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Drug: Tetracycline

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Total 6458 results found since Jan 2013.

Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL
Conclusion:Although RUNX1 mutations found in AML patient may not be essential for the hyperproliferative and growth phenotype of the AML, they play a causal role in maintaining myeloid lineage restriction, expansion and chemo-resistance. Correction or removal of the RUNX1 mutation in AML cells leads to a disease switch from AML to B-ALL, effectively changing the difficult-to-treat drug-resistant AML to another disease with more favorable CR (B-ALL).DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Wang, C., Hayashi, Y., Cai, X., Yan, X., Huang, G., Zheng, Y. Tags: 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Poster I Source Type: research

Omadacycline: A New Tetracycline Antibiotic.
CONCLUSION: Omadacycline is an alternative treatment option for ABSSSI and CABP. PMID: 30917674 [PubMed - in process]
Source: The Annals of Pharmacotherapy - March 29, 2019 Category: Drugs & Pharmacology Authors: Dougherty JA, Sucher AJ, Chahine EB, Shihadeh KC Tags: Ann Pharmacother Source Type: research

Identification of a nth-Like Gene Encoding an Endonuclease III in Campylobacter jejuni
In this study, a BER homolog encoded by cj0595c (named nth) in C. jejuni was analyzed for endonuclease III activity and for its role in maintaining genomic stability. It was found that inactivation of nth resulted in elevated frequencies of spontaneous fluoroquinolone-resistant (FQR) and oxidative stress resistant (OXR) mutants, compared with the wild-type strain in C. jejuni. Sequencing analysis of the FQR and OXR mutants revealed that the elevated mutation rates were associated with C → T or G → A transition in gyrA (FQR mutants) or perR (for OXR mutants). In an in vitro assay, a purified recombinant C. jej...
Source: Frontiers in Microbiology - April 9, 2019 Category: Microbiology Source Type: research

Microbiota of the Gut-Lymph Node Axis: Depletion of Mucosa-Associated Segmented Filamentous Bacteria and Enrichment of Methanobrevibacter by Colistin Sulfate and Linco-Spectin in Pigs
This study aimed to characterize shifts in microbial community structure across the intestinal mucosa-enteric lymph node axis in order to understand the effects of two commonly used antibiotics (Linco-Spectin and Colistin sulfate; oral application). We hypothesized that these antibiotics influence GI microbiota diversity and community structure and that, as a result, the ICLN-ileum axis is altered through permeability changes and changed translocation patterns. Medicated-feed antibiotics are still heavily used, not only in the E.U. but worldwide in case of infections. In addition to the taxonomic community profiling survey...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Microbial Diversity and Antimicrobial Resistance Profile in Microbiota From Soils of Conventional and Organic Farming Systems
According to this study it may be outlined that soil microbiota is a stable component as it were detected similar composition of microorganisms in soil both in organic as well as in conventional farming systems with similar soil structure and pH. The different amount of phosphorus in soils had no influence on bacterial variety at a genera level although more investigations would be useful to investigate changes among separate species. During evolution microorganisms adapted to survive in ecosystems independently of certain changes and probably serve as a buffer for ecological niches. It is unclear, however, what level of i...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research

Head-to-head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease.
CONCLUSIONS: It is not clear from the evidence included in this review whether there is a difference in efficacy or safety between different classes or regimens of prophylactic antibiotic, given for 12 to 13 weeks to people with COPD. Whilst no head-to-head comparisons of antibiotic resistance were identified, concerns about this continue. The sample size in this review is small and both included studies are of short duration. Thus, there is considerable uncertainty in effects observed and the effects of different prophylactic antibiotics requires further research. PMID: 31125127 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 23, 2019 Category: General Medicine Authors: Threapleton CJ, Janjua S, Fortescue R, Baker EH Tags: Cochrane Database Syst Rev Source Type: research

Antibiotics for trachoma.
CONCLUSIONS: Antibiotic treatment may reduce the risk of active trachoma and ocular infection in people infected with C trachomatis, compared to no treatment/placebo, but the size of the treatment effect in individuals is uncertain. Mass antibiotic treatment with single dose oral azithromycin reduces the prevalence of active trachoma and ocular infection in communities. There is no strong evidence to support any variation in the recommended periodicity of annual mass treatment. There is evidence of an increased risk of antibiotic resistance at 12 months in communities treated with antibiotics. PMID: 31554017 [PubMed ...
Source: Cochrane Database of Systematic Reviews - September 25, 2019 Category: General Medicine Authors: Evans JR, Solomon AW, Kumar R, Perez Á, Singh BP, Srivastava RM, Harding-Esch E Tags: Cochrane Database Syst Rev Source Type: research

Prevalence of fluoroquinolone-resistant Salmonella serotypes in Iran: a meta-analysis.
Authors: Khademi F, Vaez H, Ghanbari F, Arzanlou M, Mohammadshahi J, Sahebkar A Abstract The present study was conducted to investigate the antimicrobial susceptibility profiles of Salmonella serotypes, especially fluoroquinolone-resistant strains, recovered from clinical samples in Iran. A full electronic search using related keywords was conducted in Persian and English languages in ISI Web of Knowledge, PubMed, Scopus, Google Scholar and the Scientific Information Database (SID) search engines to find papers published between 1983 and 1 July 2019. According to the inclusion and exclusion criteria, 46 eligible ar...
Source: Pathogens and Global Health - February 7, 2020 Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research

Brief Report: Cessation of Long-Term Cotrimoxazole Prophylaxis in HIV-Infected Children Does Not Alter the Carriage of Antimicrobial Resistance Genes
Conclusions: No differences were observed in resistance gene carriage between the stop and continue groups. The previously shown multi-faceted protective effects of CTX in antiretroviral research for Watoto trial clinical outcomes are not outweighed by the risk of multi-drug resistance gene selection due to prophylaxis. These findings are reassuring, given current recommendations for long-term CTX prophylaxis among children living with HIV in sub-Saharan Africa to decrease mortality and morbidity.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - November 18, 2020 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Prophylactic antibiotics for adults with chronic obstructive pulmonary disease: a network meta-analysis.
CONCLUSIONS: This NMA evaluated the safety and efficacy of different antibiotics used prophylactically for COPD patients. Compared to placebo, prolonged administration of macrolides (ranked first) appeared beneficial in prolonging the time to next exacerbation, improving quality of life, and reducing serious adverse events. No clear benefits were associated with use of quinolones or tetracyclines. In addition, antibiotic resistance was a concern and could not be thoroughly assessed in this review. Given the trade-off between effectiveness, safety, and risk of antibiotic resistance, prophylactic administration of antibiotic...
Source: Cochrane Database of Systematic Reviews - January 15, 2021 Category: General Medicine Authors: Janjua S, Mathioudakis AG, Fortescue R, Walker RA, Sharif S, Threapleton CJ, Dias S Tags: Cochrane Database Syst Rev Source Type: research

Phylogeny, Biofilm Production, and Antimicrobial Properties of Fecal Microbial Communities of Adi Tribes of Arunachal Pradesh, India
This study aimed to analyze the ethnic tribe's biofilm producing antibiotic resistant bacteria and their phyllogenetic analysis in 15 stool samples collected from Adi tribes of Arunachal Pradesh. Of the analyzed samples, 42.85% were Escherichia, 20% lactic acid bacteria, 20% Salmonella, and 17.14% Enterococcus. Escherichia coli, lactic acid bacteria, and Enterococcus sp. emerged as strong biofilm producers; however, Salmonella declined to exhibit characters for a strong biofilm producer. Tetracycline resistance dominated in all the gut bacterial profiles. The 16SrRNA amplified PCR product was used for sequencing, and a phy...
Source: Applied Biochemistry and Biotechnology - March 4, 2021 Category: Biochemistry Authors: Parijat Hazarika Indranil Chattopadhyay Mika Umpo Yashmin Choudhury Indu Sharma Source Type: research

EXPRESS: Uninterpretable cerebrospinal fluid absorbance scans caused by antibiotic therapy
Conclusions The problem of CSF absorbance curve interference might be more common than previously suspected. Due to the potential NBA- lowering effect of tetracyclines, the author recommends visual examination of CSF samples in every case.PMID:34120479 | DOI:10.1177/1177_00045632211027612
Source: Clinical Biochemistry - June 14, 2021 Category: Biochemistry Authors: Jan Miller Source Type: research

Uninterpretable cerebrospinal fluid absorbance scans caused by antibiotic therapy
CONCLUSIONS: The problem of cerebrospinal fluid absorbance curve interference might be more common than previously suspected. Due to the potential net bilirubin absorbance-lowering effect of tetracyclines, the author recommends visual examination of cerebrospinal fluid samples in every case.PMID:34210169 | DOI:10.1177/00045632211027612
Source: Clinical Biochemistry - July 2, 2021 Category: Biochemistry Authors: Jan Miller Source Type: research