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Total 83 results found since Jan 2013.

Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hind Limbs of Chronic Hypoglycaemic Rats
In conclusion, the results suggest that peripheral neuropathy induced by IIH progresses proximo‐distally, that severity and incidence increase with duration of the hypoglycaemia, and that these changes are partially reversible within four weeks. Furthermore, IIH‐induced myopathy is most likely secondary to the neuropathy. This article is protected by copyright. All rights reserved.
Source: Basic and Clinical Pharmacology and Toxicology - August 16, 2017 Category: Drugs & Pharmacology Authors: Vivi F. H. Jensen, Anne ‐Marie Molck, Henrik Soeborg, Jette Nowak, Melissa Chapman, Jens Lykkesfeldt, Ingrid B. Bogh Tags: Original Article Source Type: research

Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice.
The objective of this study was to explore the potential underlying molecular mechanisms involved in normalizing diabetes-related changes in hyperglycaemia via pancreas apoptosis and muscle injury induced by multiple low-dose STZ (MLD-STZ) injection in response to dietary supplementation with CA. To induce the MLD-STZ diabetic mice, the C57BL/6J mice were intraperitoneally injected with STZ (50 mg/kg body weight) for consecutive five days. CA (60 mg/kg/d) was supplemented in drinking water for 4 weeks. Compared with control, CA inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an incre...
Source: Food and Chemical Toxicology - June 24, 2017 Category: Food Science Authors: Zhu D, Zhang X, Niu Y, Diao Z, Ren B, Li X, Liu Z, Liu X Tags: Food Chem Toxicol Source Type: research

Effects of different aerobic exercise frequencies on streptozotocin –nicotinamide‐induced type 2 diabetic rats: Continuous versus short bouts and weekend warrior exercises
ConclusionsThe results of the study emphasize the effects of training on inflammation, increased oxidative stress, myopathy, and mitochondrial damage in a rat model of T2DM, and demonstrate that there is no major difference between exercise modalities provided that the total duration of exercise remains the same.
Source: Journal of Diabetes - June 2, 2017 Category: Endocrinology Authors: Nuray Alaca, Serap Uslu, Guldal Gulec Suyen, Umit Ince, Mustafa Serteser, H ızır Kurtel Tags: Original Article Source Type: research

Clinical spectra of neuromuscular manifestations in patients with lipodystrophy: a multicenter study
• Lipodystrophies are associated with a wide spectrum of neuromuscular abnormalities.• Peripheral sensorimotor neuropathy and muscle symptoms are common in lipodystrophy.• Overt myopathy with elevated CK levels is a distinctive characteristic of CGL4.• Neuromuscular abnormalities can be asso ciated with serious morbidity.• Accumulation of triglycerides in muscles contributes to insulin resistance.
Source: Neuromuscular Disorders - June 1, 2017 Category: Neurology Authors: Gulcin Akinci, Haluk Topaloglu, Tevfik Demir, Ayca Ersen Danyeli, Beril Talim, Fatma Ela Keskin, Pinar Kadioglu, Enez Talip, Canan Altay, Guzin Fidan Yaylali, Habib Bilen, Banu Nur, Leyla Demir, Huseyin Onay, Baris Akinci Source Type: research

Dexamethasone Treatment at the Myoblast Stage Enhanced C2C12 Myocyte Differentiation.
Discussion: This novel finding contributed to the explanation on the stage-specific mechanism of glucocorticoid-induced myopathy. A new formula for myoblast differentiation, containing both DEX and insulin, is proposed. Further research is required to understand the complete mechanism of DEX-induced muscle hypertrophy. PMID: 28539819 [PubMed - in process]
Source: International Journal of Medical Sciences - May 26, 2017 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Effects of different aerobic exercise frequencies on  streptozotocin‐nicotinamide‐induced type 2 diabetic rats: continuous versus short bouts and weekend warrior exercises
ConclusionsThe results of our study emphasized the impact of training on inflammation, increased oxidative stress, myopathy and mitochondrial damage in the rat model of streptozotocin‐nicotinamide‐induced T2DM, and demonstrated that there is no major difference between exercise modalities provided that the total duration of exercise remains the same.
Source: Journal of Diabetes - April 20, 2017 Category: Endocrinology Authors: Nuray Alaca, Serap Uslu, Guldal Gulec Suyen, Umit Ince, Mustafa Serteser, H ızır Kurtel Tags: Original Article Source Type: research

Kidney involvement in MELAS syndrome: Description of 2 cases.
CONCLUSION: The presence of FSGS or other kidney involvement accompanied by hereditary neurosensory deafness and T2DM could be suggestive of a A3243G tRNA(Leu) mutation and should prompt a genetic testing and an evaluation of potential extrarenal involvement. PMID: 28283275 [PubMed - as supplied by publisher]
Source: Medicina Clinica - March 12, 2017 Category: Journals (General) Tags: Med Clin (Barc) Source Type: research

Kasuistik: Late-onset Small-Fiber-Neuropathie nach kritischer Erkrankung.
Abstract A 42-year-old patient presented with acute allodynia and hyperalgesia in her distal limbs, most severe in the innervation area of the ulnar nerve. The patient developed critical illness myopathy/polyneuropathy after septic shock 5 months prior to her presentation. After exclusion of differential diagnosis, "late onset small fiber neuropathy" after critical illness was diagnosed. Recent studies showed small fiber lesions during critical illness and in follow-up exams, where additionally neuropathic pain were proved. Dysfunction of voltage-gated Sodium channels related to severe insulin resistance during cr...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - February 28, 2017 Category: Intensive Care Authors: Koch S, Moshourab R, Wollersheim T, Spies C, Fritzsche T, Weber-Carstens S Tags: Anasthesiol Intensivmed Notfallmed Schmerzther Source Type: research

Potential role for the VDR agonist elocalcitol in metabolic control: Evidences in human skeletal muscle cells
Publication date: March 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology, Volume 167 Author(s): Cristina Antinozzi, Clarissa Corinaldesi, Carla Giordano, Annalinda Pisano, Bruna Cerbelli, Silvia Migliaccio, Luigi Di Luigi, Katia Stefanantoni, Gabriella Barbara Vannelli, Salvatore Minisola, Guido Valesini, Valeria Riccieri, Andrea Lenzi, Clara Crescioli Vitamin D plays a pivotal role to maintain skeletal muscle integrity and health. Vitamin D deficiency characterizes inflammatory myopathy (IM) and diabetes, often overlapping diseases involving skeletal muscle damage. Vitamin D receptor (VDR) agonists l...
Source: The Journal of Steroid Biochemistry and Molecular Biology - February 2, 2017 Category: Biochemistry Source Type: research

Pharmacometabolomic signature links simvastatin therapy and insulin resistance
ConclusionWithin this short 6  weeks study, some patients became hyperglycemic and/or insulin resistant. Diabetic markers were associated with decarboxylated small aminated metabolites as well as a branched chain amino acid directly linked to glucose metabolism and fatty acid biosynthesis. Pharmacometabolomics provides powerful tools for precision medicine by predicting development of drug adverse effects in sub populations of patients. Metabolic profiling prior to start of drug therapy may empower physicians with critical information when prescribing medication and determining prognosis.
Source: Metabolomics - December 22, 2016 Category: Biology Source Type: research

A novel mutation in mitochondrial DNA in a patient with diabetes, deafness and proteinuria.
We report on a 28-year-old Caucasian woman with a history of diabetes, kidney disease, deafness, diarrhoea, myopathy and fatigue. The diagnosis of mitochondrial disease was made in this patient, which resulted from a novel 09155A>G mutation in the mtDNA. As far as we know, this mutation has never been described before as causing MIDD. PMID: 27966441 [PubMed - in process]
Source: The Netherlands Journal of Medicine - November 30, 2016 Category: Journals (General) Authors: Adema AY, Janssen MC, van der Heijden JW Tags: Neth J Med Source Type: research

Homozygous LIPE mutation in siblings with multiple symmetric lipomatosis, partial lipodystrophy, and myopathy
Despite considerable progress in identifying causal genes for lipodystrophy syndromes, the molecular basis of some peculiar adipose tissue disorders remains obscure. In an Israeli–Arab pedigree with a novel autosomal recessive, multiple symmetric lipomatosis (MSL), partial lipodystrophy and myopathy, we conducted exome sequencing of two affected siblings to identify the disease‐causing mutation. The 41‐year‐old female proband and her 36‐year‐old brother reported marked accumulation of subcutaneous fat in the face, neck, axillae, and trunk but loss of subcutaneous fat from the lower extremities and progressive d...
Source: American Journal of Medical Genetics Part A - November 10, 2016 Category: Genetics & Stem Cells Authors: Sagit Zolotov, Chao Xing, Riad Mahamid, Adel Shalata, Mohammed Sheikh ‐Ahmad, Abhimanyu Garg Tags: Clinical Report Source Type: research

Pathogenic phenotype of adipogenesis and hyaluronan in orbital fibroblasts from female Graves' orbitopathy mouse model.
In conclusion, mOFs established from GO model recapitulate the pathogenicity of human OFs from GO patients by their increased propensity for adipogenesis and hyaluronan production leading to disease activity. To our knowledge, this is the first report to show mOFs from the preclinical GO model have pathogenic properties that will aid in understanding the molecular and genetic changes during progression to adipogenesis and hyaluronan deposition to provide new insights into GO pathogenesis. PMID: 27552248 [PubMed - as supplied by publisher]
Source: Endocrinology - August 22, 2016 Category: Endocrinology Authors: Görtz GE, Moshkelgosha S, Jesenek C, Edelmann B, Horstmann M, Banga JP, Eckstein A, Berchner-Pfannschmidt U Tags: Endocrinology Source Type: research

Muscle redox disturbances and oxidative stress as pathomechanisms and therapeutic targets in early-onset myopathies
Publication date: Available online 12 August 2016 Source:Seminars in Cell & Developmental Biology Author(s): Maryline Moulin, Ana Ferreiro Because of their contractile activity and their high oxygen consumption and metabolic rate, skeletal muscles continually produce moderate levels of reactive oxygen and nitrogen species (ROS/RNS), which increase during exercise and are buffered by multiple antioxidant systems to maintain redox homeostasis. Imbalance between ROS/RNS production and elimination results in oxidative stress (OxS), which has been implicated in aging and in numerous human diseases, including cancer, di...
Source: Seminars in Cell and Developmental Biology - August 11, 2016 Category: Cytology Source Type: research

Glucocorticoids and 11{beta}-HSD1 are major regulators of intramyocellular protein metabolism
The adverse metabolic effects of prescribed and endogenous glucocorticoid excess, ‘Cushing’s syndrome’, create a significant health burden. While skeletal muscle atrophy and resultant myopathy is a clinical feature, the molecular mechanisms underpinning these changes are not fully defined. We have characterized the impact of glucocorticoids upon key metabolic pathways and processes regulating muscle size and mass including: protein synthesis, protein degradation, and myoblast proliferation in both murine C2C12 and human primary myotube cultures. Furthermore, we have investigated the role of pre-receptor m...
Source: Journal of Endocrinology - June 22, 2016 Category: Endocrinology Authors: Morgan, S. A., Hassan-Smith, Z. K., Doig, C. L., Sherlock, M., Stewart, P. M., Lavery, G. G. Tags: Research Source Type: research