagnostic analysis of IgE antibody reactivity can distinguish between a true seafood allergy and other adverse reactions generated by toxins or parasites contaminating ingested seafood. The 2 most important seafood groupings include the fish and shellfish. Shellfish, in the context of seafood consumption,...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 16, 2020 Category: Allergy & Immunology Source Type: research

Systems Biology Analysis of the Effect and Mechanism of Qi-Jing-Sheng-Bai Granule on Leucopenia in Mice
Conclusion In summary, our data reveal the therapeutic mechanism of QJSB by integrative application of transcriptomics-based network pharmacology and metabolomics technologies. QJSB exerts protective effect against leucopenia in mice through participating in multi-pathways, mainly including accelerating cell proliferation and differentiation, regulating metabolism response pathways and modulating immunologic function. Ethics Statement All animal studies were performed according to the institutional ethical guidelines of animal care and were approved by the Committee on the Ethics of Animal Experiments of the Second Mili...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Innate Lymphoid Cells in Helminth Infections —Obligatory or Accessory?
Conclusion ILC2s are clearly an inherent feature of the immune response to helminth infection, and in all probability their evolution has been driven by the threat of parasites. While in experimental model systems they are not always found to be essential, they are often center stage, particularly in the early phases of infection of each helminth system so far analyzed. They also form an important conceptual and mechanistic link with the allergic response that will allow us to understand in more detail the genesis and control of allergic disorders. In this respect, a much fuller analysis of ILC biology and function in the...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Human health, legislative and socioeconomic issues caused by the fish-borne zoonotic parasite Anisakis: challenges in risk assessment
ConclusionsVisual inspection (and candling) of fishery products as required by EU legislation is not efficient for parasite detection. Consequently, visible (and non-visible) Anisakis reach the market and may be detected (and eaten) by consumers. Marine fish appears to be the only industrial food product that is at high risk of containing parasites when placed on the market.Anisakiasis and allergy to Anisakis are hidden, underestimated emerging zoonoses worldwide. There is a need to better understand the impact of these zoonoses on individual health and particularly exposed human populations, and to assess the risk posed b...
Source: Trends in Food Science and Technology - February 9, 2019 Category: Food Science Source Type: research