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Infectious Disease: COVID-19

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Total 157 results found since Jan 2013.

Viruses, Vol. 12, Pages 1189: Are Viral Vectors Any Good for RNAi Antiviral Therapy?
m RNA interference (RNAi) represents a novel approach for alternative antiviral therapy. However, issues related to RNA delivery and stability have presented serious obstacles for obtaining good therapeutic efficacy. Viral vectors are capable of efficient delivery of RNAi as short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA). Efficacy in gene silencing for therapeutic applications against viral diseases has been demonstrated in various animal models. Rotavirus (RV) miR-7 can inhibit rotavirus replication by targeting the RV nonstructural protein 5. Viral gene silencing by targeting the RNAi ...
Source: Viruses - October 20, 2020 Category: Virology Authors: Kenneth Lundstrom Tags: Editorial Source Type: research

A Web-Based Platform on Coronavirus Disease-19 to Maintain Predicted Diagnostic, Drug, and Vaccine Candidates.
In this study, state-of-the-art techniques have been used for predicting the potential candidates for diagnostics and therapeutics. PMID: 33136473 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - November 3, 2020 Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

The SARS-CoV-2 receptor, Angiotensin converting enzyme 2 (ACE2) is required for human endometrial stromal cell decidualization.
Abstract The coronavirus disease 2019 (COVID-19) first appeared in December 2019 and rapidly spread throughout the world. The SARS-CoV-2 virus enters the host cells by binding to the angiotensin-converting enzyme (ACE2). Although much of the focus is on respiratory symptoms, recent reports suggest that SARS-CoV-2 can cause pregnancy complications such as pre-term birth and miscarriages; and women with COVID-19 had maternal vascular malperfusion and decidual arteriopathy in their placentas. Here, we report that ACE2 protein is expressed in both endometrial epithelial and stromal cells in the proliferative phase of ...
Source: Biology of Reproduction - November 18, 2020 Category: Reproduction Medicine Authors: Chadchan SB, Popli P, Maurya VK, Kommagani R Tags: Biol Reprod Source Type: research

Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis
In conclusion, these data suggest that MEK-ERK1/2 signaling pathway facilitates IBV infection, probably by promoting cell survival; meanwhile, induction of DUSP6 forms a negative regulation loop to restrict ERK1/2 signaling, correlated with increased apoptosis and reduced viral load. Consequently, components of the ERK pathway, such as MEK1/2 and DUSP6, represent excellent targets for the development of antiviral drugs.
Source: Veterinary Research - January 11, 2021 Category: Veterinary Research Source Type: research

Viruses, Vol. 13, Pages 270: Synthetic Messenger RNA-Based Vaccines: from Scorn to Hype
o In the race for a vaccine against SARS-CoV-2, the synthetic mRNA format has been shown to be the fastest one and proved to be safe and highly efficient, even at the very low dose of a few µg per injection. The mRNA vaccines are not new: vaccines that are based on attenuated mRNA viruses, such as Mumps, Measles, and Rubella, immunize by delivering their mRNAs into the cells of the vaccinated individual, who produces the viral proteins that then prime the immune response. Synthetic mRNA in liposomes can be seen as a modern, more refined, and thereby a safer version of those live attenuated RNA viruses. The anti-COVID-...
Source: Viruses - February 9, 2021 Category: Virology Authors: Steve Pascolo Tags: Review Source Type: research

RNAi Technology and Investigation on Possible Vaccines to Combat SARS-CoV-2 Infection
Appl Biochem Biotechnol. 2021 Apr 7. doi: 10.1007/s12010-021-03548-2. Online ahead of print.ABSTRACTCoronavirus disease of 2019 (COVID-19) pandemic, taking place globally, occurs as a result of the SARS-CoV-2 viral infection which has caused death of innumerable numbers of people and is responsible for a massive drop in the global economy. Millions of people are infected, and the death rate is also quite high in different countries. So, there is an urgent requirement of the invention of some effective and efficient drugs that can be effective against this deadly viral infection. The invention of new drugs and vaccine has b...
Source: Applied Biochemistry and Biotechnology - April 7, 2021 Category: Biochemistry Authors: Pratik Talukder Sounak Chanda Source Type: research

ASAP siRNA Therapeutics for the Therapy of COVID-19 and Other Coronaviruses
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.0c01239
Source: Molecular Pharmaceutics - May 4, 2021 Category: Drugs & Pharmacology Authors: Muhammad Imran Sajid, Muhammad Moazzam, Yeseom Cho, Shun Kato, Ava Xu, J. J. Way, Sandeep Lohan, and Rakesh K. Tiwari Source Type: research

Design of advanced siRNA therapeutics for the treatment of COVID-19
Publication date: Available online 8 May 2021Source: Meta GeneAuthor(s): Iman Niktab, Maryam Haghparast, Mohammad-Hossein Beigi, Timothy L. Megraw, Amirkianoosh Kiani, Kamran Ghaedi
Source: Meta Gene - May 10, 2021 Category: Genetics & Stem Cells Source Type: research

Viruses, Vol. 13, Pages 1593: Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19
kus Kuhlmann Cleavage of double-stranded RNA is described as an evolutionary conserved host defense mechanism against viral infection. Small RNAs are the product and triggers of post transcriptional gene silencing events. Up until now, the relevance of this mechanism for SARS-CoV-2-directed immune responses remains elusive. Herein, we used high throughput sequencing to profile the plasma of active and convalescent COVID-19 patients for the presence of small circulating RNAs. The existence of SARS-CoV-2 derived small RNAs in plasma samples of mild and severe COVID-19 cases is described. Clusters of high siRNA abundance ...
Source: Viruses - August 11, 2021 Category: Virology Authors: Claudius Grehl Christoph Schulthei ß Katrin Hoffmann Mascha Binder Thomas Altmann Ivo Grosse Markus Kuhlmann Tags: Brief Report Source Type: research

ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling via Elevating Suppressor of Cytokine Signaling 1
In this study, we discovered that ORF3a, an accessory protein of SARS-CoV-2, inhibited IFN-activated Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling via upregulating suppressor of cytokine signaling 1 (SOCS1), a negative regulator of cytokine signaling. ORF3a induced SOCS1 elevation in a dose- and time-dependent manner. RNAi-mediated silencing of SOCS1 efficiently abolished ORF3a-induced blockage of JAK/STAT signaling. Interestingly, we found that ORF3a also promoted the ubiquitin-proteasomal degradation of Janus kinase 2 (JAK2), an important kinase in IFN signaling. Silencing of SOCS1 ...
Source: Frontiers in Microbiology - September 28, 2021 Category: Microbiology Source Type: research

Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing
Acc Chem Res. 2021 Oct 20. doi: 10.1021/acs.accounts.1c00500. Online ahead of print.ABSTRACTConspectusSince the U.S. Food and Drug Administration (FDA) granted emergency use authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has attracted broad attention from the scientific community to investors. When delivered intracellularly, mRNA has the ability to produce various therapeutic proteins, enabling the treatment of a variety of illnesses, including but not limited to infectious diseases, cancers, and genetic diseases. Accordingly, mRNA holds significant therapeutic potential and provides a promis...
Source: Cell Research - October 20, 2021 Category: Cytology Authors: Min Qiu Yamin Li Hanan Bloomer Qiaobing Xu Source Type: research

Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets
Mol Syst Biol. 2021 Nov;17(11):e10260. doi: 10.15252/msb.202110260.ABSTRACTTremendous progress has been made to control the COVID-19 pandemic caused by the SARS-CoV-2 virus. However, effective therapeutic options are still rare. Drug repurposing and combination represent practical strategies to address this urgent unmet medical need. Viruses, including coronaviruses, are known to hijack host metabolism to facilitate viral proliferation, making targeting host metabolism a promising antiviral approach. Here, we describe an integrated analysis of 12 published in vitro and human patient gene expression datasets on SARS-CoV-2 i...
Source: Mol Biol Cell - October 28, 2021 Category: Molecular Biology Authors: Kuoyuan Cheng Laura Martin-Sancho Lipika R Pal Yuan Pu Laura Riva Xin Yin Sanju Sinha Nishanth Ulhas Nair Sumit K Chanda Eytan Ruppin Source Type: research

Potential inhibitors and plant based technology: An alternative approach to treat corona virus
Bioorg Chem. 2021 Nov 1;117:105460. doi: 10.1016/j.bioorg.2021.105460. Online ahead of print.ABSTRACTThe current pneumonia outbreak, which began in early December 2019 near Wuhan City, Hubei Province, China, is caused by a novel corona virus (CoV) known as '2019-nCoV' or '2019 novel corona virus or COVID-19' by the World Health Organization (WHO). Vaccines are available to prevent corona virus contagious infection or to reduce the viral load in body but virus is continuously mutating itself to infect people at severity. In this critical scenario this review provide a compiled study for techniques and tools that can be used...
Source: Bioorganic Chemistry - November 11, 2021 Category: Chemistry Authors: Sachin Sharma Chetana Suvalka None Bharti Manoj Joshi Ayush Bahuguna Source Type: research