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Condition: Atrial Fibrillation
Countries: Japan Health

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Total 333 results found since Jan 2013.

Major cardiovascular and bleeding events with long-term use of aspirin in patients with prior cardiovascular diseases: 1-year follow-up results from the Management of Aspirin-induced Gastrointestinal Complications (MAGIC) study
This study was conducted to clarify CV and bleeding events in Japanese aspirin users with a history of CV diseases. This study was a prospective, nationwide, multicenter cooperative registry of Japanese patients with CV diseases at risk of thromboembolism who were taking aspirin (75–325 mg) for at least 1 year. We observed major CV and bleeding events during follow-up. Patients with history of ischemic stroke (IS), transient ischemic attack (TIA), coronary artery disease (CAD), atrial fibrillation (AF), and venous thromboembolism (VTE) were included and analyzed in this sutdy. CV events included IS, TIA, CAD, CV death,...
Source: Heart and Vessels - August 23, 2019 Category: Cardiology Source Type: research

Bioequivalence of a Newly Developed Dabigatran Etexilate Tablet Versus the Commercial Capsule and Impact of Rabeprazole-Induced Elevated Gastric pH on Exposure in Healthy Subjects
ConclusionThe DE tablet demonstrated BE to the capsule; however, at high gastric pH, BA of the tablet was reduced by approximately 70%, which may lead to reduced efficacy. Data indicate the importance of examining not only BE under standard conditions, but relative BA at elevated gastric pH. Such investigations may avoid the reduced BA at elevated pH that is quite common in the target population (the elderly and/or patients treated with gastric-acid modifying co-medications), and therefore reduce treatment failure with DE.Registration: ClinicalTrials.gov identifier numbers: NCT03070171, and NCT03143166
Source: American Journal of Cardiovascular Drugs - October 29, 2019 Category: Cardiology Source Type: research

Comparison of continuous 24-h and 14-day monitoring for detection of otherwise unknown atrial fibrillation: a registry to identify Japanese concealed atrial fibrillation (REAL-AF)-based study
AbstractEarly detection of atrial fibrillation (AF) is desirable for preventing strokes. Not only does AF often go undetected in patients being followed up for various disease conditions, but the optimal detection method also remains to be elucidated. In a prospective observational study of 24-h Holter monitoring versus 14-day external loop recording performed for detection of previously undiagnosed AF in 868 Japanese outpatients (aged 75  ± 6 years), with a CHA2DS2-vasc score ≥ 1, but no prior AF episodes, AF was detected during the initial monitoring period in 16 (1.8%) patients, in 7 (1.1% [7/645]) by 24-h m...
Source: Heart and Vessels - November 5, 2019 Category: Cardiology Source Type: research

Low Consultation Rate of General Population with Atrial Fibrillation.
In conclusion, about one-third of the patients with AF did not regularly see a doctor in a medical institution and most of them had a CHADS2 score of more than one point in a Japanese rural area. Educating the public about the risks of AF is required. PMID: 31735770 [PubMed - as supplied by publisher]
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Age-Related Differences in the Clinical Characteristics and Treatment of Elderly Patients With Atrial Fibrillation in Japan 　- Insight From the ANAFIE (All Nippon AF In Elderly) Registry.
CONCLUSIONS: Permanent/persistent AF, comorbidities, and cardiovascular and bleeding risk all increased significantly with age. Furthermore, use of warfarin and apixaban increased with age, accompanied by a decrease in other oral anticoagulant usage. PMID: 31969518 [PubMed - as supplied by publisher]
Source: Circulation Journal - January 22, 2020 Category: Cardiology Authors: Hiasa KI, Kaku H, Inoue H, Yamashita T, Akao M, Atarashi H, Koretsune Y, Okumura K, Shimizu W, Ikeda T, Toyoda K, Hirayama A, Yasaka M, Yamaguchi T, Teramukai S, Kimura T, Kaburagi J, Takita A, Tsutsui H Tags: Circ J Source Type: research

Rhythm versus rate control strategies regarding anticoagulant use in elderly non-valvular atrial fibrillation patients: Subanalysis of the ANAFIE (All Nippon AF In the Elderly) Registry.
CONCLUSIONS: Use versus non-use and antiarrhythmic therapy varied significantly by age, stroke risk scores, type of AF, and DOAC use between subgroups. PMID: 32081607 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - February 17, 2020 Category: Cardiology Authors: Yuzawa H, Inoue H, Yamashita T, Akao M, Atarashi H, Koretsune Y, Okumura K, Shimizu W, Tsutsui H, Toyoda K, Hirayama A, Yasaka M, Yamaguchi T, Teramukai S, Kimura T, Kaburagi J, Takita A, Ikeda T Tags: J Cardiol Source Type: research

Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010.
CONCLUSIONS: In the contemporary general population cohort, PTFV1 was independently related to high BNP concentration. PTFV1 may be an alternative marker to BNP in identifying individuals at a higher risk of future cardiovascular events in the East Asian population. PMID: 32188793 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - March 21, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Impact of Valvular Heart Disease on Mortality, Thromboembolic and Cardiac Events in Japanese Patients With Atrial Fibrillation 　- The Fushimi AF Registry.
CONCLUSIONS: Although VHD did not significantly affect thromboembolism or mortality, it affected cardiac events depending on type, with aortic valve diseases having higher risk, in Japanese patients with AF. PMID: 32213725 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 24, 2020 Category: Cardiology Authors: Doi K, Ogawa H, Ishigami K, Ikeda S, Aono Y, Hamatani Y, Fujino A, An Y, Ishii M, Iguchi M, Masunaga N, Esato M, Tsuji H, Wada H, Hasegawa K, Abe M, Akao M, Fushimi AF Registry Investigators Tags: Circ J Source Type: research

Ethnic differences in atrial fibrillation among patients with heart failure in Asia
ConclusionsAmong patients with HF across Asia, clinical correlates and adverse outcomes associated with AF are similar across ethnicities; however, there are striking ethnic variations in the prevalence of AF that are not accounted for by known risk factors.
Source: ESC Heart Failure - May 7, 2020 Category: Cardiology Authors: Eugene S.J. Tan, Vera Goh, Bernadet T. Santema, Wan Ting Tay, Tiew ‐Hwa Katherine Teng, Jonathan Yap, Jasper Tromp, Chung‐Lieh Hung, Vijay Chopra, Inder Anand, Michael R. MacDonald, Lieng Hsi Ling, ASIAN‐HF investigators, Isabelle C. Va Tags: Original Research Article Source Type: research

Clinical implications of assessment of apixaban levels in elderly atrial fibrillation patients: J-ELD AF registry sub-cohort analysis
ConclusionsA high trough apixaban level in patients indicated for standard dose was not associated with adverse events, while a high apixaban level in patients indicated for a reduced dose was associated with bleeding requiring hospitalization.
Source: European Journal of Clinical Pharmacology - May 24, 2020 Category: Drugs & Pharmacology Source Type: research

Meta-analysis of efficacy and safety of new oral anticoagulants compared with warfarin in Japanese patients undergoing catheter ablation for atrial fibrillation
ConclusionsIn Japanese NVAF patients undergoing CA, NOACs have similar effects to warfarin in the prevention of stroke and systemic embolism. Moreover, NOACs were associated with a lower incidence of bleeding complications.
Source: Journal of Interventional Cardiac Electrophysiology - May 26, 2020 Category: Cardiology Source Type: research

Anti-Factor Xa Activity of Standard and Japan-Specific Doses of Rivaroxaban in Thai Patients With Non-Valvular Atrial Fibrillation.
CONCLUSIONS: A significantly higher proportion of Thai patients receiving the Japan-specific dose of rivaroxaban had anti-FXa activity at peak concentrations within the expected range. PMID: 32461505 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 25, 2020 Category: Cardiology Authors: Wongcharoen W, Pacharasupa P, Norasetthada L, Gunaparn S, Phrommintikul A Tags: Circ J Source Type: research

Analysis of bioMARKer Distribution and Individual Reproducibility Under Rivaroxaban Treatment in Japanese Patients with Non-Valvular Atrial Fibrillation (R-MARK Study, CVI ARO2).
We reported the on-therapy range of rivaroxaban in a multicenter cohort. This range was consistent with that of a single-center cohort and was highly reproducible within three months in daily clinical practice. However, caution is necessary regarding several factors that may affect the intraindividual variation of PC-Riv. PMID: 32684604 [PubMed - as supplied by publisher]
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Rationale, Design, and Baseline Characteristics of the BioProsthetic Valves with Atrial Fibrillation (BPV-AF) Study
ConclusionPatients enrolled into this study are typical of the wider Japanese AF/BPV population in terms of age and clinical history. Future data accruing from the observational period will contribute to future treatment recommendations and guide therapeutic decisions in patients with BPV and AF.Trial registrationClinicalTrials.gov Identifier: UMIN000034485
Source: Cardiovascular Drugs and Therapy - July 23, 2020 Category: Cardiology Source Type: research

Device use for proximal anastomosis on ascending aorta in off-pump coronary artery bypass grafting.
CONCLUSIONS: Clinical safety of Device use in CABG comparable to No-touch for mortality and morbidity. Hemostasis may be a key issue for accomplishing higher level quality control when devices used in proximal anastomosis of CABG. PMID: 33065052 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - October 13, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Saito A, Kumamaru H, Miyata H, Motomura N Tags: Ann Thorac Surg Source Type: research