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Drug: Methotrexate

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Total 6619 results found since Jan 2013.

< em > HLA-G < /em > 3'UTR polymorphisms & amp; response to a yoga-based lifestyle intervention in rheumatoid arthritis: A randomized controlled trial
CONCLUSIONS: Yoga intervention results in improvement and reduced severity of RA in patients irrespective of the HLA-G 14 bp ins/del or +3142G>C polymorphisms. YBLI may be used as an adjunct therapy in RA independent of the genotypes.PMID:35946202 | DOI:10.4103/ijmr.IJMR_3196_20
Source: The Indian Journal of Medical Research - August 10, 2022 Category: Biomedical Science Authors: Surabhi Gautam Uma Kumar Richa Mishra Rima Dada Source Type: research

The three horizons model applied to medical science
Postgrad Med. 2022 Sep 12. doi: 10.1080/00325481.2022.2124086. Online ahead of print.ABSTRACTThe three horizons model is a framework that helps manage an organization's innovation strategy. This model considers three aspects (horizons) that should be present in the institution and guide the development of new systems. Applied to medical science, the horizons are considered as paradigms that set the guidelines for clinical knowledge. New technologies can influence this model by causing disruptive changes. Horizon 1 (evidence-based medicine) reflects the current paradigm and emphasizes the aspect of continuous improvement ne...
Source: Postgraduate Medicine - September 12, 2022 Category: Internal Medicine Authors: Juan M Roman-Belmonte Hortensia De la Corte-Rodriguez E Carlos Rodriguez-Merchan Aranzazu Vazquez-Sasot Beatriz A Rodriguez-Damiani Cristina Resino-Lu ís Francisco Sanchez-Laguna Source Type: research

Diffuse lung involvement in rheumatoid arthritis: a respiratory physician's perspective
Chin Med J (Engl). 2023 Jan 20. doi: 10.1097/CM9.0000000000002577. Online ahead of print.ABSTRACTThe lungs are one of the most common extra-articular organs involved in rheumatoid arthritis (RA), which is reported to occur in up to 60% to 80% of RA patients. Respiratory complications are the second leading cause of death due to RA. Although there is a wide spectrum of RA-associated respiratory diseases, interstitial lung disease is the most common manifestation and it impacts the prognosis of RA. There has been progress in understanding the management and progression of rheumatoid arthritis-associated interstitial lung dis...
Source: Chinese Medical Journal - January 23, 2023 Category: General Medicine Authors: Hui Huang Ruxuan Chen Chi Shao Zuojun Xu Paul J Wolters Source Type: research

Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis
CONCLUSION: MTX is a promising chemotherapeutic agent for β-catenin hyperactive liver cancer. Since repurposing MTX has the advantages of lower risk, shorter timelines, and less investment in drug discovery and development, a clinical trial is warranted to test its efficacy in the treatment of β-catenin mutant liver cancer.PMID:37612257 | DOI:10.1097/CM9.0000000000002816
Source: Chinese Medical Journal - August 23, 2023 Category: General Medicine Authors: Fangming Liu Yuting Wu Baohui Zhang Shuhui Yang Kezhuo Shang Jie Li Pengju Zhang Weiwei Deng Linlin Chen Liang Zheng Xiaochen Gai Hongbing Zhang Source Type: research

Systemic treatment and medical management of metastatic squamous cell carcinoma of the head and neck: Review of the literature and proposal for management changes
Conclusion: In spite of numerous pending issues requiring further investigation, these recommendations seem to be routinely applicable.
Source: Oral Oncology - February 15, 2013 Category: Cancer & Oncology Authors: Frédéric Peyrade, Didier Cupissol, Lionel Geoffrois, Frédéric Rolland, Christian Borel, Catherine Ciais, Sandrine Faivre, Joël Guigay Tags: Reviews Source Type: research

How to survive the shortage of injectable sodium bicarbonate
Sodium bicarbonate is probably the most versatile antidote in the medical toxicologist’s armamentarium. The list of poisons for which bicarb is indicated lincludes: Sodium-channel blockers (including tricyclic antidepressants) Salicylates phenobarbital methotrexate ethylene glycol methanol chlorine gas inhalation It is, therefore, distressing that bicarb is among the many pharmaceuticals that have recently been in short supply. To read my Emergency Medicine News column on this problem — and find out what to do when sodium bicarbonate is simply not available, click here.
Source: The Poison Review - July 9, 2013 Category: Toxicology Authors: Leon Tags: Medical drug shortage Emergency Medicine News sodium bicarbonate toxicology rounds Source Type: news

RA: Tofacitinib/MTX Improved Pain, Function in Major RCTRA: Tofacitinib/MTX Improved Pain, Function in Major RCT
Adding the JAK inhibitor tofacitinib to methotrexate helped bring active rheumatoid arthritis under control and offered an oral combination alternative to biologicals requiring injection. Medscape Medical News
Source: Medscape Medical News Headlines - August 20, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Current Medical Treatment of Ocular Mucous Membrane Pemphigoid.
Abstract Ocular mucous membrane pemphigoid (MMP), as a potentially blinding disease, is an indication for systemic immunosuppressive treatment. Immunosuppressive agents are chosen with a "stepladder" approach, beginning with drugs having the fewest side effects. Dapsone, sulfapyridine/sulfasalazine and azathioprine are less successful in controlling inflammation than mycophenolate mofetil (MMF) and methotrexate (MTX). Moreover, compared to other immunosuppressive agents, MMF, followed by MTX, has the lowest rate of discontinuation due to side effects. Cyclophosphamide is the most potent immunosuppressive agent use...
Source: The Ocular Surface - October 1, 2013 Category: Opthalmology Authors: Sobolewska B, Deuter C, Zierhut M Tags: Ocul Surf Source Type: research

Children with juvenile idiopathic arthritis frequently experience interruptions to their medical therapy
ConclusionOur study shows a high percentage of interrupted medical therapies, due to adverse events or inefficacy, in children with JIA. Adverse events from methotrexate and biological agents were seldom severe. The results highlight the need for better predictive factors to guide therapy.This article is protected by copyright. All rights reserved.
Source: Acta Paediatrica - January 19, 2014 Category: Pediatrics Authors: Kalliopi Kazamia, Lars Holmquist, Anders Fagerlund, Lillemor Berntson Tags: Regular Article Source Type: research

Medical treatment of ectopic pregnancy
We welcome the recently published article by the Practice Committee of the American Society for Reproductive Medicine on the medical treatment of ectopic pregnancy (EP) . In selected patients methotrexate (MTX) is an effective treatment for unruptured EP and helps to avoid surgical intervention.
Source: Fertility and Sterility - January 13, 2014 Category: Reproduction Medicine Authors: Fernando Infante, Uche Menakaya, George Condous Tags: Letters to the Editor Source Type: research