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Infectious Disease: Adenoviruses

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Total 599 results found since Jan 2013.

LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung.
Abstract Hsp90 inhibitors were initially developed as anticancer agents; however it is becoming increasing clear that they also possess potent anti-inflammatory properties. Post-translational modifications of Hsp90 have been reported in tumors and have been hypothesized to affect client protein- and inhibitor-binding activities. In the present study we investigated the post-translational modification of Hsp90 in inflammation. LPS, a prototypical inflammatory agent, induced concentration- and time-dependent tyrosine (Y) phosphorylation of Hsp90α and Hsp90β in bovine pulmonary arterial and human lung microvascular...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 12, 2013 Category: Cytology Authors: Barabutis N, Handa V, Dimitropoulou C, Rafikov R, Snead CM, Kumar S, Joshi A, Thangjam G, Fulton DJ, Black SM, Patel V, Catravas JD Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

TR{alpha} Induces Reprogramming of Pancreatic Acinar Cells Gene Regulation
One goal of diabetic regenerative medicine is to instructively convert mature pancreatic exocrine cells into insulin-producing cells. We recently reported that ligand-bound thyroid hormone receptor α (TRα) plays a critical role in expansion of the β-cell mass during postnatal development. Here, we used an adenovirus vector that expresses TRα driven by the amylase 2 promoter (AdAmy2TRα) to induce the reprogramming of pancreatic acinar cells into insulin-producing cells. Treatment with l-3,5,3-triiodothyronine increases the association of TRα with the p85α subunit of phosphatidylinositol 3-kinase (PI3K), leading to th...
Source: Journal of Biological Chemistry - May 31, 2013 Category: Chemistry Authors: Furuya, F., Shimura, H., Asami, K., Ichijo, S., Takahashi, K., Kaneshige, M., Oikawa, Y., Aida, K., Endo, T., Kobayashi, T. Tags: Cell Biology Source Type: research

LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung
Heat shock protein 90 (Hsp90) inhibitors were initially developed as anticancer agents; however, it is becoming increasing clear that they also possess potent anti-inflammatory properties. Posttranslational modifications of Hsp90 have been reported in tumors and have been hypothesized to affect client protein- and inhibitor-binding activities. In the present study we investigated the posttranslational modification of Hsp90 in inflammation. LPS, a prototypical inflammatory agent, induced concentration- and time-dependent tyrosine (Y) phosphorylation of Hsp90α and Hsp90β in bovine pulmonary arterial and human lung...
Source: AJP: Lung Cellular and Molecular Physiology - June 15, 2013 Category: Respiratory Medicine Authors: Barabutis, N., Handa, V., Dimitropoulou, C., Rafikov, R., Snead, C., Kumar, S., Joshi, A., Thangjam, G., Fulton, D., Black, S. M., Patel, V., Catravas, J. D. Tags: ARTICLES Source Type: research

EGFR Stimulates Osteoprogenitor Growth and Survival via EGR2 Gene Regulation
Maintaining bone architecture requires continuous generation of osteoblasts from osteoprogenitor pools. Our previous study of mice with epidermal growth factor receptor (EGFR) specifically inactivated in osteoblast lineage cells revealed that EGFR stimulates bone formation by expanding the population of mesenchymal progenitors. EGFR ligands are potent regulators for the osteoprogenitor pool, but the underlying mechanisms are largely unknown. Here we demonstrate that activation of EGFR increases the number of osteoprogenitors by promoting cell proliferation and suppressing either serum depletion-induced or TNFα-induced apo...
Source: Journal of Biological Chemistry - July 12, 2013 Category: Chemistry Authors: Chandra, A., Lan, S., Zhu, J., Siclari, V. A., Qin, L. Tags: Cell Biology Source Type: research

Par14 Enhances IRS-1-mediated Insulin Signaling Signal Transduction
In this study, the association of Par14 with insulin receptor substrate 1 (IRS-1) was demonstrated in HepG2 cells overexpressing both as well as endogenously in the mouse liver. The analysis using deletion-mutated Par14 and IRS-1 constructs revealed the N-terminal portion containing the basic domain of Par14 and the two relatively C-terminal portions of IRS-1 to be involved in these associations, in contrast to the WW domain of Pin1 and the SAIN domain of IRS-1. Par14 overexpression in HepG2 markedly enhanced insulin-induced IRS-1 phosphorylation and its downstream events, PI3K binding with IRS-1 and Akt phosphorylation. I...
Source: Journal of Biological Chemistry - July 12, 2013 Category: Chemistry Authors: Zhang, J., Nakatsu, Y., Shinjo, T., Guo, Y., Sakoda, H., Yamamotoya, T., Otani, Y., Okubo, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Tsuchiya, Y., Kamata, H., Iwashita, M., Nishimura, F., Katagiri, H., Takahashi, S.-i., Kurihara, H., Uchida, T., As Tags: Metabolism Source Type: research

Transcription factor Kruppel-like factor 2 plays a vital role in endothelial colony forming cells differentiation
Conclusion Up-regulation of KLF2 by AMPK activation constitutes a novel mechanism of ECFC differentiation, and may have therapeutic value in the treatment of ischaemic heart disease.
Source: Cardiovascular Research - July 22, 2013 Category: Cardiology Authors: Song, Y., Li, X., Wang, D., Fu, C., Zhu, Z., Zou, M.-H., Zhu, Y. Tags: Vascular biology Source Type: research

Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells.
Abstract Although BMP9 is highly capable of promoting osteogenic differentiation of mesenchymal stem cell (MSCs), the molecular mechanism involved remains to be fully elucidated. Here, we explore the possible involvement and detail role of JNKs (c-Jun N-terminal kinases) in BMP9-induced osteogenic differentiation of MSCs. It was found that BMP9 stimulated the activation of JNKs in MSCs. BMP9-induced osteogenic differentiation of MSCs was dramatically inhibited by JNKs inhibitor SP600125. Moreover, BMP9-activated Smads signaling was decreased by SP600125 treatment in MSCs. The effects of inhibitor are reproduced wi...
Source: BMB Reports - August 1, 2013 Category: Biochemistry Authors: Zhao YF, Xu J, Wang WJ, Wang J, He JW, Li L, Dong Q, Xiao Y, Duan XL, Yang X, Liang YW, Song T, Tang M, Zhao D, Luo JY Tags: BMB Rep Source Type: research

Caveolin and β1-integrin coordinate angiotensinogen expression in cardiac myocytes
Conclusion: Collectively, these studies indicate that lipid rafts/caveolae couple to Ao gene expression through a mechanism that involves β1-integrin and the differential actions of MAP kinase family members.
Source: International Journal of Cardiology - October 11, 2012 Category: Cardiology Authors: Hind Lal, Suresh K. Verma, Hao Feng, Honey B. Golden, Fnu Gerilechaogetu, Damir Nizamutdinov, Donald M. Foster, Shannon S. Glaser, David E. Dostal Tags: Original Articles Source Type: research

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells
Conclusion: The results of this study supported YB-1 based virotherapy as an attractive therapeutic strategy for GBM treatment which will be exploited further in multimodal treatment concepts.
Source: Journal of Translational Medicine - September 18, 2013 Category: Research Authors: Klaus MantwillUlrike NaumannJanina SeznecVroni GirbingerHermann LagePawel SurowiakDagmar BeierMichel MittelbronnJürgen SchlegelPer Holm Source Type: research

Abstract 47: Caveolin-1 is Critical for Abdominal Aortic Aneurysm Induced by Angiotensin II Oral Session VI: Concurrent B Vascular Remodeling and Dysfunction
In conclusion, Cav1 and presumably vascular caveolae microdomains appear to play a critical role in the formation of AAA by Ang II via regulation of the ADAM17/EGFR signaling and subsequent ER/oxidative stress.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Obama, T., Takayanagi, T., Crawford, K. J., Kobayashi, T., Rizzo, V., Eguchi, S. Tags: Oral Session VI: Concurrent B Vascular Remodeling and Dysfunction Source Type: research

Downregulation of Hepatic Stimulator Substance during the Early Phase of Liver Regeneration Inhibits E-cadherin Expression in Mice.
Abstract Hepatic stimulatory substance (HSS), which encodes a sulfhydryl oxidase enzyme, promotes liver regeneration (LR) and maintains the viability of hepatocytes. Surprisingly, we found that the levels of the HSS mRNA and expressed protein were both strongly repressed at 12h after a 70% partial hepatectomy (PH) in mice. Understanding the mechanism and effect of this extraordinary suppression can provide a novel path for exploring the molecular function of HSS during LR. We observed that the EGF levels in the serum were negatively correlated with HSS expression in regenerating livers. Treating primary mouse hepa...
Source: The International Journal of Biochemistry and Cell Biology - December 2, 2013 Category: Biochemistry Authors: Zhang H, Dong LY, Sun G, An W Tags: Int J Biochem Cell Biol Source Type: research

Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation.
In this study, we characterize the involvement of hypoxia and reactive oxygen species (ROS) generation in the antineoplastic mechanism of proopiomelanocortin (POMC) gene delivery in a mouse B16-F10 melanoma model in vivo and in vitro. Histological analysis revealed increased TUNEL-positive cells and enhanced hypoxic activities in melanoma treated with adenovirus encoding POMC (Ad-POMC) but not control vector. Because the apoptotic cells were detected mainly in regions distant from blood vessels, it was hypothesized that POMC therapy might render melanoma cells vulnerable to hypoxic insult. Using a hypoxic chamber or cobalt...
Source: Free Radical Biology and Medicine - January 8, 2014 Category: Biology Authors: Liu GS, Wu JC, Tsai HE, Dusting GJ, Chan EC, Wu CS, Tai MH Tags: Free Radic Biol Med Source Type: research

Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: Positive and negative effects.
Conclusion: hSNCA gene silencing with AAV-mir30-hSNCA has positive effects on forelimb behavior and SN DA neurons, which are compromised by inflammation and reduced TH expression, suggesting that AAV2/8-mir30-hSNCA-mediated gene silencing, although promising in vitro, is not a candidate for therapeutic translation for PD. PMID: 24463035 [PubMed - as supplied by publisher]
Source: Brain Research - January 21, 2014 Category: Neurology Authors: Khodr CE, Becerra A, Han Y, Bohn MC Tags: Brain Res Source Type: research

Silencing of Pellino1 improves post-infarct cardiac dysfunction and attenuates left ventricular remodelling in mice
Conclusions Our data demonstrate that Pellino1 plays an important role in the pathogenesis of MI. Targeting Pellino1 may ameliorate cardiac dysfunction and remodelling following MI.
Source: Cardiovascular Research - March 18, 2014 Category: Cardiology Authors: Wu, W., Hu, Y., Li, J., Zhu, W., Ha, T., Que, L., Liu, L., Zhu, Q., Chen, Q., Xu, Y., Li, C., Li, Y. Tags: Cardiac biology and remodelling Source Type: research