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Predictors of Good Clinical Outcome in Acute Stroke Patients Underwent Recanalization Therapy (P01.242)
CONCLUSIONS: NIHSS at admission, recanalization grade and early neurological improvement are independent predictors of clinical outcome in AIS patients underwent mechanical recanalization.Supported by: IGA MH CR grants NT/11386-5/2010, NT/11046-6/2010, NT/13498-4/2012.Disclosure: Dr. Skoloudik has nothing to disclose. Dr. Roubec has nothing to disclose. Dr. Kuliha has nothing to disclose. Dr. Herzig has received personal compensation for activities with Bayer, Boehringer Ingelheim Pharmaceuticals, Inc., and Gedeon Richter. Dr. Sanak has received personal compensation from Boehringer Ingelheim for serving on a scientific ad...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Skoloudik, D., Roubec, M., Kuliha, M., Herzig, R., Sanak, D., Prochazka, V., Hrbac, T. Tags: P01 Cerebrovascular Disease I Source Type: research

Lesion location, stability, and pretreatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis
Conclusions Endovascular treatment of symptomatic vertebrobasilar atherosclerosis can be performed safely and with good outcomes. Technical results were better for those with extracranial disease while clinical outcomes were more favorable in those patients with non-progressive symptoms in the subacute period and those receiving statin therapy.
Source: Journal of NeuroInterventional Surgery - April 13, 2016 Category: Neurosurgery Authors: Alexander, M. D., Rebhun, J. M., Hetts, S. W., Kim, A. S., Nelson, J., Kim, H., Amans, M. R., Settecase, F., Dowd, C. F., Halbach, V. V., Higashida, R. T., Cooke, D. L. Tags: Ischemic stroke Source Type: research

The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.
Abstract Statins, 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors, have been used for decades for the prevention of coronary artery disease and stroke. They act primarily by lowering serum cholesterol through the inhibition of cholesterol synthesis in the liver, which results in the upregulation of low-density lipoprotein receptors in the liver. This results in the removal of low-density lipoprotein-cholesterol. Studies have suggested that statins may demonstrate additional effects that are independent of their effects on low-density lipoprotein-cholesterol. These have been termed "pleiotropic" effects. P...
Source: Current Vascular Pharmacology - August 17, 2018 Category: Drugs & Pharmacology Authors: Liao JK, Oesterle A Tags: Curr Vasc Pharmacol Source Type: research

Statins Use and Outcome of Acute Ischemic Stroke Patients after Systemic Thrombolysis
Conclusion: Our study does not show any significant association between risk of sICH and poor outcome after IVT for patients on prior statin therapy. We also did not find significant association between the risk of sICH and poor outcome after IVT and the intensity of the stain used.Cerebrovasc Dis
Source: Cerebrovascular Diseases - September 14, 2020 Category: Neurology Source Type: research

Number of Cerebral Microbleeds and Risk of Intracerebral Hemorrhage After Intravenous Thrombolysis Clinical Sciences
Conclusions— Our findings indicate a higher risk of sICH and PH after intravenous thrombolysis when multiple CMBs are present, with a graded relationship to increasing baseline CMB number.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Dannenberg, S., Scheitz, J. F., Rozanski, M., Erdur, H., Brunecker, P., Werring, D. J., Fiebach, J. B., Nolte, C. H. Tags: Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis Clinical Sciences Source Type: research

Clinical Reasoning: A 66-year-old man with recurrent multi-territory infarcts
A 66-year-old man was referred to our center for evaluation of recurrent infarcts in multiple vascular territories over the preceding 6 months (figure 1). The patient first presented with a 3-month, stuttering course of transient neurologic deficits, including right arm and leg hemiparesis, expressive aphasia, and right homonymous hemianopia. He was initially evaluated at a community Stroke Prevention Clinic. His medical history was significant for several classic vascular risk factors: coronary artery disease requiring a coronary artery bypass graft, dyslipidemia for which he was taking atorvastatin 20 mg daily, and obstr...
Source: Neurology - June 8, 2015 Category: Neurology Authors: Kouzmitcheva, E., Steriade, C., Prica, A., Hazrati, L.-N., Mandell, D. M. Tags: All Cerebrovascular disease/Stroke, All Education RESIDENT AND FELLOW SECTION Source Type: research

A Study on the Occurrence and Prevention of Perioperative Stroke after Coronary Artery Bypass Grafting.
This article is a secondary publication of J Jpn Coron Assoc 2014; 20: 91-7.). PMID: 26050596 [PubMed - as supplied by publisher]
Source: Annals of Thoracic and Cardiovascular Surgery - June 5, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Sezai A, Nakata KI, Iida M, Yoshitake I, Wakui S, Osaka S, Kimura H, Takahashi K, Ishi Y, Yaoita H, Arimoto M, Hata H, Shiono M, Takayama T, Hirayama A Tags: Ann Thorac Cardiovasc Surg Source Type: research

Prevention of Stroke in Rheumatoid Arthritis
Abstract The risk of cerebrovascular disease is increased among rheumatoid arthritis (RA) patients and remains an underserved area of medical need. Only a minor proportion of RA patients achieve suitable stroke prevention. Classical cardiovascular risk factors appear to be under-diagnosed and undertreated among patients with RA. Reducing the inflammatory burden is also necessary to lower the cardiovascular risk. An adequate control of disease activity and cerebrovascular risk assessment using national guidelines should be recommended for all patients with RA. For patients with a documented history of cerebrovascu...
Source: Current Neurology and Neuroscience Reports - October 20, 2015 Category: Neuroscience Source Type: research

Response to "Association between statin use and ischemic stroke or major hemorrhage in patients taking dabigatran for atrial fibrillation".
PMID: 28246232 [PubMed - in process]
Source: cmaj - February 26, 2017 Category: Journals (General) Authors: Antoniou T, Mamdani M, Juurlink D Tags: CMAJ Source Type: research

Association between statin use and ischemic stroke or major hemorrhage in patients taking dabigatran for atrial fibrillation.
PMID: 28246231 [PubMed - in process]
Source: cmaj - February 26, 2017 Category: Journals (General) Authors: Haertter S, Huang F, Franca LR Tags: CMAJ Source Type: research

Statin Use Cuts Five-Year Stroke Risk for Patients With Atrial Fibrillation
MONDAY, May 15, 2023 -- Statin use is associated with a lower risk for incident stroke and transient ischemic attack (TIA) in a duration-dependent manner among patients with atrial fibrillation (AF), according to a study presented at the annual...
Source: Drugs.com - Pharma News - May 15, 2023 Category: Pharmaceuticals Source Type: news

Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis
Conclusion: We found a statistically insignificant tendency for the ultrasound-measured length of sICAS<70% to be longer than that of sICAS≥70%. Moreover, the ultrasound-measured length of sICAS<90% was significantly longer than that of sICAS 90%. Among patients with sICAS≥70%, the degree and length of stenosis were inversely correlated. Larger studies are needed before a clinical implication can be drawn from these results. Introduction Internal carotid artery stenosis (ICAS) causes around one-fifth of ischemic cerebrovascular stroke and has the highest risk of early stroke recurrence...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions
RARITAN, N.J., April 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from new analyses from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefit of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in reducing severe vascular events in patients with PAD after lower-extremity revascularization (LER), a procedure that restores blood flow to the legs. Data from the two analyses demonstrate the role that the XARELTO® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and ...
Source: Johnson and Johnson - April 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

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