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Global burden of early-onset colorectal cancer among people aged 40-49 years from 1990 to 2019 and predictions to 2030
CONCLUSION: The current and future burden of EO-CRC among people aged 40-49 years is heavy. Substantial variation exists in disease burden across regions and countries. Urgent screening actions and policies are needed.PMID:37712957 | DOI:10.1007/s00432-023-05395-6
Source: Clinical Colorectal Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Xiaowei Tang Jieyu Peng Shu Huang Huan Xu Ping Wang Jiao Jiang Wei Zhang Xiaomin Shi Lei Shi Xiaolin Zhong Muhan L ü Source Type: research
Assuring the Groundwork for Success: Mentorship, Sponsorship, and Allyship for Practicing Anesthesiologists
Anesth Analg. 2023 Oct 1;137(4):754-762. doi: 10.1213/ANE.0000000000006646. Epub 2023 Sep 5.ABSTRACTThe challenges facing the health care industry in the post-coronavirus disease 2019 (COVID-19) pandemic world are numerous, jeopardizing wellness, and performance. Maintaining engagement and fulfillment of anesthesiologists in their work is now a critical issue in various practice settings: academic, private practice, and corporate medicine. In this article, we offer insights on how mentorship, sponsorship, and allyship are important in the advancement of the anesthesiology workforce including women and underrepresented mino...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Mofya S Diallo Crystal C Wright Alice A Tolbert Coombs Thomas R Vetter Source Type: research
Quality of Life and Needs in Caregivers: Results From the Prospective Multicentric Open-Label Randomized Study of Informal Caregivers of Elderly Patients
Conclusion: These findings call for better recognition of the social support to prevent caregiver QoL deterioration and alleviate their depression early in the course of the disease. Clinical Trial Registration: ClinicalTrials.gov, identifier NCT02626377.PMID:37711159 | PMC:PMC10498993 | DOI:10.3389/ijph.2023.1605459
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Astrid Pozet Sophie Darnis Magalie Bonnet Aur élia Meurisse Tienhan Sandrine Dabakuyo-Yonli Catherine Lejeune Philippe Fagnoni Maryse Gaimard Patrick Manckoundia Cl émence Quibel M élanie Marchand Am élie Anota Virginie Nerich Source Type: research
Effects of a 12 week community-based high-level mobility programme on sustained participation in physical activity by adolescents with cerebral palsy: a single subject research design study
CONCLUSION: Most participants improved physical capacity post-intervention but only some had sustained attendance and involvement in physical activity, highlighting the complexity of physical activity participation.PMID:37712610 | DOI:10.1080/09638288.2023.2256225
Source: Disability and Rehabilitation - September 15, 2023 Category: Rehabilitation Authors: Gaela Kilgour Ngaire Susan Stott Michael Steele Brooke Adair Amy Hogan Christine Imms Source Type: research
Comment on "Telerehabilitation following fast-track total knee arthroplasty is effective and safe: a randomized controlled trial with the ReHub ® platform"
Disabil Rehabil. 2023 Sep 15:1-4. doi: 10.1080/09638288.2023.2259297. Online ahead of print.NO ABSTRACTPMID:37712392 | DOI:10.1080/09638288.2023.2259297
Source: Disability and Rehabilitation - September 15, 2023 Category: Rehabilitation Authors: Thomas Bandholm Source Type: research
Rebalancing polyamine levels to treat Snyder-Robinson syndrome
EMBO Mol Med. 2023 Sep 15:e18506. doi: 10.15252/emmm.202318506. Online ahead of print.ABSTRACTSnyder-Robinson syndrome (SRS) is a rare genetic disorder characterized by intellectual disability and delayed development beginning early in childhood. It was first described in a single family in 1969 as a sex-linked disorder (Snyder & Robinson, 1969) and has since been only identified in less than 100 individuals worldwide. Inherited in an X-linked recessive pattern, SRS has only been identified in males thus far. Snyder-Robinson syndrome primarily affects the nervous system and skeletal tissues and is caused by loss-of-fun...
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Susan K Gilmour Source Type: research
Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway
CONCLUSION: Rhein attenuates cerebral I/R injury by inhibiting ferroptosis via the NRF2/SLC7A11/GPX4 axis, highlighting its potential as a therapeutic agent for ischemic stroke.PMID:37714424 | DOI:10.1016/j.expneurol.2023.114541
Source: Experimental Neurology - September 15, 2023 Category: Neurology Authors: Hua Liu Tian-Ai Zhang Wen-Yue Zhang Si-Rui Huang Yue Hu Jia Sun Source Type: research
Nanotechnology in Coronary Heart Disease
Acta Biomater. 2023 Sep 13:S1742-7061(23)00545-7. doi: 10.1016/j.actbio.2023.09.011. Online ahead of print.ABSTRACTCoronary heart disease (CHD) is one of the major causes of death and disability worldwide, especially in low- and middle-income countries and among older populations. Conventional diagnostic and therapeutic approaches have limitations such as low sensitivity, high cost and side effects. Nanotechnology offers promising alternative strategies for the diagnosis and treatment of CHD by exploiting the unique properties of nanomaterials. In this review, we use bibliometric analysis to identify research hotspots in t...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Junsong Guo Hao Wang Ying Li Shuang Zhu Houxiang Hu Zhanjun Gu Source Type: research
Glutaric Acidemia Type 1: Diagnosis, Clinical features, and Outcome in a Portuguese Cohort
CONCLUSION: The outcomes were different between the two groups: all the LD patients presented motor dysfunction however in the NBS-identified patients only 5 developed this symptom. Patients identified by NBS had better outcomes showing that NBS enables an early diagnosis, and treatment, and consequently improves the clinical outcomes for these patients. No correlation was observed with clinical phenotype between LE and HE, as both groups can suffer the most severe neurological manifestations. These conclusions are in agreement with previous cohorts described in the literature.PMID:37711119 | DOI:10.2174/1871530323666230914122946
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Patr ícia Lipari Pinto Beatriz C âmara Cristina Florindo Rita Santos Loureiro In ês Jardim Carmen Sousa Laura Vilarinho Patr ícia Janeiro Isabel Tavares de Almeida Ana Gaspar Source Type: research
Managing osteoporosis in COPD
Endocr Metab Immune Disord Drug Targets. 2023 Sep 13. doi: 10.2174/1871530323666230913105752. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a serious respiratory disease with high morbidity, disability and mortality worldwide. Every year, many people die from the disease or its comorbidities. Osteoporosis is a common complication of COPD, which can lead to increased fractures in COPD patients, aggravate the disease, and then bring great pain and burden to patients. The possible factors leading to osteoporosis in COPD patients include systemic inflammation, corticosteroid use, vitamin D defic...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Lilan Shen Juanqin Lv Jie Li Jing Zhou Xiaomin Wang Source Type: research
SERAC1 Deficiency- A New Phenotype
Conclusion - The first patient has the clinical symptoms associated to the MEGD(H)EL syndrome, and the biochemical and genetic confirmation of the diagnosis, without reservations. However, in the second patient, the progressive paraparesis and cognitive impairment did not appear to be caused by multiple sclerosis nor subcortical vascular leukoencephalopathy (without vascular risk factors). The abnormal biochemical profile is suggestive of SERAC1 Deficiency, even without genetic confirmation. In what should we believe?PMID:37711114 | DOI:10.2174/1871530323666230914114456
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Emanuel Martins Jo ão Durães C élia Nogueira Jo ão Gomes Laura Vilarinho Carmo Mac ário Source Type: research
Glutaric Acidemia Type 1: Diagnosis, Clinical features, and Outcome in a Portuguese Cohort
CONCLUSION: The outcomes were different between the two groups: all the LD patients presented motor dysfunction however in the NBS-identified patients only 5 developed this symptom. Patients identified by NBS had better outcomes showing that NBS enables an early diagnosis, and treatment, and consequently improves the clinical outcomes for these patients. No correlation was observed with clinical phenotype between LE and HE, as both groups can suffer the most severe neurological manifestations. These conclusions are in agreement with previous cohorts described in the literature.PMID:37711119 | DOI:10.2174/1871530323666230914122946
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Patr ícia Lipari Pinto Beatriz C âmara Cristina Florindo Rita Santos Loureiro In ês Jardim Carmen Sousa Laura Vilarinho Patr ícia Janeiro Isabel Tavares de Almeida Ana Gaspar Source Type: research
Managing osteoporosis in COPD
Endocr Metab Immune Disord Drug Targets. 2023 Sep 13. doi: 10.2174/1871530323666230913105752. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a serious respiratory disease with high morbidity, disability and mortality worldwide. Every year, many people die from the disease or its comorbidities. Osteoporosis is a common complication of COPD, which can lead to increased fractures in COPD patients, aggravate the disease, and then bring great pain and burden to patients. The possible factors leading to osteoporosis in COPD patients include systemic inflammation, corticosteroid use, vitamin D defic...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Lilan Shen Juanqin Lv Jie Li Jing Zhou Xiaomin Wang Source Type: research
SERAC1 Deficiency- A New Phenotype
Conclusion - The first patient has the clinical symptoms associated to the MEGD(H)EL syndrome, and the biochemical and genetic confirmation of the diagnosis, without reservations. However, in the second patient, the progressive paraparesis and cognitive impairment did not appear to be caused by multiple sclerosis nor subcortical vascular leukoencephalopathy (without vascular risk factors). The abnormal biochemical profile is suggestive of SERAC1 Deficiency, even without genetic confirmation. In what should we believe?PMID:37711114 | DOI:10.2174/1871530323666230914114456
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Emanuel Martins Jo ão Durães C élia Nogueira Jo ão Gomes Laura Vilarinho Carmo Mac ário Source Type: research
Adverse childhood experiences: a meta-analysis of prevalence and moderators among half a million adults in 206 studies
World Psychiatry. 2023 Oct;22(3):463-471. doi: 10.1002/wps.21122.ABSTRACTExposure to adverse childhood experiences (ACEs), including maltreatment and family dysfunction, is a major contributor to the global burden of disease and disability. With a large body of international literature on ACEs having emerged over the past 25 years, it is timely to now synthetize the available evidence to estimate the global prevalence of ACEs and, through a series of moderator analyses, determine which populations are at higher risk. We searched studies published between January 1, 1998 and August 5, 2021 in Medline, PsycINFO and Embase. S...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Sheri Madigan Audrey-Ann Deneault Nicole Racine Julianna Park Raela Thiemann Jenney Zhu Gina Dimitropoulos Tyler Williamson Pasco Fearon Jude Mary C énat Sheila McDonald Chloe Devereux Ross D Neville Source Type: research
