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Guidelines for the Intravenous Application of Recombinant Tissue-type Plasminogen Activator (Alteplase), the Second Edition, October 2012: A Guideline From the Japan Stroke Society
In Japan, intravenous alteplase, a recombinant tissue-type plasminogen activator (rt-PA), was approved for an indication of ischemic stroke in 2005 on the basis of the results of a clinical trial with a unique dose of the drug (0.6 mg/kg). The Japan Stroke Society published the guidelines for intravenous application of rt-PA and organized training sessions for proper use all over Japan in an effort to promote the safe, widespread use of intravenous alteplase. Seven years following its approval, clinical experience with intravenous alteplase has accumulated, additional evidence of intravenous alteplase has been found in Jap...
Source: Journal of Stroke and Cerebrovascular Diseases - June 3, 2013 Category: Neurology Authors: Kazuo Minematsu, Kazunori Toyoda, Teruyuki Hirano, Kazumi Kimura, Rei Kondo, Etsuro Mori, Jyoji Nakagawara, Nobuyuki Sakai, Yoshiaki Shiokawa, Norio Tanahashi, Masahiro Yasaka, Yasuo Katayama, Susumu Miyamoto, Akira Ogawa, Makoto Sasaki, Sadao Suga, Taken Tags: Original Articles Source Type: research

Review of Therapeutic Electrical Stimulation for Dorsiflexion Assist and Orthotic Substitution From the American Congress of Rehabilitation Medicine Stroke Movement Interventions Subcommittee
This article provides clinicians with information to guide them in the use of electrical stimulation orthotic substitute devices, discusses current research about the use of electrical stimulation orthotic substitute devices for therapeutic and orthotic purposes, and compares the use of electrical stimulation orthotic substitute devices and AFOs. There is insufficient evidence thus far to conclude that walking with an electrical stimulation orthotic substitute device is superior to walking with an AFO, but electrical stimulation orthotic substitute devices may be the optimal choice for some patients.
Source: Archives of Physical Medicine and Rehabilitation - November 8, 2013 Category: Rehabilitation Authors: Pamela Rogers Bosch, Jocelyn E. Harris, Kay Wing, American Congress of Rehabilitation Medicine (ACRM) Stroke Movement Interventions Subcommittee Tags: Clinical Management Review Source Type: research

Establishing the First Mobile Stroke Unit in the United States Special Reports
Conclusion— The first MSU in the United States has been introduced in Houston, TX. The steps needed to accomplish this are described.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Parker, S. A., Bowry, R., Wu, T.-C., Noser, E. A., Jackson, K., Richardson, L., Persse, D., Grotta, J. C. Tags: CT and MRI, Thrombolysis Special Reports Source Type: research

Stroke systems of care in the Philippines: Addressing gaps and developing strategies
In the Philippines, the mortality from stroke during the last 10 years remains high. This paper aims to describe the gaps in stroke care and the development of stroke systems of care in the Philippines. Gaps in stroke systems of care include low number of neurologist, inadequate CT scan machines, lack of stroke training among health workers, lack of stroke protocols and pathways, poor community stroke awareness, low government insurance coverage with high out of pocket medical expenses, lack of infrastructure for EMS, inadequate acute stroke ready hospitals, stroke units and rehabilitation facilities. Although there are go...
Source: Frontiers in Neurology - November 24, 2022 Category: Neurology Source Type: research

Impact of intensive rehabilitation on long-term prognosis after stroke: A Korean nationwide retrospective cohort study
This study emphasizes the importance of intensive rehabilitation in these patients.
Source: Medicine - September 23, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Task-Oriented Circuit Training for Mobility in Outpatient Stroke Rehabilitation in Germany and Austria: A Contextual Transferability Analysis.
Abstract People with stroke cite mobility deficits as one of the most burdensome limitations. National and international stroke guidelines recommend physical therapy based on task-oriented practice, with high numbers of repetitions to improve mobility. In the outpatient setting in Germany and Austria, these principles have not yet been established. The purpose of this study was to identify an evidence-based intervention that could help reduce this research-practice gap. A stepwise approach proposed by Voigt-Radloff et al and Cochrane Germany was used. First, the specific health service problem in the German and Au...
Source: Physical Therapy - April 6, 2020 Category: Physiotherapy Authors: Diermayr G, Schomberg M, Greisberger A, Elsner B, Gronwald M, Salbach NM Tags: Phys Ther Source Type: research

A review of therapeutic electrical stimulation for dorsiflexion assist and for orthotic substitution from the ACRM Stroke Movement Interventions Subcommittee.
Abstract Ankle dorsiflexion weakness that impedes walking affects some 30 percent of people after a stroke, increasing the risk of falls and mortality. Recent advances in functional electrical stimulation or in electrical stimulation orthotic-substitute (eSOS) walking devices facilitate the use of surface electrode stimulation during therapeutic gait training and as an orthotic substitute. However, many therapists who could promote the use of these eSOS devices are not doing so, possibly due to a lack of knowledge about the devices and uncertainty about which patients could benefit from the devices, but also due t...
Source: Medical Physics - November 5, 2013 Category: Physics Authors: Bosch PR, Harris JE, Wing MK Tags: Arch Phys Med Rehabil Source Type: research

Extreme Heat Is Endangering America ’ s Workers —And Its Economy
This project was supported by the Pulitzer Center 7 A.M.: COPELAND FARMS—ROCHELLE, GA Just after dawn on a recent July day in Rochelle, Ga., Silvia Moreno Ayala steps into a pair of sturdy work pants, slips on a long-sleeved shirt, and slathers her face and hands with sunscreen. She drapes a flowered scarf over her wide-brimmed hat to protect her neck and back from the punishing rays of the sun. There isn’t much she can do about the humidity, however. Morning is supposed to be the coolest part of the day, but sweat is already pooling in her rubber boots. [time-brightcove not-tgx=”true”] ...
Source: TIME: Health - August 3, 2023 Category: Consumer Health News Authors: Aryn Baker / Georgia Tags: Uncategorized climate change Climate Is Everything feature healthscienceclimate Source Type: news

Can You Think Yourself Into A Different Person?
For years she had tried to be the perfect wife and mother but now, divorced, with two sons, having gone through another break-up and in despair about her future, she felt as if she’d failed at it all, and she was tired of it. On 6 June 2007 Debbie Hampton, of Greensboro, North Carolina, took an overdose of more than 90 pills – a combination of ten different prescription drugs, some of which she’d stolen from a neighbor’s bedside cabinet. That afternoon, she’d written a note on her computer: “I’ve screwed up this life so bad that there is no place here for me and nothing I can contr...
Source: Science - The Huffington Post - November 19, 2015 Category: Science Source Type: news

Ritalin Could Trigger Heart Problems In Children
Ritalin and similar forms of ADHD medication may trigger abnormal heart rhythms and increase heart attack risk in some children soon after they start taking the drug, according to a new study.  This connection was especially true for children who were born with heart disease. According to the study, published in the British medical journal BMJ, kids had an increased risk of heart attack between eight and 56 days after starting methylphenidate, a stimulant most commonly sold as Ritalin, although this heightened risk didn’t reach statistical significance. The researchers could find no evidence of a heightened...
Source: Science - The Huffington Post - June 8, 2016 Category: Science Source Type: news

4 Key Insights When Raising Money for Your Medtech Startup: Interview with Bruce Shook, CEO of Intact Vascular
Welcome to the Medsider interview series, a regular feature at MassDevice. All interviews are conducted by Scott Nelson, Founder of Medsider and Group Director for WCG. We hope you enjoy them! Bruce Shook joined Intact Vascular in 2014 as President and CEO. A highly-experienced, medical device executive with more than 30 years of industry experience, Bruce was previously Co-founder, Director, President, and CEO of Neuronetics, which is a privately held medical device company that markets a non-invasive brain stimulation technology for the treatment of depression. Previously, Shook was Co-founder, Director, President, an...
Source: Mass Device - February 27, 2017 Category: Medical Equipment Authors: Danielle Kirsh Tags: Blog medsider Source Type: news

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols.
Authors: Wilcock D, Jicha G, Blacker D, Albert MS, D'Orazio LM, Elahi FM, Fornage M, Hinman JD, Knoefel J, Kramer J, Kryscio RJ, Lamar M, Moghekar A, Prestopnik J, Ringman JM, Rosenberg G, Sagare A, Satizabal CL, Schneider J, Seshadri S, Sur S, Tracy RP, Yasar S, Williams V, Singh H, Mazina L, Helmer KG, Corriveau RA, Schwab K, Kivisäkk P, Greenberg SM, MarkVCID Consortium Abstract The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple ...
Source: The Journal of Alzheimers Association - January 24, 2021 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

If you could propose one idea to help improve health care delivery in the United States, what would it be?
Thumbnail: Tags: conversationsphrma conversationslarry hausnermyrl weinbergchris hansennancy brownContributors: 11621161115911631173Contributions: Read Larry Hausner's bio Despite the rapid development of innovative technologies in the health care field, we have yet to discover a panacea that will easily transform our health care system into one that provides high-quality and cost-effective care.  What we have discovered and come to agree on over the last decade is that our sick care system must be reconfigured to a health care system that emphasizes wellness and prevention.  For that reason, I offer ...
Source: PHRMA - June 24, 2013 Category: Pharmaceuticals Authors: rlowe Source Type: news

Suitability of the 6CIT as a screening test for dementia in primary care patients.
Conclusion: The 6CIT's psychometric properties in a real-world setting suggest that the test is not suited as a routine screening instrument. Factors inherent to screening in primary care likely contributed to its low reliability and validity. This highlights the need for training GPs in the conduct of cognitive screening before such procedures can be implemented on a routine basis. PMID: 24256425 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - November 20, 2013 Category: Geriatrics Authors: Hessler J, Brönner M, Etgen T, Ander KH, Förstl H, Poppert H, Sander D, Bickel H Tags: Aging Ment Health Source Type: research

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