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Positive New Data for Johnson & Johnson Single-Shot COVID-19 Vaccine on Activity Against Delta Variant and Long-lasting Durability of Response
NEW BRUNSWICK, N.J., July 1, 2021 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced data that demonstrated its single-shot COVID-19 vaccine generated strong, persistent activity against the rapidly spreading Delta variant and other highly prevalent SARS-CoV-2 viral variants. In addition, the data showed that the durability of the immune response lasted through at least eight months, the length of time evaluated to date. The two preprint study summaries have been submitted today to bioRxiv. “Today’s newly announced studies reinforce the ability of the Johnson & Johnson COVID-19 vaccine to help prot...
Source: Johnson and Johnson - July 1, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Johnson & Johnson Single-Shot COVID-19 Vaccine Phase 3 Data Published in New England Journal of Medicine
NEW BRUNSWICK, N.J., April 21, 2021 – Johnson & Johnson (the Company) today announced publication in the New England Journal of Medicine of primary data from the Phase 3 ENSEMBLE clinical trial for its single-dose COVID-19 vaccine, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen). The publication of the primary analysis follows the topline efficacy and safety data announced in January, showing the trial met all primary and key secondary endpoints, and found that the Johnson & Johnson single-dose COVID-19 vaccine prevented hospitalization and death across all study participants ...
Source: Johnson and Johnson - April 21, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Johnson & Johnson Expands Phase 2a Clinical Trial of COVID-19 Vaccine Candidate to Include Adolescents
New Brunswick, NJ (April 2, 2021) – Johnson & Johnson (the Company) has begun vaccinating adolescent participants in the ongoing Phase 2a clinical trial for its COVID-19 vaccine candidate, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson. “The COVID-19 pandemic has had a profound impact on adolescents, not just with the complications of the disease, but with their education, mental health, and wellbeing,” said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer at Johnson & Johnson. “It is vital that we develop vaccines for everyone, everywher...
Source: Johnson and Johnson - April 2, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Risk of Zika virus transmission from mother to unborn child much higher than expected
FINDINGSAccording to a new study by UCLA researchers and colleagues conducted in Brazil, 65% of children born to mothers infected withthe Zikavirusalsotested positive for the mosquito-borneinfection— a much higher rate than expected.The findings indicatethat even babies whohave no outward neurological or other symptoms associated with Zika can still be infected with the virus andare potentially at risk offuturedevelopmental problems.  BACKGROUNDThe study representsthe first time that the mother-to-child transmission rate of Zika has been reportedfor a group of children who were tracked over several years — including f...
Source: UCLA Newsroom: Health Sciences - July 27, 2020 Category: Universities & Medical Training Source Type: news

A third of children up to age 3 exposed to Zika in-utero have neurological problems
New UCLA-led research suggests that 32% of children up to the age of 3 years who were exposed to the Zika virus during the mother ’s pregnancy had below-average neurological development.The study also found that fewer than 4% of 216 children evaluated had microcephaly —a smaller-than-normal head that is one of the hallmarks of the mosquito-borne disease. The heads of two of those children grew to normal size over time, the researchers reported.The studywas published in the journal Nature Medicine.The findings, conducted by UCLA researchers with colleagues in Rio de Janeiro, Brazil, where the disease was first detected,...
Source: UCLA Newsroom: Health Sciences - July 8, 2019 Category: Universities & Medical Training Source Type: news

The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

HIV-positive infants are at high risk for acquiring congenital cytomegalovirus infection
FINDINGSInfants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection.The researchers found that 23 percent of the infants who became infected with HIV during the mother ’s pregnancy also were infected with CMV; 18 percent who were infected with HIV either during pregnancy or birth acquired congenital CMV; and 4.9 percent who were exposed to HIV but remained uninfected with that virus also acquired congenital CMV.Overall, HIV-infected infants were four times as likely to have acqui...
Source: UCLA Newsroom: Health Sciences - October 15, 2018 Category: Universities & Medical Training Source Type: news

Oral Desensitization to Penicillin for the Treatment of Pregnant Women with Syphilis: A Successful Program
We report a successful program of oral desensitization. None of the patients presented adverse reactions or complications, a fact that corroborates the feasibility and safety of the desensitization protocol. Oral administration of penicillin comes at a low cost, and optimizes the use of time and resources.Resumo A s ífilis gestacional é uma doença prevalente no Brasil e em outros países de baixa e média renda. A dessensibilização à penicilina é recomendada para mulheres grávidas com sífilis que são alérgicas a β -lact âmicos. Este é um estudo descritivo que utiliza registros médicos de 2011 a 2015 de um ho...
Source: Revista Brasileira de Ginecologia e Obstetricia - May 29, 2018 Category: OBGYN Source Type: research

Lab-confirmed prenatal exposure to Zika is linked to cardiac defects in infants
In this study, researchers performed echocardiograms in infants with laboratory confirmation of in utero exposure to Zika to investigate a potential link between prenatal Zika exposure and congenital heart defects.METHODThe researchers performed cardiac echocardiograms in infants born in Rio de Janeiro, Brazil, from November 2015 to January 2017. All infants were infected with the Zika virus during their mothers ’ pregnancy, as confirmed by laboratory tests.IMPACTWomen infected by Zika during pregnancy were 10 times more likely than the general population to give birth to infants with major cardiac defects. The researche...
Source: UCLA Newsroom: Health Sciences - May 16, 2018 Category: Universities & Medical Training Source Type: news

Decomposition Analysis of Black –White Disparities in Birth Outcomes: The Relative Contribution of Air Pollution and Social Factors in California
Conclusions: Our results suggest that, although the role of individual and neighborhood factors remains prevailing in explaining black–white differences in birth outcomes, the individual contribution of PM2.5 is comparable in magnitude to any single individual- or neighborhood-level factor. https://doi.org/10.1289/EHP490 Received: 10 May 2016 Revised: 16 December 2016 Accepted: 03 January 2017 Published: 04 October 2017 Address correspondence to T. Benmarhnia, Department of Family Medicine and Public Health, and Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, La Jolla, C...
Source: EHP Research - October 4, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Coagulation Factor XII Gene Mutation in Brazilian Families with Hereditary Angioedema with Normal C1 Inhibitor
Conclusions: We report for the first time in Brazil a mutation in the F12 gene as a likely cause of HAE with normal C1-INH in patients with recurrent attacks of angioedema and/or abdominal pain. A higher frequency of abdominal pain attacks and onset of symptoms at a younger age were observed among Brazilian patients when compared to those from other parts of the world.Int Arch Allergy Immunol 2015;166:114-120
Source: International Archives of Allergy and Immunology - March 12, 2015 Category: Allergy & Immunology Source Type: research