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Total 40 results found since Jan 2013.
Epidemiological and genetic features of anti-3 ‑hydroxy-3-methylglutaryl-CoA reductase necrotizing myopathy: Single-center experience and literature review
CONCLUSION: In northern Spain, anti-HMGCR IMNM preferentially affects people over 50 years of age who are carriers of the HLA-DRB1*11 allele and take statins. Both low vitamin D levels and hypothyroidism may play a potential predisposing role in the development of this disease.PMID:35487805 | DOI:10.1016/j.ejim.2022.04.017
Source: European Journal of Internal Medicine - April 29, 2022 Category: Internal Medicine Authors: Diana Prieto-Pe ña Javier G Ocejo-Vinyals Joel Mazariegos-Cano Ana L Pelayo-Negro Sara Remuzgo-Mart ínez Fernanda Genre Alicia Garc ía-Dorta M ónica Renuncio-García V íctor M Martínez-Taboada Carmen Garc ía-Ibarbia Julio S ánchez-Martín Marcos L Source Type: research
Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction
Brown bowel syndrome (BBS) is an exceedingly rare condition usually associated with longstanding malabsorption of any etiology. As a result of vitamin E deficiency and subsequent mitochondrial degeneration due to oxidative stress induced by free radicals, lipofuscin granules accumulate in the smooth muscles of the gastrointestinal tract resulting in myopathy and dysmotility with underlying disease aggravation. The current study reports a BBS case in a 64-year-old female patient who had undergone jejunoileal bypass surgery as a bariatric procedure. The patient was admitted with signs of malabsorption and ileus in computed t...
Source: Case Reports in Gastroenterology - November 29, 2021 Category: Gastroenterology Source Type: research
Association Between Vitamin D and Statin-Related Myopathy: A Meta-analysis
ConclusionsThe present meta-analysis provides evidence that low 25OHD level is associated with statin-related myopathy and that exogenous vitamin D supplementation can improve statin-related muscular intolerance associated with low 25OHD level in most cases. Our findings may provide useful insight for the prevention and treatment of statin-related myopathy.
Source: American Journal of Cardiovascular Drugs - July 23, 2021 Category: Cardiology Source Type: research
Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma –Induced Cancer Cachexia
In this study, we investigated whether preemptive administration of NR ameliorated C26 adenocarcinoma–induced cancer cachexia and explored anti-cachexic mechanisms focused on the changes in muscle atrophy, cachexic inflammation, and catabolic catastrophe. Dietary intake of the NR-containing pellet diet significantly attenuated cancer cachexia in a mouse model. Starting with significant inhibition of cachexic factors, tumor necrosis factor alpha, and interleukin-6, NR significantly inhibited muscle-specific ubiquitin-proteasome ligases, such as atrogin-1, muscle RING-finger protein-1 (MuRF-1), mitofusin-2, and peroxisome ...
Source: Frontiers in Pharmacology - June 28, 2021 Category: Drugs & Pharmacology Source Type: research
Intracranial Hemorrhage Secondary to Vitamin K Deficiency in X-linked Myotubular Myopathy
X-linked myotubular myopathy (XLMTM) is a congenital, centronuclear myopathy presenting at birth with facial anomalies, profound hypotonia, and respiratory muscle weakness leading to early respiratory failure. It is a rare disorder, estimated at 1 in 50,000 male births with a high mortality and modest 1-year survival between 25-64% [1-3]. While definitive data are not known, one study found that patients often died at around 7 years of age secondary to respiratory failure [1]. Patients with XLMTM typically experience multiple co-morbidities requiring extensive supportive care [2,3].
Source: Neuromuscular Disorders - May 11, 2021 Category: Neurology Authors: Jeremy M. Neese, Sabrina Yum, Susan Matesanz, Leslie J. Raffini, Hilary B. Whitworth, Kathleen M. Loomes, Oscar H. Mayer, Alicia M. Alcamo Tags: Case report Source Type: research
Lessons Learned from Inherited Metabolic Disorders of Sulfur-Containing Amino Acids Metabolism
ABSTRACTThe metabolism of sulfur-containing amino acids (SAAs) requires an orchestrated interplay among several dozen enzymes and transporters, and an adequate dietary intake of methionine (Met), cysteine (Cys), and B vitamins. Known human genetic disorders are due to defects in Met demethylation, homocysteine (Hcy) remethylation, or cobalamin and folate metabolism, in Hcy transsulfuration, and Cys and hydrogen sulfide (H2S) catabolism. These disorders may manifest between the newborn period and late adulthood by a combination of neuropsychiatric abnormalities, thromboembolism, megaloblastic anemia, hepatopathy, myopathy, ...
Source: Journal of Nutrition - October 1, 2020 Category: Nutrition Source Type: research
Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape.
In conclusion, these findings suggested that moderate vitamin D supplementation rescued simvastatin induced myopathy via improving the mitochondrial cristae shape and function.
PMID: 32479918 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - May 28, 2020 Category: Toxicology Authors: Ren L, Xuan L, Han F, Zhang J, Gong L, Lv Y, Zhang W, Yang S, Xu B, Yan Y, Guo L, Liu H, Wan Z, Liu L Tags: Toxicol Appl Pharmacol Source Type: research
Effect of Vitamin D Analogue on Rosuvastatin-Induced Myopathy in Wistar Rats.
Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy. The serum CK levels are comparable to the control group on day 15 of vitamin D administration.
PMID: 32292293 [PubMed - in process]
Source: The Scientific World Journal - April 16, 2020 Category: Science Tags: ScientificWorldJournal Source Type: research
An overview of statin-induced myopathy and perspectives for the future.
Authors: Nikolic D, Banach M, Chianetta R, Luzzu LM, Pantea Stoian A, Diaconu CC, Citarrella R, Montalto G, Rizzo M
Abstract
Introduction: Statins remain the most commonly prescribed lipid-lowering drug class for the treatment of atherosclerotic cardiovascular disease. Their well-recognized side effects are known as statin-associated muscle symptom (SAMS). Some advances in this field have been made in recent years, but the understanding of the mechanisms has lagged. Investigating the specific role of the anti-HMGCR autoantibody, pharmacokinetic genetic variants, characterization of the known phenotypes of statin to...
Source: Expert Opinion on Drug Safety - April 3, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Vitamin D serum level in subjects with critical illness polyneuropathy and myopathy.
CONCLUSION: Almost all subjects showed Vitamin D deficiency. No difference was detected between those with and without CIPNM. The condition might represent a secondary phenomenon resulting from the inflammatory process as well as from conditions that could interfere with vitamin D metabolism.
PMID: 32131367 [PubMed - in process]
Source: Journal of Musculoskeletal Neuronal Interactions - March 6, 2020 Category: Neurology Tags: J Musculoskelet Neuronal Interact Source Type: research
Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain.
Conclusion: We found a correlation between vitamin D deficiency and SAMS. Therefore, vitamin D levels may be useful for the diagnosis and management of SAMS.
PMID: 31019583 [PubMed - in process]
Source: Disease Markers - April 26, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Cardiovascular Health in Children and Adolescents With Congenital Adrenal Hyperplasia Due to 21-Hydroxilase Deficiency
Conclusions
Increasing evidence indicates that CAH individuals are prone to develop a number of early CV risk factors, such as obesity, hypertension, insulin resistance, low-grade inflammation, increased IMT and subclinical cardiac dysfunction, already in childhood.
The therapeutic management of patients with CAH remains a challenge and current treatment regimens do not always allow optimal biochemical control. Overexposure to glucocorticoids and mineralocorticoids as well as to androgens may contribute to the development of unfavorable metabolic and CV changes, even though metabolic derangement in CAH patients may also ...
Source: Frontiers in Endocrinology - April 10, 2019 Category: Endocrinology Source Type: research
A descriptive pilot study of mitochondrial mutations & clinical phenotype in fibromyalgia syndrome.
A descriptive pilot study of mitochondrial mutations & clinical phenotype in fibromyalgia syndrome.
Indian J Med Res. 2019 Jan;149(1):47-50
Authors: Danda S, Thomas BM, Paramasivam G, Thomas R, Mathew J, Danda D
Abstract
Background & objectives: : Fibromyalgia syndrome (FMS) is one of the most common chronic pain conditions of unknown aetiology. Mitochondrial dysfunction has been reported in FMS with some studies reporting the presence of mitochondrial mutation namely A3243G, which also causes mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes. This pilot study was condu...
Source: Indian J Med Res - December 31, 2018 Category: Research Authors: Danda S, Thomas BM, Paramasivam G, Thomas R, Mathew J, Danda D Tags: Indian J Med Res Source Type: research
