Graves’ disease and mental disorders
Publication date: Available online 11 October 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Atsushi Fukao, Junta Takamatsu, Takeshi Arishima, Mika Tanaka, Toshio Kawai, Yasuki Okamoto, Akira Miyauchi, Akihisa ImagawaAbstractMental disorders merge with highly in thyroid diseases. Because of its regulatory effects on serotonin and noradrenalin, T3 has been linked closely to depression and anxiety. It has known that in many cases, the mental symptoms persist even after treatment and after normalization of thyroid function by treatment. Psychosocial factors including stress have been associated wi...
Source: Journal of Clinical and Translational Endocrinology - October 11, 2019 Category: Endocrinology Source Type: research

Type 2 Diabetes Mellitus non-surgical remission: A possible mission
Publication date: Available online 16 August 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Magdy M. Allam, Hanaa T. El-ZawawyAbstractBackgroundRemission of Type 2 diabetes mellitus (DM) has been observed throughout the last few years, yet factors associated with remission through non-surgical approaches are still unclear. So, the factors associated with type 2 DM remission were investigatedMethodsout 670 patients, 63 patients gained non-surgical remission of type 2 DM (defined according to ADA criteria), and 396 patients served as control matched for age, sex, and BMI. The records of patients ...
Source: Journal of Clinical and Translational Endocrinology - August 17, 2019 Category: Endocrinology Source Type: research

Comparison Of Bicarbonate Values From Venous Blood Gas And Chemistry Panels Measured At The Time Of Diagnosis And Resolution Of Diabetes Ketoacidosis
ConclusionDiscordance between bicarbonate results from different analysis methods may lead to different determinations as to whether or not a patient meets the biochemical definition for diagnosis and resolution of DKA. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - August 17, 2019 Category: Endocrinology Source Type: research

Liquid and softgel capsules of l-thyroxine results lower serum thyrotropin levels than tablet formulations in hypothyroid patients
This study aims to fill this gap. The outcome was the degree of TSH change in the liquid and softgel formulations, using tablet LT4 as the reference, regardless of sequence of formulation and regardless of whether patients were co-ingesting the said interfering medications.MethodsWe recorded serum TSH levels in two groups of L-T4 replaced patients with primary hypothyroidism (23 subjects who did not co-ingest interfering medications, and 20 subjects who did). Either group of patients took one formulation of L-T4 at a time with variable sequences. In the first group, the median durations of exposure to tablet, liquid or sof...
Source: Journal of Clinical and Translational Endocrinology - August 7, 2019 Category: Endocrinology Source Type: research

Glycaemic variability is associated with adverse cardiovascular outcomes in patients hospitalised with an acute myocardial infarction
Publication date: Available online 29 July 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Thora Y Chai, Mark McLean, Vincent W. Wong, N. Wah CheungAbstractUnlike admission hyperglycaemia, there is significant controversy surrounding whether acute glycaemic variability is associated with major adverse cardiovascular events (MACE) in patients immediately after an acute myocardial infarction (AMI). We conducted a retrospective post-hoc analysis in an AMI population and determined fluctuating glycaemia is associated with a higher risk of 3-month MACE. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - July 29, 2019 Category: Endocrinology Source Type: research

Assessment of serum thyroid hormone autoantibodies in the first trimester of gestation as predictors of postpartum thyroiditis
ConclusionsGestational positivity of THAb enhance enormously the predictivity for PPT of gestational positivity of TPOAb/TgAb. However, their low frequency (5.1%) and their sensitivity (17.5% [21/63]) go against their application in lieu of TPOAb/TgAb. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - July 24, 2019 Category: Endocrinology Source Type: research

Hypoglycemic symptoms in the absence of diabetes: Pilot evidence of clinical hypoglycemia in young women
Publication date: Available online 24 July 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Morgana Mongraw-Chaffin, Daniel P. Beavers, Donald A. McClainAbstractAimsClinical visits of non-diabetic patients reporting hypoglycemic symptoms are common in endocrinology practices, but remain understudied and lack clinical definition and evidence-based recommendations for diagnosis or treatment. Our goal was to pilot test the concordance of hypoglycemic symptoms with low glucose values in young non-diabetic individuals.MethodsWe recruited eight individuals who reported regularly experiencing symptoms c...
Source: Journal of Clinical and Translational Endocrinology - July 24, 2019 Category: Endocrinology Source Type: research

Publisher Note
Publication date: Available online 31 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - June 1, 2019 Category: Endocrinology Source Type: research

In Experimental Peripheral Arterial Disease, Type 2 Diabetes alters Post-Ischemic gene expression
Publication date: Available online 31 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Rahul Peravali, Lucas Gunnels, Karthik Dhanabalan, Folabi Ariganjoye, Ivan C. Gerling, Ayotunde O. DokunAbstractPeripheral arterial disease is characterized by impaired blood flow to tissues outside the heart due to atherosclerosis and it most frequently occurs in the lower extremities. Type 2 diabetes (T2D) is a well-known risk factor that accelerate the course and contributes to poor clinical outcomes of PAD. While there is some evidence that T2D is associated with altered expression of genes involved in ...
Source: Journal of Clinical and Translational Endocrinology - June 1, 2019 Category: Endocrinology Source Type: research

Dobesity: relationship between vitamin d deficiency, obesity and sclerostin as a novel biomarker of bone metabolism
Publication date: Available online 21 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Eman Zaki Azzam, Mohamed Nabil Ata, Doreen Nazeih Younan, Tarek M. Salem, Ahmed Alaa Abdul-AzizAbstractAimTo study the relationship between obesity, insulin resistance, vitamin D deficiency and sclerostin as a bone biomarker.Materials and methodsCross-section study of 75 subjects grouped into 3 groups; obese (n=31), overweight (n=23) and normal (n=21) subjects. Sclerostin, fasting insulin, fasting plasma glucose and 25(OH)D were measured and anthropometric measures were taken.Results25(OH)D was lower in obe...
Source: Journal of Clinical and Translational Endocrinology - May 22, 2019 Category: Endocrinology Source Type: research

Chemokines in Hyperthyroidism
Publication date: Available online 17 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Silvia Martina Ferrari, Ilaria Ruffilli, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Armando Patrizio, Valeria Mazzi, Alessandro Antonelli, Poupak FallahiAbstractThe term “hyperthyroidism” indicates a condition due to an exaggerate production of thyroid hormone; the most frequent cause is Graves' disease (GD).We review cytokines and chemokines in hyperthyroidism, with a special focus in GD.In GD, recruited Th1 lymphocytes are responsible for enhanced IFN-γ and TNF-α product...
Source: Journal of Clinical and Translational Endocrinology - May 18, 2019 Category: Endocrinology Source Type: research

Bimodal distribution of fasting, one and two hour post load plasma glucose in Asian Indian pregnant women without pre-gestational diabetes: Gestational age related changes
Publication date: Available online 16 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): John Punnose, Rajeev Kumar Malhotra, Komal Sukhija, Anu Mathew, Aditi Chopra, Asha Sharma, Naimaa Choudhary (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 17, 2019 Category: Endocrinology Source Type: research

Urinary Metabolic Profiles after Vitamin D2 versus Vitamin D3 Supplementation in Prediabetes
ConclusionsAt comparable circulating 25(OH)D concentrations, vitamin D2 or D3 supplementation does not appear to result in different urinary metabolite profiles. Our finding does not support a biological difference between vitamin D2 and D3. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 9, 2019 Category: Endocrinology Source Type: research

The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
ConclusionsIn T2DM patients, there is a complex interrelationship among OSA severity, gender and TBS. More severe OSA predicted lower TBS in men, but predicted higher TBS in postmenopausal women. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 3, 2019 Category: Endocrinology Source Type: research

Metabolic Dysfunction in Emirati Subjects in Abu Dhabi: Relationship to Levels of Soluble RAGEs
Publication date: Available online 23 April 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Abdishakur Abdulle, Claire K. Inman, Abdelkarim Saleh, Mohamed Noshi, Divya Galani, Laila Abdelwareth, Habiba Alsafar, Abubaker Elfatih, Hefsa Al Shamsi, Raghib Ali, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt, Mahmoud M. Benbarka, Mohamed H. HassanAbstractBackgroundThe United Arab Emirates is experiencing increasing rates of type 2 diabetes (T2D) and its complications. As soluble levels of the receptor for advanced glycation end products, (sRAGE), and endogenous secretory RAGE (esRAGE), the latte...
Source: Journal of Clinical and Translational Endocrinology - April 24, 2019 Category: Endocrinology Source Type: research

Disparities in prediabetes and type 2 diabetes prevalence between indigenous and nonindigenous populations from Southeastern Mexico: The Comitan Study
ConclusionsThe prevalence of prediabetes and type 2 diabetes was significantly lower in indigenous than in nonindigenous participants. Also, prevalence of type 2 diabetes was lower those living in rural areas. Health benefits of a traditional lifestyle may partially account for these differences. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - April 21, 2019 Category: Endocrinology Source Type: research

Hyperthyroidism in the pregnant woman: maternal and fetal aspects
Publication date: Available online 12 April 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Mariacarla Moleti, Maria Di Mauro, Giacomo Sturniolo, Marco Russo, Francesco VermiglioAbstractHyperthyroidism during pregnancy is uncommon. Nonetheless, prompt identification and adequate management of hyperthyroidism in a pregnant woman is essential, because uncontrolled thyrotoxicosis significantly increases the risk of maternal and fetal complications. Also, fetal prognosis may be affected by the transplacental passage of maternal thyroid stimulating antibodies or thyrostatic agents, both of which may ...
Source: Journal of Clinical and Translational Endocrinology - April 14, 2019 Category: Endocrinology Source Type: research

A minimum of two years of undertreated primary hypothyroidism, as a result of drug-induced malabsorption of L-thyroxine, may have metabolic and cardiovascular consequences
ConclusionDuring a median period of 31 months, there are relevant consequences for L-T4 treated adult hypothyroid patients resulting from hyperthyrotropinemia caused by medications impairing L-T4 absorption. This should be taken into account by future guidelines on hypothyroidism management. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - April 10, 2019 Category: Endocrinology Source Type: research

Clinical Characteristics and Outcomes of Care in Adult Patients with Diabetic Ketoacidosis: A Retrospective Study from a Tertiary Diabetes Center in Thailand
ConclusionsInadequate metabolic monitoring and iatrogenic hypoglycemia remain areas of concern for DKA management. Occurrence of hypokalemia was related to poor adherence to protocol guidance on potassium supplementation. A strengthened educational program for nursing and medical staffs should be emphasized. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - April 10, 2019 Category: Endocrinology Source Type: research

Prevalence of prediabetes and type 2 diabetes in two non-random populations aged 44–77 years in the Faroe Islands
ConclusionsAmong the Faroese populations studied, the prevalence of type 2 diabetes increased with age and was more prevalent among men. The detected prevalence was comparable to other Nordic countries for all age-groups. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - April 3, 2019 Category: Endocrinology Source Type: research

Prevalence of Prediabetes and Type 2 Diabetes in Two Non-Random Populations Aged 44-77 Years in the Faroe Islands
ConclusionsAmong the Faroese populations studied, the prevalence of type 2 diabetes increased with age and was more prevalent among men. The detected prevalence was comparable to other Nordic countries for all age-groups. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - March 22, 2019 Category: Endocrinology Source Type: research

C679X loss-of-function PCSK9 variant is associated with lower fasting glucose in black South African adolescents: Birth to Twenty Plus Cohort
Publication date: Available online 28 February 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Tinashe Chikowore, Venesa Sahibdeen, Liesl M. Hendry, Shane A. Norris, Julia H. Goedecke, Lisa K. Micklesfield, Zané LombardAbstractAimTo evaluate the association between loss-of-function (LOF) PCSK9 variants (A433T/rs28362263 and C679X/rs28362286) and biomarkers of cardiometabolic risk, specfically fasting glucose and low density lipoprotein cholesterol (LDL-C) concentrations.MethodsOur study comprised 757 male and female black South African adolescents (mean age 18.0 ± 0.5 years) who ar...
Source: Journal of Clinical and Translational Endocrinology - March 1, 2019 Category: Endocrinology Source Type: research

Serum Free Thiols in Type 2 Diabetes Mellitus: a Prospective Study
ConclusionsAlthough R-SH concentrations were associated with a favourable disease status, it did not add to the predictive capacity for long-term complications. Based on the current data R-SH seems unsuitable as a prognostic marker in T2DM. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - March 1, 2019 Category: Endocrinology Source Type: research

Gestational Diabetes Mellitus and Macrosomia Predispose to Diabetes in the Lebanese Population
ConclusionIn conclusion, GDM and macrosomia, but not PCOS, are significant risk factors for T2DM in our Lebanese cohort. Our results, reported for the first time in the Middle East, present insights into risk factors management and disease prevention. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - February 21, 2019 Category: Endocrinology Source Type: research

Do community health workers affect non-urgent, ambulatory healthcare utilization among low-income, minority patients with diabetes?
Publication date: Available online 7 February 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Ryan G. Chiu, Yinglin Xia, Lisa K. Sharp, Ben S. GerberAbstractCommunity health workers (CHWs) can reduce emergent care among low-income, ethnic minority patients with type 2 diabetes. A secondary analysis of a randomized controlled trial evaluated the effect of CHWs on non-urgent, ambulatory healthcare utilization. Within this trial, no effect on ambulatory care was found. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - February 8, 2019 Category: Endocrinology Source Type: research

The value of total thyroidectomy as the definitive treatment for Graves’ disease: a single centre experience of 594 cases
ConclusionThis high-volume surgeon experience demonstrates that total thyroidectomy is a safe and effective treatment for Graves’ disease. It is associated with a very low incidence rate of post-operative complications, most of which are transitory; therefore, it offers a rapid and definitive control of hyperthyroidism and its related symptoms. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - February 8, 2019 Category: Endocrinology Source Type: research

Dyslipidemia: the untreated metabolic dysfunction in people with type 2 diabetes in Latin America. ARETAEUS study outcomes
ConclusionDyslipidemia treatment in patients with T2D was delayed despite its known deleterious effect on atherosclerosis development and β-cell mass/function. Anti-hyperglycemic treatment was not intensified when targets were not attained. This prescriptive inertia needs to be corrected because attainment of HbA1c treatment goals becomes more difficult, favoring the development of diabetes complications. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - January 27, 2019 Category: Endocrinology Source Type: research

Thyroid vascularization is an important ultrasonographic parameter in untreated Graves’ disease patients
In conclusion, thyroid hypervascularization at onset of Graves’ disease is an important sonographic feature. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - January 20, 2019 Category: Endocrinology Source Type: research

Relationship Between Depression, Sleep Quality, and Hypoglycemia Among Persons with Type 2 Diabetes
Conclusions:In the Thailand cohort, depressive symptoms were associated with hypoglycemia frequency. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - January 3, 2019 Category: Endocrinology Source Type: research

High frequency of empty sella, with gender differences, in the early neuroradiology evaluation of patients with traumatic brain injury. A prospective study
In conclusion, ES is detectable in almost 40% of persons who undergo CT within 24 h from TBI. A number of intergender differences concerning ES and the hormones evaluated are apparent. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - December 31, 2018 Category: Endocrinology Source Type: research

Metabolic effects of glucagon in humans
Publication date: Available online 20 December 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): María M. Adeva-Andany, Raquel Funcasta-Calderón, Carlos Fernández-Fernández, Elvira Castro-Quintela, Natalia Carneiro-FreireAbstractDiabetes is a common metabolic disorder that involves glucose, amino acids, and fatty acids. Either insulin deficiency or insulin resistance may cause diabetes. Insulin deficiency causes type 1 diabetes and diabetes associated with total pancreatectomy. Glucagon produces insulin resistance. Glucagon-induced insulin resistance promotes type 2 dia...
Source: Journal of Clinical and Translational Endocrinology - December 20, 2018 Category: Endocrinology Source Type: research

Improvement of glycemic control by treatment for insomnia with suvorexant in type 2 diabetes mellitus
ConclusionsSuvorexant treatment for insomnia of subjects with T2DM significantly improved CGM-measured daily glycemic control, which was associated with changes in sympathomimetic tone and/or improved insulin sensitivity. The amelioration of insomnia may therefore be a target for improving glycemic control in T2DM patients with insomnia. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - December 19, 2018 Category: Endocrinology Source Type: research

Incidence and Malignancy Rates Classified by The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) – An 8-year Tertiary Center experience in Thailand
ConclusionsPreoperative diagnosis of thyroid nodules using TBSRTC in our hospital was comparable with other studies. The uniform diagnostic criteria of the Bethesda System help avoid misinterpretation while sharing local experience with international benchmarks. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - December 15, 2018 Category: Endocrinology Source Type: research

Twice-daily insulin glargine for patients with uncontrolled type 2 diabetes mellitus
Publication date: Available online 11 December 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Mohsen Eledrisi, Noor Nabeel Suleiman, Obada Salameh, Mohammad Khair Hamad, Omar Rabadi, Ahmed Mohamed, Rana Al Adawi, Abdul Salam (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - December 12, 2018 Category: Endocrinology Source Type: research

Accuracy of five plasma calibrated glucometers to screen for and diagnose gestational diabetes mellitus in a low resource clinic setting
ConclusionsNot all glucometers may be suitable for GDM screening as only three were accurate compared to the reference test and then only at fasting of the OGTT. Importantly, laboratory fasting glucose was diagnostic of GDM in 80% of cases in this study population. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - December 9, 2018 Category: Endocrinology Source Type: research

Improving the School Experience of Children with Diabetes: Evaluation of the KiDS Project
Publication date: Available online 4 December 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Daniela Chinnici, Angela Middlehurst, Nikhil Tandon, Monika Arora, Anne Belton, Denise Reis Franco, Glaucia Margonari Bechara, Tina Rawal, Radhika Shrivastav, Els Sung, Maeva Germe, David Chaney, David CavanAbstractBackgroundThe International Diabetes Federation (IDF) launched the Kids and Diabetes in School (KiDS) project in collaboration with the International Society for Paediatric and Adolescent Diabetes (ISPAD) and Sanofi Diabetes to inform and teach school staff, children and parents on the manage...
Source: Journal of Clinical and Translational Endocrinology - December 4, 2018 Category: Endocrinology Source Type: research

Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients
Publication date: March 2019Source: Journal of Clinical & Translational Endocrinology, Volume 15Author(s): Hala Ibrahim El Gendy, Noha Adly Sadik, Mona Youssry Helmy, Laila Ahmed RashedAbstractBackgroundVitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control.M...
Source: Journal of Clinical and Translational Endocrinology - December 2, 2018 Category: Endocrinology Source Type: research

Higher Hemoglobin A1C and Atherogenic Lipoprotein Profiles in Children and Adolescents with Type 2 Diabetes Mellitus
Publication date: Available online 30 November 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): James Heath Pelham, Lynae Hanks, Stella Aslibekyan, Shima Dowla, Ambika P. AshrafAbstractAimSignificant knowledge gaps exist regarding lipoprotein profiles in children with type 2 diabetes mellitus (T2DM). The primary objective was to analyze the type and nature of lipoprotein abnormalities present in children with T2DM and to identify determinants of adverse lipoprotein profiles. The secondary objective was to assess associations with elevated glycated hemoglobin (HbA1C), i.e.,
Source: Journal of Clinical and Translational Endocrinology - December 1, 2018 Category: Endocrinology Source Type: research

Vitamin D Receptor Gene Polymorphisms and 25 (OH) Vitamin D: lack of association to Glycemic Control and Metabolic parameters in Type 2 Diabetic Egyptian Patients
Publication date: Available online 29 November 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Hala Ibrahim El Gendy, Noha Adly Sadik, Mona youssry helmy, Laila Ahmed RashedAbstractBackgroundVitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycem...
Source: Journal of Clinical and Translational Endocrinology - November 29, 2018 Category: Endocrinology Source Type: research

Relatively high rate of postpartum thyroiditis in the Straits of Messina area. Predictivity of both postpartum thyroiditis and permanent hypothyroidism by performing, in the first trimester of gestation, thyroid ultrasonography and measurement of serum thyroperoxidase and thyroglobulin autoantibodies
Publication date: Available online 23 November 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Salvatore Benvenga, Flavia Di Bari, Roberto Vita, Maria Le Donne, Onofrio Triolo, Roberta Granese, Irene Borrielli, Giuseppe Sole, Marco Floridia, Filippo Genovesi, Domitilla Tromba, Domenico TrombaAbstractThe prevalence of postpartum thyroiditis (PPT) averages 5%, with a range from 1% (Thailand) to 22% (Wales, UK, and Liguria, Italy), but 3.6% in another Italian region (Puglia). Evolution of PPT into permanent hypothyroidism (PH) occurs in approximately 50% of cases. Positive thyroperoxidase autoantib...
Source: Journal of Clinical and Translational Endocrinology - November 23, 2018 Category: Endocrinology Source Type: research

Type 1 Diabetes alters Ischemia-induced Gene Expression
Publication date: Available online 22 November 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Rahul Peravali, Lucas Gunnels, Satyanarayana Alleboina, Ivan C. Gerling, Ayotunde O. DokunAbstractPeripheral Artery Disease (PAD) is a chronic, activity-limiting disease that is caused by atherosclerotic occlusion of blood vessels outside the heart. Type 1 Diabetes (T1D) not only increases an individual’s likelihood of developing PAD, but also contributes to poor clinical outcomes after PAD manifestation. Although there is some evidence suggesting that hyperglycemia might alter expression of gene...
Source: Journal of Clinical and Translational Endocrinology - November 22, 2018 Category: Endocrinology Source Type: research

How does neural monitoring help during thyroid sugery for Graves’ disease?
Publication date: Available online 20 November 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Le Zhou, Gianlorenzo Dionigi, Alessandro Pontin, Antonella Pino, Ettore Caruso, Che-Wei Wu, Hui Sun, Ralph P. Tufano, Hoon Yub KimAbstractWe evaluate the role of intraoperative neuromonitoring (IONM) in thyroidectomy performed for Graves’ disease (GD) with an emphasis on recurrent laryngeal nerve (RLN) management and completeness of resection. The study is a retrospective series comprising 55 thyroidectomy (control group) versus 82 procedures with intermittent IONM (I-IONM) and 72 by means of con...
Source: Journal of Clinical and Translational Endocrinology - November 21, 2018 Category: Endocrinology Source Type: research

Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?
Publication date: March 2019Source: Journal of Clinical & Translational Endocrinology, Volume 15Author(s): Leonid N. Maslov, Natalia V. Naryzhnaya, Alla A. Boshchenko, Sergey V. Popov, Vladimir V. Ivanov, Peter R. OeltgenAbstractMetabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of leptin, MCP-1, IL-6, and TNF-α by adipocytes. It was established that oxidative stress indu...
Source: Journal of Clinical and Translational Endocrinology - November 17, 2018 Category: Endocrinology Source Type: research

Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?”
Publication date: Available online 9 November 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Leonid N. Maslov, Natalia V. Naryzhnaya, Alla A. Boshchenko, Sergey V. Popov, Vladimir V. Ivanov, Peter R. OeltgenAbstractMetabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of leptin, MCP-1, IL-6, and TNF-α by adipocytes. It was established that oxidative ...
Source: Journal of Clinical and Translational Endocrinology - November 11, 2018 Category: Endocrinology Source Type: research

Gender-Specific Correlation Of Intranodular Chronic Lymphocytic Thyroiditis With Thyroid Nodule Size, Echogenicity, And Histologically-Verified Cytological Class Of Malignancy Risk
Publication date: Available online 25 October 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Salvatore Arena, Salvatore BenvengaAbstractNo data are available on the cytologically and histologically demonstrated presence of intranodular chronic lymphocytic thyroiditis (ICLT) and on the ICLT relationship with thyroid nodule characteristics such as size, echotexture and nature (benign or malignant). We wished to fill this gap by analyzing data in a gender-specific fashion. We studied 408 thyroid nodules from 408 consecutive persons (325 females and 83 males). Nodules were isoechoic (n=268) or hypo...
Source: Journal of Clinical and Translational Endocrinology - October 26, 2018 Category: Endocrinology Source Type: research

A higher blood glucose level pre-breakfast in comparison to bedtime is a contraindication for intensification of prandial insulin therapy in patients with type 2 diabetes – the impact of a negative BeAM value
Publication date: Available online 23 October 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Thorsten Siegmund, Anja Borck, Ariel Zisman, Peter Bramlage, Stephan KressAbstractAimsThe BeAM value refers to the difference between a patient’s blood glucose level at bedtime (Be) and the following morning before breakfast (AM). The clinical impact of a negative BeAM value (AM blood glucose reading compared to that taken at bedtime) is unknown.MethodsT2DM patients the OPAL and POC trials were pooled and their BeAM values calculated.ResultsFrom a total of 358 patients, 31 were calculated as havin...
Source: Journal of Clinical and Translational Endocrinology - October 24, 2018 Category: Endocrinology Source Type: research

Bone turnover and bone mineral density in old persons with type 2 diabetes
Publication date: Available online 24 September 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): João Martin Martins, Patrícia AranhaAbstractAimsTo understand the paradox of an increased fracture risk despite increased bone mineral density (BMD) in persons with type 2 diabetes (DM2).Patients and MethodsWe studied 80 old persons with DM2. Mineral metabolism, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), bone turnover – osteocalcin, procollagen type 1 N-terminal propeptide (P1NP) and C-terminal telopeptide of type 1 collagen (CTX) - were measured and BMD was assessed a...
Source: Journal of Clinical and Translational Endocrinology - October 5, 2018 Category: Endocrinology Source Type: research

Less known aspects of central hypothyroidism: part 1 – acquired etiologies
Publication date: Available online 26 September 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Salvatore Benvenga, Marianne Klose, Roberto Vita, Ulla Feldt-RasmussenAbstractCentral hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophy...
Source: Journal of Clinical and Translational Endocrinology - October 5, 2018 Category: Endocrinology Source Type: research

Perception of Peri-menopausal and Postmenopausal Lebanese Women on Osteoporosis: A Cross-sectional Study
Publication date: Available online 3 October 2018Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Hala Ahmadieh, Ahmad Basho, Amal Chehade, Adeeb Al Mallah, Ahmad DakourAbstractIntroductionOsteoporosis is a generalized skeletal disorder characterized by decreased bone mineral density and microarchitectural deterioration, resulting in increased susceptibility to fractures. The prevalence of osteoporosis in Lebanon, defined as T-score
Source: Journal of Clinical and Translational Endocrinology - October 5, 2018 Category: Endocrinology Source Type: research

Less known aspects of central hypothyroidism: Part 2 – Congenital etiologies
Publication date: December 2018Source: Journal of Clinical & Translational Endocrinology, Volume 14Author(s): Salvatore Benvenga, Marianne Klose, Roberto Vita, Ulla Feldt-RasmussenAbstractCentral hypothyroidism (CH) occurs approximately in 1:50,000, and therefore is expected to be one thousand times rarer compared with primary hypothyroidism. Despite its rarity in the general population, it is much more common in certain disorders, in which it is frequently associated with other pituitary hormone deficiencies. The aim of this paper is to provide an updated review on the frequency of congenital CH, which is
Source: Journal of Clinical and Translational Endocrinology - October 5, 2018 Category: Endocrinology Source Type: research