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Drug: Metformin
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Total 8616 results found since Jan 2013.
Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
New insights on the potential anti-epileptic effect of metformin: Mechanistic pathway
In conclusion, metformin might be an adjuvant with AEAs in the management of refractory epilepsy. Preclinical and clinical studies are warranted in this regard.PMID:37737447 | DOI:10.1111/jcmm.17965
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Saud A Alnaaim Hayder M Al-Kuraishy Ali I Al-Gareeb Naif H Ali Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
Metformin Ameliorates Postoperative Cognitive Dysfunction through Regulation of the AMPK/SIRT1 Pathway
CONCLUSIONS: Through the AMPK/SIRT1 pathway, metformin can boost autophagy and reduce oxidative stress in cortical microglia in older rats, in turn improving postoperative cognitive function.PMID:37735113 | DOI:10.31083/j.jin2205110
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Peiyu Jia Ji Che Junfeng Zhang Haibing Li Quanhong Zhou Yong Guo Source Type: research
Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2259216. Online ahead of print.ABSTRACTCrizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with severe, sometimes fatal, cases of cardiac failure, which increases the risk of mortality. However, the underlying mechanism remains unclear, which causes the lack of therapeutic strategy. We established in vitro and in vivo models for crizotinib-induced cardiotoxicity and found that crizotinib caused left ventricular dysfunction, myocardial injury and p...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Zhifei Xu Zezheng Pan Ying Jin Zizheng Gao Feng Jiang Huangxi Fu Xueqin Chen Xiaochen Zhang Hao Yan Xiaochun Yang Bo Yang Qiaojun He Peihua Luo Source Type: research
The continued pursuit of the holy grail – a novel method for reducing the risk of aortic aneurysm growth
Dr Cheng and colleagues, in this edition of the Journal of Vascular Surgery, present a novel medication and delivery system to reduce the rate of growth of small abdominal aortic aneurysms (AAAs).1 Currently the only reliable method of preventing rupture of AAAs is aneurysm repair, by either open or endovascular means. Medical therapy to reduce risk of AAA rupture remains the “holy grail” of vascular disease. Several medications have been studied for this purpose, including metformin,2 beta adrenergic blockade and other antihypertensive medications including angiotensin receptor blockers and angiotensin converting enzy...
Source: Journal of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Peter J. Rossi Tags: Invited commentary Source Type: research
AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway
In this study, we found that activation of AMPK by AICAR and metformin inhibits foam cell formation via suppression of mTOR in macrophages. Specifically, activation of AMPK indirectly reduced the phosphorylation level of mTOR at Ser2448 and promoted the expression of cholesterol efflux transporters and cholesterol efflux. These inhibitory effects on foam cell formation were counteracted by mTOR activators. Metformin, a more nonspecific AMPK activator than AICAR, appears to inhibit foam cell formation via anti-inflammatory effects in addition to suppression of the mTOR pathway. The results of this study suggest that the dev...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Reina Owaki Hiromasa Aoki Kohki Toriuchi Yasumichi Inoue Hidetoshi Hayashi Satoru Takeshita Hiroki Kakita Yasumasa Yamada Mineyoshi Aoyama Source Type: research
Should you treat prediabetes? It's complicated
J Fam Pract. 2023 Sep;72(7):E23-E25. doi: 10.12788/jfp.0652.ABSTRACTWhile treatment with metformin or lifestyle modification reduces risk for T2D in patients with prediabetes, neither intervention ultimately offers a mortality benefit.PMID:37729142 | DOI:10.12788/jfp.0652
Source: The Journal of Family Practice - September 20, 2023 Category: Practice Management Authors: Daniel Holligan Roxanne Radi Corey Lyon Source Type: research
AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway
In this study, we found that activation of AMPK by AICAR and metformin inhibits foam cell formation via suppression of mTOR in macrophages. Specifically, activation of AMPK indirectly reduced the phosphorylation level of mTOR at Ser2448 and promoted the expression of cholesterol efflux transporters and cholesterol efflux. These inhibitory effects on foam cell formation were counteracted by mTOR activators. Metformin, a more nonspecific AMPK activator than AICAR, appears to inhibit foam cell formation via anti-inflammatory effects in addition to suppression of the mTOR pathway. The results of this study suggest that the dev...
Source: Experimental Cell Research - September 20, 2023 Category: Cytology Authors: Reina Owaki Hiromasa Aoki Kohki Toriuchi Yasumichi Inoue Hidetoshi Hayashi Satoru Takeshita Hiroki Kakita Yasumasa Yamada Mineyoshi Aoyama Source Type: research
Development and validation of the prediction model for mortality in patients with diabetic kidney disease in intensive care unit: a study based on medical information Mart for intensive care
This study establishes a prediction model for predicting mortality of DKD, providing a basis for clinical intervention and decision-making in time.PMID:37724537 | DOI:10.1080/0886022X.2023.2257808
Source: Renal Failure - September 19, 2023 Category: Urology & Nephrology Authors: Wei Jin Haijiao Jin Xinyu Su Miaolin Che Qin Wang Leyi Gu Zhaohui Ni Source Type: research
