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Infectious Disease: Herpes

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Total 364 results found since Jan 2013.

Hypersensitivity syndrome development and human herpes virus 6 reactivation in patients with secondary vasculitis
This study assesses lymphocyte phenotypic characteristics and activation markers in patients with hypersensitivity syndrome and HHV6 reactivation due to secondary vasculitis.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Lishchuk-Yakymovych, I. Voznyak, O. Syzon, R. Pukalyak, O. Synenkyy, L. DuBuske Tags: P259 Source Type: research

Immunological features of active herpesviral infection in bronchial asthma
Viral infection is associated with the development of asthma. However, the role of Human Herpesviriuses (HHV) in chronic lung diseases remains obscure. In order to evaluate the patterns and immune response to HHV infection, we detected the levels of antiviral IgG and IgE-Abs to Herpes simplex virus type 1 (HSV1), Cytomegalovirus(CMV) and Epstein-Barr Virus(EBV) in patients with bronchial asthma(BA)of different severity using modified ELISA. For assessment the influence of HHV on autoreactivity, the levels of IgE and IgG4-Abs to a tissue Ags were estimated.Asthma patients have significantly enhanced frequency of seropositiv...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Konishcheva, A., Gervazieva, V. Tags: Allergy and immunology Source Type: research

Clinical Spectrum of Patients with Pathogenic Variant of STAT3 conferring Gain-of-Function: A Mimic of Autoimmune Lymphoproliferative Syndrome
Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder caused by defective fas-mediated apoptosis. Patients often present in childhood with lymphoproliferation, splenomegaly and multilineage cytopenias (Price et al. Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations. Blood 2014). Though mutations in the FAS gene account for the majority of cases, an estimated 20% of patients who have no defined genetic cause are classified as ALPS-U (Shah et al. Autoimmune lymphoproliferative syndrome: an update and review of the literature. Current allergy and asthma reports 20...
Source: Blood - November 21, 2018 Category: Hematology Authors: Constantine, G., Su, H., Folio, L., Milner, J., Rao, V. K. Tags: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Poster III Source Type: research

The microbiome and allergic diseases
That microbial infections can influence the development and severity of allergic diseases is well established. Examples include Staphylococcus aureus or herpes simplex infection in atopic dermatitis (AD) and various respiratory viral infections in asthma. Adults with AD have been found to have increased cutaneous, multiorgan, and system infections associated with considerable cost burden from hospitalization.1 The strong association of S aureus infection in AD has resulted in the frequent use of antibiotics for exacerbation of AD, even in the absence of overt skin infection.
Source: Annals of Allergy, Asthma and Immunology - January 9, 2019 Category: Allergy & Immunology Authors: Donald Y.M. Leung Tags: Perspective Source Type: research

Predictive factors for progression to chronicity or recurrence after the first attack of acute urticaria in preschool-age children.
CONCLUSIONS: Preschool-aged children with acute urticaria should be evaluated for infections at the time of admission. Patients with unknown etiology, negative Herpes virus serology, absence of atopic dermatitis, and long lasting urticaria should be followed up for chronicity and recurrence. PMID: 30904182 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - March 19, 2019 Category: Allergy & Immunology Authors: Cetinkaya PG, Soyer O, Esenboga S, Sahiner UM, Teksam O, Sekerel BE Tags: Allergol Immunopathol (Madr) Source Type: research

Experimental Analysis of Viral –Host Interactions
Experimental Analysis of Viral–Host Interactions Joseph Gillen and Aleksandra Nita-Lazar* Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States Viral and pathogen protein complexity is often limited by their relatively small genomes, thus critical functions are often accomplished by complexes of host and pathogen proteins. This requirement makes the study of host–pathogen interactions critical for the understanding of pathogenicity and virology. This review article discusses proteomic methods that offer a...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

Using the Self-Controlled Tree-Temporal Scan Statistic to Assess the Safety of Live Attenuated Herpes Zoster Vaccine.
Abstract The self-controlled tree-temporal scan statistic allows detection of potential vaccine- or drug-associated adverse events without pre-specifying the specific events or post-exposure risk intervals of concern. It thus opens a promising new avenue for safety studies. The method has been successfully used to evaluate the safety of two vaccines for adolescents and young adults, but its suitability to study vaccines for older adults had not been established. The current study applied the method to assess the safety of live attenuated herpes zoster vaccination during 2011-2017 in U.S. adults ≥ 60 years old, u...
Source: Am J Epidemiol - May 6, 2019 Category: Epidemiology Authors: Yih WK, Kulldorff M, Dashevsky I, Maro JC Tags: Am J Epidemiol Source Type: research

Use of Topical Steroids in Conjunctivitis: A Review of the Evidence
Conclusions: Corticosteroids, in combination with anti-infectives, could be a promising treatment option for acute conjunctivitis subject to development of further evidence on their effectiveness and safety in conjunctivitis treatment.
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Review Source Type: research

Shingrix for Herpes Zoster: A Review Shingrix for Herpes Zoster: A Review
This brief primer reviews the pathophysiology of herpes zoster, and summarizes the results of the clinical trials of Shingrex, the newly approved recombinant vaccine for HZ prevention.Skin Therapy Letter
Source: Medscape Allergy Headlines - October 14, 2019 Category: Allergy & Immunology Tags: Dermatology Journal Article Source Type: news

P235 treatment patterns of influenza and zoster vaccinations in patients prescribed mepolizumab
This study examines the prevalence and patterns of influenza and herpes zoster vaccination among patients treated with mepolizumab in the real-world.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: J. Llanos, J. Mao, M. Bogart, J. Silver, C. Blauer-Peterson, E. Hulbert, B. Hahn Source Type: research

M256 nk cell dysfunction presenting as recurrent atypical kawasaki disease
The patient presented twice with atypical Kawasaki disease (KD) with testing positive for adenovirus, Epstein-Barr virus (EBV) on first presentation with significant neutropenia. Second presentation also had significant neutropenia and testing positive for herpes simplex virus (HSV) with viremia triggering concern for immunodeficiency. Work-up revealed reduced natural killer (NK) cell function.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: L. Kaminsky, A. Horwitz, K. Diehl Source Type: research

M056 hsv transverse myelitis in a patient on mepolizumab
Mepolizumab is a monoclonal antibody that inhibits IL-5 indicated as a maintenance treatment for severe eosinophilic asthma. Reactivation of the herpes zoster virus is a known adverse reaction of the drug. Here we present a patient who developed HSV transverse myelitis secondary to his mepolizumab treatment for severe asthma.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: F. Osman, R. Dass, K. Dass Source Type: research

Eczema Herpeticum: Clinical and Pathophysiological Aspects
AbstractAtopic dermatitis (AD) is the most common chronic inflammatory skin disease in the world. AD is a complex pathology mainly characterized by an impaired skin barrier, immune response dysfunction, and unbalanced skin microbiota. Moreover, AD patients exhibit an increased risk of developing bacterial and viral infections. One of the most current, and potentially life-threatening, viral infection is caused by herpes simplex virus (HSV), which occurs in about 3% of AD patients under the name of eczema herpeticum (EH). Following a first part dedicated to the clinical features, virological diagnosis, and current treatment...
Source: Clinical Reviews in Allergy and Immunology - December 12, 2019 Category: Allergy & Immunology Source Type: research

Whole Genome Sequencing Analyses Identify SIDT2 Loss-of-function Mutations In Patients with Eczema Herpeticum
This study aimed to identify rare variants that are associated with AD patients with a history of recurrent EH (ADEH+).
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Lianghua Bin, Claire Malley, Patricia Taylor, Meher Preethi Boorgula, Sameer Chavan, Malaika Mathias, Nicholas Rafaels, Ingo Ruczinski, Brittany Richers, Kathleen Barnes, Donald Leung, Rasika Mathias Source Type: research

Live Herpes Zoster Vaccine Fails to Provide Long-Term Protection in RA Patients on Tofacitinib Live Herpes Zoster Vaccine Fails to Provide Long-Term Protection in RA Patients on Tofacitinib
The live herpes zoster vaccine does not provide reliable long-term protection in rheumatoid arthritis (RA) patients taking tofacitinib, a recent study suggests.Reuters Health Information
Source: Medscape Allergy Headlines - April 20, 2020 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news