Filtered By:
Specialty: Neuroscience
Condition: Thrombosis

This page shows you your search results in order of relevance. This is page number 5.

Order by Relevance | Date

Total 164 results found since Jan 2013.

International benchmarking for acute thrombolytic therapy implementation in Australia and Japan
Publication date: July 2016 Source:Journal of Clinical Neuroscience, Volume 29 Author(s): Hiroyuki Kawano, Christopher Levi, Yuichiro Inatomi, Heather Pagram, Erin Kerr, Andrew Bivard, Neil Spratt, Ferdinand Miteff, Toshiro Yonehara, Yukio Ando, Mark Parsons Although a wide range of strategies have been established to improve intravenous tissue plasminogen activator (IV-tPA) treatment rates, international benchmarking has not been regularly used as a systems improvement tool. We compared acute stroke codes (ASC) between two hospitals in Australia and Japan to study the activation process and potentially improv...
Source: Journal of Clinical Neuroscience - May 29, 2016 Category: Neuroscience Source Type: research

Pharmacologic cardioversion with intravenous amiodarone is likely safe in neurocritically Ill patients
Publication date: Available online 13 February 2017 Source:Journal of Clinical Neuroscience Author(s): Michael Su, David Seki, Asma M. Moheet Neurological injury is often associated with cardiac abnormalities, including electrophysiological issues. Cardioversion of acute atrial fibrillation (<48h’ duration) without anticoagulation carries about a 0.7% risk of thromboembolism. There is limited data on managing acute atrial fibrillation specifically in the neuroscience intensive care unit (NSICU) setting. We sought to determine the safety of using intravenous (IV) amiodarone for restoring sinus rhythm in patients w...
Source: Journal of Clinical Neuroscience - February 13, 2017 Category: Neuroscience Source Type: research

Prothymosin alpha and its mimetic hexapeptide improve delayed tissue plasminogen activator ‐induced brain damage following cerebral ischemia
Administration of tissue plasminogen activator (tPA) beyond 4.5 h increases the risk of cerebral hemorrhage. Here, tPA administration during reperfusion at 4.5 or 6  h after middle cerebral artery occlusion or photochemically induced thrombosis in mice caused brain damage with hemorrhage. Co‐administration of prothymosin α (ProTα) or its mimetic hexapeptide (P6Q) inhibited tPA‐induced such brain damage. Therefore, ProTα or P6Q co‐administration would be beneficial to inhibit tPA‐induced hemorrhagic mechanisms in ischemic stroke. AbstractTissue plasminogen activator (tPA) administration beyond 4.5  h of stroke ...
Source: Journal of Neurochemistry - October 9, 2019 Category: Neuroscience Authors: Sebok Kumar Halder, Hayato Matsunaga, Hiroshi Ueda Tags: Original Article Source Type: research

Cerebrovascular Complications of Anemia
AbstractPurpose of the ReviewAnemia has been called the fifth cardiovascular risk factor. It is one of the most prevalent pathologies worldwide. In this article, we aimed to perform a narrative review of the main cerebrovascular complications of anemia and its influence on stroke prognosis.Recent FindingsBoth hypoproliferative anemia (thalassemia, iron deficiency anemia, etc.) and hyperproliferative anemia (sickle cell disease, paroxysmal nocturnal hemoglobinuria, hereditary spherocytosis, etc.) are associated to cerebrovascular disease ranging from transient ischemic attack to ischemic stroke and hemorrhagic stroke with b...
Source: Current Neurology and Neuroscience Reports - September 3, 2021 Category: Neuroscience Source Type: research

Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers
CONCLUSION: A systematic understanding of particular risk factors that should not be neglected when unconventional cerebral venous thrombosis occurs and for a scientific understanding of pathophysiological mechanisms, clinical diagnosis, and treatment, thus contributing to knowledge on special types of venous stroke.PMID:37365966 | DOI:10.1111/cns.14321
Source: CNS Neuroscience and Therapeutics - June 27, 2023 Category: Neuroscience Authors: Yifan Zhou Huimin Jiang Huimin Wei Xuechun Xiao Lu Liu Xunming Ji Chen Zhou Source Type: research

A study of ER stress in rat model of cerebral venous sinus thrombosis
Publication date: 4 March 2015 Source:Neuroscience Letters, Volume 589 Author(s): Hari Shanker Tiwari , Amit Kumar Tripathi , Durga Prasad Mishra , Jayantee Kalita , Usha Kant Misra Cerebral venous sinus thrombosis (CVST) is a rare form of stroke. The role of endoplasmic reticulum (ER) stress markers is well documented in arterial stroke but has not been evaluated in venous stroke. The present study has been undertaken to investigate the role of ER stress in rodent model of CVST. For inducing CVST, a cranial window was made to expose superior sagittal sinus (SSS). A strip of filter paper soaked with 40% ferric chloride w...
Source: Neuroscience Letters - January 25, 2015 Category: Neuroscience Source Type: research

A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research

Dl-3-N-Butylphthalide Alleviates the Blood–Brain Barrier Permeability of Focal Cerebral Ischemia Reperfusion in Mice
In conclusion, NBP exerts neuroprotective effects through attenuating cerebral infarct volume and neurological deficit score, reducing cerebral edema and BBB permeability. The neuroprotective effect of NBP is possibly related to its ability to improve blood flow in cerebral ischemic areas. NBP may turn into a novel treatment drug to prevent BBB dysfunction in ischemic stroke.
Source: Neuroscience - June 26, 2019 Category: Neuroscience Source Type: research

Prothymosin alpha and its mimetic hexapeptide improve delayed tPA ‐induced brain damage following cerebral ischemia
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - August 26, 2019 Category: Neuroscience Authors: Sebok Kumar Halder, Hayato Matsunaga, Hiroshi Ueda Tags: Original Article Source Type: research

Basilar artery thrombosis during sexual intercourse
We report a young woman with a life-threatening basilar artery thrombosis during sexual intercourse, with a resulting locked-in syndrome. The positive high intensity transient signals (HITS) diagnosis showed a right-to-left shunt and is in line with paradoxic embolism. The molecular genetics revealed a homozygosity 4G/4G in the region PAI1, -675 (promoter polymorphism) as a risk factor for ischemic stroke. Sexual intercourse is a possible, albeit unusual stroke cause, especially in young people.
Source: Journal of Clinical Neuroscience - January 23, 2020 Category: Neuroscience Source Type: research

Assessment of recombinant tissue plasminogen activator (rtPA) toxicity in cultured neural cells and subsequent treatment with poly-arginine peptide R18D.
Abstract Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) in ischaemic stroke has been associated with neurotoxicity, blood brain barrier (BBB) disruption and intra-cerebral hemorrhage. To examine rtPA cellular toxicity we investigated the effects of rtPA on cell viability in neuronal, astrocyte and brain endothelial cell (bEnd.3) cultures with and without prior exposure to oxygen-glucose deprivation (OGD). In addition, the neuroprotective peptide poly-arginine-18 (R18D; 18-mer of D-arginine) was examined for its ability to reduce rtPA toxicity. Studies demonstrated that a 4- or 24-h expos...
Source: Neurochemical Research - March 4, 2020 Category: Neuroscience Authors: Kenna JE, Anderton RS, Knuckey NW, Meloni BP Tags: Neurochem Res Source Type: research

IMM‐H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA‐and PI3K‐dependent Akt activation
Abstract Ischemic stroke is currently treated with thrombolytic therapy with a drawback to induce hemorrhagic transformation (HT) if applied beyond its relatively narrow treatment time window. The present study was designed to examine the role of IMM‐H004, a derivative of coumarin, in recombinant tissue plasminogen activator (tPA)‐induced HT. Rats subjected to 6 h of thromboembolic occlusion or middle cerebral artery occlusion received tPA with or without IMM‐H004. Delayed tPA intervention drastically increased the risk of HT and exaggerated the ischemic injury. To assess the effect of IMM‐H004 on delayed treatmen...
Source: European Journal of Neuroscience - March 20, 2014 Category: Neuroscience Authors: Wei Zuo, Jiao Chen, Shuai Zhang, Jia Tang, Hang Liu, Dongming Zhang, Naihong Chen Tags: Research Report Source Type: research

Calcific emboli originating from the brachiocephalic trunk causing acute cerebral infarction and worm-like calcification in the right middle cerebral artery
We report, to our knowledge, the first patient with brachiocephalic trunk calcified plaque causing the ‘salted pretzel sign’ and worm-like calcification. Arterial stenosis or occlusion caused by atherosclerosis and thrombosis are responsible for the majority of cases of cerebral infarction. However, there are a number of other causes. Interestingly, these findings were not observed on a CT scan 10days before the stroke. Acute cerebral infarction with calcifications on unenhanced head CT scans should raise suspicion for disease in the carotid system. Identification of subtle findings of acute ischemic stroke on CT scans...
Source: Journal of Clinical Neuroscience - April 28, 2015 Category: Neuroscience Source Type: research