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Total 118 results found since Jan 2013.

Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women
In conclusion, our findings suggest CRT is a critical intervention element that can significantly modulate circulating levels of adipokines. Interestingly, these effects were intensified when Zataria Multiflora supplementation added to CRT regimen, whereas ZM alone had little effects on measured adipokines. This implies that the beneficial effects of CRT on circulating levels of adipokines could be amplified with simultaneous intake of ZM; that is, they act synergistically. Consequently, CRT alone or its combination with ZM could be considered by researchers and health practitioners as a non-pharmacologic means to modulate...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Estrogen induce VEGF expression in dermal papilla cells
It is required to reveal the mechanisms of female pattern hair loss (FPHL) augmenting in Japanese women with age. Estrogen could have a pivotal role on the hair cycle control, because anagen extends during pregnancy. Estrogen levels in blood considerably drop in women who are in ages suffering FPHL. Therefore, we analyzed expressions of several genes associated with hair cycles using real time RT-PCR in human follicular dermal papilla cells (DPCs) after treatment with a various extent of estradiol. The cells were culture with serum-free medium without phenol red. We found that vascular endothelial growth factor (VEGF) expr...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Yuuki Sakurai, Ichitaro Niibe, Satoshi Ogawa, Yasufumi Takeda, Takashi Matsuzaki Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Anti-androgenic, anti-oestrogenic and antioxidant activities of aqueous extract of Laportea ovalifolia on adults rats.
Cancer is one of the most life-threatening diseases in which deregulating proliferation of abnormal cells invades and disrupts surrounding tissues. It constitutes seriouspublic health problems in both developed and developing countries.To evaluate the anti-androgenic, anti-estrogenic and antioxidant activities of Laportea ovalifolia (L. ovalifolia) in order to contribute to the search and the valorization of medicinal plants which could reduce mortality related to prostate cancer.The evaluation of the anti-androgenic activity were carried out on castrated male rats receiving simultaneous daily administration of testosteron...
Source: International Journal of Phytomedicine - June 18, 2016 Category: Science Authors: Sylvain Nguedia Njina Source Type: research

Natural Medicines for Psychotic Disorders: A Systematic Review
Patients with psychotic disorders regularly use natural medicines, although it is unclear whether these are effective and safe. The aim of this study was to provide an overview of evidence for improved outcomes by natural medicines. A systematic literature search was performed through Medline, PsycINFO, CINAHL, and Cochrane until May 2015. In 110 randomized controlled trials, evidence was found for glycine, sarcosine, N-acetylcysteine, some Chinese and ayurvedic herbs, ginkgo biloba, estradiol, and vitamin B6 to improve psychotic symptoms when added to antipsychotics. Ginkgo biloba and vitamin B6 seemed to reduce tardive d...
Source: The Journal of Nervous and Mental Disease - February 1, 2018 Category: Psychiatry Tags: Review Article Source Type: research

Add-on effect of Guizhi Fuling formula to mifepristone for endometriosis: A meta-analysis of randomized controlled trials
Conclusion: GZFL as adjuvant therapy to mifepristone appears to have additional benefits in preventing recurrence of endometriosis and improving pregnancy among women with endometriosis. However, these conclusions should be interpreted with caution due to the methodological flaws of the included trials.
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor-positive breast cancer: a systematic review and meta-analysis
CONCLUSIONS: CMH combined with complementary therapy can moderately reduce endocrine therapy-induced side effects, including bone loss and dyslipidemia in patients with HR + breast cancer, revealing the potential role of CMH in treating (HR+) breast cancer. More high-quality RCTs are warranted to further validate the effectiveness and safety of CMH.PMID:37096936 | DOI:10.1080/13880209.2023.2203193
Source: Pharmaceutical Biology - April 25, 2023 Category: Drugs & Pharmacology Authors: Shaoqing Chen Yifang Gao Haichao Liu Jin Jing Zhengyu Yang Haoming Zhu Bairui Chen Yu Wang Ting Zhang Shizhong Wang Jianping Lin Source Type: research

Abstract LB-086: Genes targeted by drugs and curcumin in a breast carcinogenesis model
Breast carcinogenesis is a multistage process that involves mutations and cellular phenotypic alterations attributed to exposure to exogenous environmental substances as well as endogenous agents as female hormones. Pamidronate (Pam), one of the nitrogen-containing bisphosphonates, is used in the treatment of bone metastases of breast cancer. It has recently been reported that it is also related to cell proliferation and apoptosis. 5-Fluorouracil (5-FU) is a chemotherapeutic agent for the treatment of a variety of solid cancers that arrest cell cycle and induce apoptosis in cancer cells. Curcumin (Cur) is an antioxidant kn...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Calaf, G. M., Roy, D., Ponce-Cusi, R. Tags: Carcinogenesis Source Type: research

Molecular imaging of tumor microenvironment to study synergistic effects of therapy with doxorubicin and CAMs
Conclusion: Although the treatment with black cohosh showed no therapeutic effect in our in vitro studies, we noticed significant changes in tumor metabolism and angiogenesis in vivo. The most intriguing finding was that the intake of BC alone was capable of changing the tumor microenvironment by increasing the metabolic rate and decreasing angiogenesis. More work remains to be done to further elucidate the therapeutic potential of BC and other CAMs with current chemotherapeutics. Research Support: Studies were funded by Arnold Beckman Foundation and the Ministry of Science and Higher Education Poland (Mobility Plus Program).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Hedhli, J., Konopka, C., Ploska, A., Schuh, S., Kalinowski, L., Dobrucka, I., Dobrucki, W. Tags: Oncology: Basic, Translational & amp; Therapy (Basic Science) Posters Source Type: research

Drynaria fortunei J. Sm. improves the bone mass of ovariectomized rats through osteocalcin-involved endochondral ossification
Conclusions This study shows that the WEK can translationally promote the bone mass in ovariectomized rats through stimulating OCN-involved endochondral ossification. Graphical abstract
Source: Journal of Ethnopharmacology - November 14, 2014 Category: Drugs & Pharmacology Source Type: research

Efficacy and Side-effects of a Semi-individualized Chinese Herb Mixture "Tiao Gēng Tāng" for Menopausal Syndrome in China
Conclusion: TGT alleviates menopausal symptoms with similar efficacy as tibolone but has fewer side effects.
Source: In Vivo - January 19, 2015 Category: Research Authors: JIA, M., KLUWE, L., LIU, H.-C., TANG, Q.-J., LIU, L., WANG, Z.-Z., TIAN, L.-X., ZHAO, L., CHEN, Y.-C., FRIEDRICH, R. E., SUN, Z.-J., XU, L.-W. Tags: Clinical Studies Source Type: research