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Specialty: Endocrinology
Condition: Stroke
Nutrition: Calcium

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Total 23 results found since Jan 2013.

Higher calcium intake 'may protect seniors from CVD, but not stroke, fractures'
Research presented at the Endocrine Society annual meeting suggests that whilst increased calcium intake may lower the risk of CVD in older adutls, it does not protect against stroke or fractures. Medical News Today
Source: Society for Endocrinology - April 5, 2016 Category: Endocrinology Source Type: news

Racial differences in association of serum calcium with mortality and incident cardio- and cerebrovascular events.
CONCLUSIONS: Race modified the U-shaped association between calcium and all-cause mortality. Serum calcium is not associated with incident stroke or CHD in neither AA nor white patients. The race-specific difference in the association of calcium levels with mortality warrants further examination. PMID: 27631543 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 14, 2016 Category: Endocrinology Authors: Lu JL, Molnar MZ, Ma JZ, George LK, Sumida K, Kalantar-Zadeh K, Kovesdy CP Tags: J Clin Endocrinol Metab Source Type: research

Coffee and tea: perks for health and longevity?
Abstract PURPOSE OF REVIEW: Tea and coffee, after water, are the most commonly consumed beverages in the world and are the top sources of caffeine and antioxidant polyphenols in the American diet. The purpose of this review is to assess the health effects of chronic tea and/or coffee consumption. RECENT FINDINGS: Tea consumption, especially green tea, is associated with significantly reduced risks for stroke, diabetes and depression, and improved levels of glucose, cholesterol, abdominal obesity and blood pressure. Habitual coffee consumption in large epidemiological studies is associated with reduced mortali...
Source: Diabetes Metab - September 25, 2013 Category: Endocrinology Authors: Bhatti SK, O'Keefe JH, Lavie CJ Tags: Curr Opin Clin Nutr Metab Care Source Type: research

Normocalcaemic, vitamin D sufficient hyperparathyroidism ‐ high prevalence and low morbidity in the general population A long‐term follow‐up study, the WHO MONICA project, Gothenburg, Sweden
ConclusionsThis small random population study showed that nHPT was common, 11% at follow‐up. Only one individual developed mild hypercalcaemia in 13 years. Previous S‐PTH was predictive of nHPT and hypertension was prevalent, but no increase in hard end points was seen over a 17‐year period.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - May 18, 2015 Category: Endocrinology Authors: Georgios Kontogeorgos, Penelope Trimpou, Christine M. Laine, Göran Oleröd, Anders Lindahl, Kerstin Landin‐Wilhelmsen Tags: Rapid Communication Source Type: research

Nesfatin-1 as a new positive inotrope in the goldfish (Carassius auratus) heart.
In conclusion, this is the first report showing that in teleosts, Nesfatin-1 potentiates mechanical cardiac performance, strongly supporting the evolutionary importance of the peptide in the control of the cardiac function of vertebrates. PMID: 26248227 [PubMed - as supplied by publisher]
Source: General and Comparative Endocrinology - August 4, 2015 Category: Endocrinology Authors: Mazza R, Gattuso A, Filice M, Cantafio P, Cerra MC, Angelone T, Imbrogno S Tags: Gen Comp Endocrinol Source Type: research

High androgens in postmenopausal women and the risk for atherosclerosis and cardiovascular disease: the Rotterdam Study.
Conclusion: Postmenopausal high androgen levels were not associated with an increased risk for CVD. Cardiovascular health in women with PCOS might be better than was anticipated. PMID: 29408955 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 1, 2018 Category: Endocrinology Authors: Meun C, Franco OH, Dhana K, Jaspers L, Muka T, Louwers Y, Ikram MA, Fauser BCJM, Kavousi M, Laven JSE Tags: J Clin Endocrinol Metab Source Type: research

Oxidative Stress Defines the Neuroprotective or Neurotoxic Properties of Androgens in Immortalized Female Rat Dopaminergic Neuronal Cells.
In this study, we examined the effects of androgens under conditions of oxidative stress to determine whether androgens play a neuroprotective or neurotoxic role in dopamine neuronal function. Mitochondrial function, cell viability, intracellular calcium levels, and mitochondrial calcium influx were examined in response to androgens under both nonoxidative and oxidative stress conditions. Briefly, N27 dopaminergic cells were exposed to the oxidative stressor, hydrogen peroxide, and physiologically relevant levels of T or dihydrotestosterone, applied either before or after oxidative stress exposure. Androgens, alone, increa...
Source: Endocrinology - August 19, 2013 Category: Endocrinology Authors: Holmes S, Abbassi B, Su C, Singh M, Cunningham RL Tags: Endocrinology Source Type: research

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin.
CONCLUSIONSMetformin use was associated with impaired cognitive performance. Vitamin B12 and calcium supplements may alleviate metformin-induced vitamin B12 deficiency and were associated with better cognitive outcomes. Prospective trials are warranted to assess the beneficial effects of vitamin B12 and calcium use on cognition in older people with diabetes who are taking metformin. PMID: 24009301 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 5, 2013 Category: Endocrinology Authors: Moore EM, Mander AG, Ames D, Kotowicz MA, Carne RP, Brodaty H, Woodward M, Boundy K, Ellis KA, Bush AI, Faux NG, Martins R, Szoeke C, Rowe C, Watters DA, the AIBL Investigators Tags: Diabetes Care Source Type: research

Cardiovascular endocrinology: Controversy—cardiovascular effects of calcium supplementation
Nature Reviews Endocrinology 10, 641 (2014). doi:10.1038/nrendo.2014.146 Author: Ian R. Reid Of late, clinical trial data, meta-analyses and observational studies have caused concern that the use of calcium supplements might increase the risk of myocardial infarction and stroke. A new meta-analysis suggests that there is no problem with calcium supplements, but as the analysis includes controversial data omitted from previous analyses, the debate will continue.
Source: Nature Reviews Endocrinology - August 19, 2014 Category: Endocrinology Authors: Ian R. Reid Tags: News and Views Source Type: research

Ultrasonography Reveals In Vivo Dose-Dependent Inhibition of End Systolic and Diastolic Volumes, Heart Rate and Cardiac Output by Nesfatin-1 in Zebrafish.
Abstract Nesfatin-1 is an 82 amino acid peptide that inhibits food intake in rodents and fish. While endogenous nesfatin-1, and its role in the regulation of food intake and hormone secretion has been reported in fish, information on cardiovascular functions of nesfatin-1 in fish is in its infancy. We hypothesized that cardiac NUCB2 expression is meal responsive and nesfatin-1 is a cardioregulatory peptide in zebrafish. NUCB2/nesfatin-1 like immunoreactivity was detected in zebrafish cardiomyocytes. Real-time quantitative PCR analysis found that the cardiac expression of NUCB2A mRNA in unfed fish decreased at 1 ho...
Source: General and Comparative Endocrinology - February 15, 2016 Category: Endocrinology Authors: Nair N, Gerger C, Hatef A, Weber LP, Unniappan S Tags: Gen Comp Endocrinol Source Type: research

Benefits of calcium supplements may be outweighed by cardiovascular risks
A Norweigan study published in Osteoporosis International suggests that the bone-strength benefits of taking calcium and vitamin D supplements may be outweighted by an increased risk of heart attack and stroke. Science Daily
Source: Society for Endocrinology - May 16, 2016 Category: Endocrinology Source Type: news

Associations of 25-hydroxyvitamin D with markers of inflammation, insulin resistance and obesity in black and white community-dwelling adults
Conclusions Lower 25(OH)D concentrations are associated with disturbances in metabolic health in both blacks and whites. Whether correcting vitamin D deficiency could offer a beneficial therapy for disease prevention requires further study.
Source: Journal of Clinical and Translational Endocrinology - July 27, 2016 Category: Endocrinology Source Type: research

Very low-density lipoprotein (VLDL)-induced signals mediating aldosterone production
Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus increasing blood volume and pressure. Excessive production of aldosterone results in high blood pressure and contributes to cardiovascular and renal disease, stroke and visual loss. Hypertension is also associated with obesity, which is correlated with other serious health risks as well. Although weight gain is associated with increased blood pressure, the mechanism by which excess fat deposits increase blood pressure remains unclear. Several studies have suggested that aldosterone levels are elevated with obesity and may represent a lin...
Source: Journal of Endocrinology - January 3, 2017 Category: Endocrinology Authors: Tsai, Y.-Y., Rainey, W. E., Bollag, W. B. Tags: Review Source Type: research

Moderate salt restriction with or without paricalcitol in type 2 diabetes and losartan-resistant macroalbuminuria (PROCEED): a randomised, double-blind, placebo-controlled, crossover trial
This study is registered with ClinicalTrials.gov, number NCT01393808, and the European Union Clinical Trials Register, number 2011-001713-14. Findings Between Dec 13, 2011, and Feb 17, 2015, we randomly allocated 57 (50%) patients to a low-sodium diet (28 [49%] to paricalcitol then placebo and 29 [51%] to placebo then paricalcitol) and 58 (50%) to a high-sodium diet (29 [50%] to paricalcitol then placebo and 29 [50%] to placebo then paricalcitol). In the low-sodium group (30 mEq of daily sodium intake reduction, equivalent to approximately 1·7–1·8 g per day), 24 h albuminuria was reduced by 36·6% (95% CI 28·5–44·9...
Source: The Lancet Diabetes and Endocrinology - November 3, 2017 Category: Endocrinology Source Type: research