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Specialty: General Medicine
Condition: Thrombosis

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Total 639 results found since Jan 2013.

In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke
Isr Med Assoc J. 2022 Dec 1;25(12):853-854.ABSTRACTEndovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in con...
Source: The Israel Medical Association Journal - August 16, 2023 Category: General Medicine Authors: Ze'ev Itsekson Hayosh Eiman Abu Bandora Natalia Shelestovich Maya Nulman Mati Bakon Gal Yaniv Boris Khaitovitch Shmuel Balan Alexandra Gerasimova Tali Drori Stefan Mausbach Yvonne Schwammenthal Arnon Afek Joab Chapman Efrat Shavit Stein David Orion Source Type: research

Sudden bilateral anterior cerebral infarction: unusual stroke associated with unusual vascular anomalies
We describe a 38-year-old male smoker and heavy alcohol user, who awoke with sudden onset of weakness of both lower limbs, and bladder and bowel incontinence. He had consumed excessive amounts of alcohol the previous night. There was no significant past medical history including other vascular risk factors and cardiovascular disease. On admission, he was mute and abulic. The frontal release signs including the forced grasping and the snout reflex were present. Routine full blood count and biochemical analysis were normal. MRI of the brain showed bilateral, nearly symmetrical ACA infarction (figure 1A–C). Time-of-flig...
Source: Postgraduate Medical Journal - January 21, 2013 Category: Journals (General) Authors: Krishnan, M., Kumar, S., Ali, S., Iyer, R. S. Tags: Urology, Open access, Drugs: cardiovascular system, Echocardiography, Stroke, Venous thromboembolism, Radiology, Physiotherapy, Sports and exercise medicine, Clinical diagnostic tests, Radiology (diagnostics) Images in medicine Source Type: research

Comment Intermittent pneumatic compression in patients with stroke
A patient with acute stroke has just been admitted who is immobile, and cannot walk to the bathroom without help. Looking at the patient's unmoving legs the risk of thrombosis is clear, but a low molecular weight heparin (LMWH) might lead to bleeding, and elastic compression stockings cause skin problems. So you settle on intermittent pneumatic compression devices (IPCs)—but do they actually prevent blood clots?
Source: LANCET - August 10, 2013 Category: Journals (General) Authors: Scott M Stevens, Scott C Woller Tags: Comment Source Type: research

Correspondence Intermittent pneumatic compression in patients with stroke – Authors' reply
Johann Auer and colleagues question whether intermittent pneumatic compression (IPC) would be as effective if used with prophylactic anticoagulants. The CLOTS 3 trial was done in the UK, where the evidence-based national guidelines do not recommend routine use of anticoagulants for deep vein thrombosis (DVT) prophylaxis after stroke. David Barer highlights that although anticoagulants reduce (mainly asymptomatic) DVT, effects on pulmonary embolism are unclear and the increase in bleeds offsets any benefits, so there is no significant effect on survival or functional outcomes.
Source: LANCET - November 2, 2013 Category: Journals (General) Authors: Martin Dennis, Peter Sandercock, Gordon Murray, John Forbes Tags: Correspondence Source Type: research

Successful bridge to recovery using two-stage HeartWare LVAD explantation approach after embolic stroke
A two-stage explantation of a left ventricular assist device (LVAD) was performed on 47 year old afro-american gentlemen with non-ischemic dilated cardiomyopathy (DCM) who was successfully bridged to recovery. After he suffered a stroke caused by a VAD thrombosis with embolisation, the VAD outflow graft was first ligated using minimally-invasive approach. Two months later, the device was explanted and a manufactured titanium plug was placed into the sewing ring. This stepwise procedure might be beneficial in cases of high thromboembolic risk and in patients who suffered a thromboembolic event previously.
Source: BioMed Central - December 30, 2013 Category: Journals (General) Authors: Anton SabashnikovBenjamin A HögerlePrashant N MohiteAron-Frederik PopovDiana García SáezJavid FatullayevMohamed AmraniThorsten WahlersAndré R SimonToufan Bahrami Source Type: research

Stroke Rounds: Uric Acid Post tPA (CME/CE)
SAN DIEGO (MedPage Today) -- Despite missing its primary endpoint, a randomized trial suggested that giving uric acid after intravenous thrombolytic therapy to patients with acute ischemic stroke might help improve outcomes.
Source: MedPage Today Meeting Coverage - February 13, 2014 Category: Journals (General) Source Type: news

Efforts to reduce the door-to-needle time of thrombolysis in acute ischemic stroke: Video-assisted therapeutic risk communication
Conclusion A thrombolysis program with video-assisted therapeutic risk communication decreased DTN time and increased the treatment rate of patients with AIS.
Source: Journal of the Formosan Medical Association - December 19, 2014 Category: Journals (General) Source Type: research

Asymptomatic atrial fibrillation and risk of stroke.
Authors: Stachon P, Ahrens I, Faber T, Bode C, Zirlik A Abstract The incidence of atrial fibrillation rises with increasing age. About 10% of patients over 80 years suffer from atrial fibrillation, but episodes are often not recognized. However, about 25% of cryptogenic strokes are caused by asymptomatic atrial fibrillation showing a significant risk of thromboembolism by this condition. New insertable cardiac monitors (ICM) or wearable sensors offer the opportunity of continuous rhythm monitoring over wider time spans. Thereby, they enable detection of asymptomatic AF episodes. Several lines of evidence point towa...
Source: Panminerva Medica - January 18, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

Massive pulmonary embolism with acute cor pulmonale
A 51-year-old immobilised man, while recovering at stroke rehabilitation, complained of sudden onset chest pain prior to an unconscious collapse. Observations on arrival were heart rate 120 bpm, blood pressure 80/60 mm Hg and oxygen saturations of 90% on 10 L of oxygen. ECG demonstrated new right bundle branch block (RBBB) with classical S1Q3T3 repolarisation abnormality of acute right heart strain (figure 1A). Urgent CT pulmonary angiogram revealed saddle pulmonary embolism with extensive thrombus burden (figure 1B). Transthoracic echocardiogram (TTE) showed acute right ventricular (RV) overload with c...
Source: Postgraduate Medical Journal - July 25, 2016 Category: Journals (General) Authors: Nelson, A. J., Wong, G. R., Roberts-Thomson, R., Parvar, S. L. Tags: Journalology, Drugs: cardiovascular system, Echocardiography, Pain (neurology), Stroke, Hypertension, Interventional cardiology, Ischaemic heart disease, Venous thromboembolism, Radiology, Pulmonary embolism, Clinical diagnostic tests, Vascular surgery, E Source Type: research

Embolic Stroke Due to Sinus of Valsalva Aneurysm Thrombus.
PMID: 27650243 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - August 31, 2016 Category: Journals (General) Authors: Ruzieh M, Shafiq Q, Murphy L, Bonnell M, Khouri S Tags: Am J Med Sci Source Type: research

Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial
This study is registered with ClinicalTrials.gov, NCT00784134. Findings Between Sept 18, 2009, and Jan 13, 2015, 500 patients were randomised: 249 to the alteplase group and 251 to the saline group. 180-day follow-up data were available for analysis from 246 of 249 participants in the alteplase group and 245 of 251 participants in the placebo group. The primary efficacy outcome was similar in each group (good outcome in alteplase group 48% vs saline 45%; risk ratio [RR] 1·06 [95% CI 0·88–1·28; p=0·554]). A difference of 3·5% (RR 1·08 [95% CI 0·90–1·29], p=0·420) was found after adjustment for intraventricular ...
Source: The Lancet - January 9, 2017 Category: Journals (General) Source Type: research

Ischemic stroke following a wasp sting – a rare complication: a case report
ConclusionTreating physicians should be aware of the rare but possible complication of ischemic stroke following a case of wasp sting.
Source: Journal of Medical Case Reports - October 14, 2018 Category: General Medicine Source Type: research

Hand knob stroke from cancer-associated thromboembolism.
PMID: 31636165 [PubMed - in process]
Source: cmaj - October 20, 2019 Category: General Medicine Authors: Tomoda Y, Tanaka M, Tanaka K Tags: CMAJ Source Type: research

Association Between Thrombolytic Door-to-Needle Times and Ischemic Stroke Outcomes
This cohort study estimates associations between intravenous tissue plasminogen activator (tPA) door-to-needle times of less than 4.5 hours for acute ischemic stroke and 1-year mortality or readmission among Medicare beneficiaries aged 65 years or older.
Source: JAMA - June 2, 2020 Category: General Medicine Source Type: research