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Specialty: Neuroscience
Condition: ALS

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Total 24 results found since Jan 2013.

Peculiarities of Neurological Disorders and Study Designs.
The objectives of treatments of neurodegenerative disorders include primary prevention, slowing or arrest of disease progression, and control of symptoms. Stroke is an acute clinical condition causing frequent disability and death, with only one approved treatment. There are many challenges to acute stroke clinical trials; among them, the very short therapeutic window and the issue of stroke heterogeneity. In this chapter, only the core elements of the study designs are outlined. KEY MESSAGES: The design of an RCT must be adapted to the basic characteristics of each clinical condition. PMID: 27463686 [PubMed - in process]
Source: Frontiers of Neurology and Neuroscience - July 29, 2016 Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research

Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases
Neurochem Res. 2022 Apr 5. doi: 10.1007/s11064-022-03591-3. Online ahead of print.ABSTRACTThe medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and anti-inflammatory properties. It is a well-established drug in Ayurveda and has been widely used for the treatment of neurological disorders and male infertility for ages. The seeds of the plant have potent medicinal value and its extract has been tested in different models of neurodegenerative diseases, especially Parkinson's disease (PD). Apart from PD, Mucuna pruriens is now being studied in models of other nervous systems disorders such as Al...
Source: Neurochemical Research - April 5, 2022 Category: Neuroscience Authors: Walia Zahra Hareram Birla Saumitra Sen Singh Aaina Singh Rathore Hagera Dilnashin Richa Singh Priyanka Kumari Keshri Priyanka Gautam Surya Pratap Singh Source Type: research

Membrane‐type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases
We previously reported that glioma cells induce the expression of membrane‐type 1 metalloproteinase (MT1‐MMP or MMP‐14) in tumor‐associated microglia/macrophages and promote tumor growth, whereas MMP‐14 expression in microglia under physiological conditions is very low. Here, we show that the increase in MMP‐14 expression is also found in microglia/macrophages associated with neurodegenerative and neuroinflammatory pathologies in mouse models as well as in human biopsies or post‐mortem tissue. We found that microglial/macrophage MMP‐14 expression was upregulated in Alzheimer's disease tissue, in active lesi...
Source: Journal of Neuroscience Research - December 10, 2013 Category: Neuroscience Authors: Anika Langenfurth, Jan Leo Rinnenthal, Katyayni Vinnakota, Vincent Prinz, Anne‐Sophie Carlo, Christine Stadelmann, Volker Siffrin, Susann Peaschke, Matthias Endres, Frank Heppner, Rainer Glass, Susanne A. Wolf, Helmut Kettenmann Tags: Research Article Source Type: research

The interplay between microRNAs and histone deacetylases in neurological diseases
Publication date: November 2014 Source:Neurochemistry International, Volume 77 Author(s): Megan W. Bourassa , Rajiv R. Ratan Neurological conditions, such as Alzheimer’s disease and stroke, represent a prevalent group of devastating illnesses with few treatments. Each of these diseases or conditions is in part characterized by the dysregulation of many genes, including those that code for microRNAs (miRNAs) and histone deacetylases (HDACs). Recently, a complex relationship has been uncovered linking miRNAs and HDACs and their ability to regulate one another. This provides a new avenue for potential therapeutics as the ...
Source: Neurochemistry International - November 4, 2014 Category: Neuroscience Source Type: research

The pathophysiological role of astrocytic endothelin-1
Publication date: Available online 28 April 2016 Source:Progress in Neurobiology Author(s): Stéphanie Hostenbach, Miguel D’haeseleer, Ron Kooijman, Jacques De Keyser In the normal central nervous system, endothelin-1 (ET-1) is found in some types of neurons, epithelial cells of the choroid plexus, and endothelial cells of microvessels, but it is usually not detectable in glial cells. However, in different pathological conditions, astrocytes adapting a reactive phenotype express high levels of ET-1 and its receptors, mainly the ETB receptor. ET-1 released by reactive astrocytes appears mainly to have neurodeleterio...
Source: Progress in Neurobiology - April 28, 2016 Category: Neuroscience Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Toward gaze-independent brain-computer interfaces
The ability to communicate by speech, text or gestures is essential to human interaction. This ability is impaired in many people who are affected by debilitating neuromuscular disorders such as amyotrophic lateral sclerosis (ALS), brainstem stroke, or spinal cord injury. Conventional assistive devices (e.g., letter boards, cheek or tongue switches, or eye trackers) that aim to restore communication functions all require muscular control, which is often lost in the progress of neuromuscular disorders.
Source: Clinical Neurophysiology - March 6, 2013 Category: Neuroscience Authors: Peter Brunner, Gerwin Schalk Tags: Editorials Source Type: research

An automated and fast approach to detect single-trial visual evoked potentials with application to brain–computer interface
Brain–computer interface (BCI) is an emerging technology which can establish a pathway between the human brain and computers through recording and decoding brain activity (Wolpaw et al., 2002). Since the control of BCI system is directly based on the recorded brain activity without the involvement of neuromuscular system, it allows people who suffer from motor dysfunction or impairment (e.g., amyotrophic lateral sclerosis, brainstem stroke, and spinal cord injury) to communicate with the external world or control prosthesis (Vaughan et al., 2003).
Source: Clinical Neurophysiology - April 10, 2014 Category: Neuroscience Authors: Yiheng Tu, Yeung Sam Hung, Li Hu, Gan Huang, Yong Hu, Zhiguo Zhang Source Type: research

A region-based two-step P300-based brain–computer interface for patients with amyotrophic lateral sclerosis
The brain–computer interface (BCI) or brain–machine interface (BMI) is an interface technology that enables communication with others and control of the environment or of a prosthesis without any muscle movement (Wolpaw et al., 2002; Birbaumer and Cohen, 2007; Daly and Wolpaw, 2008). In this decade, the use of BCI technology has become widespread, mainly for preclinical research, due to technical and mechanical improvements, and new technology been designed to help individuals with severe neurological disabilities, especially motor difficulties such as amyotrophic lateral sclerosis (ALS), spinal cord injury (SCI), and cerebral stroke.
Source: Clinical Neurophysiology - March 24, 2014 Category: Neuroscience Authors: Shiro Ikegami, Kouji Takano, Kiyohiko Kondo, Naokatsu Saeki, Kenji Kansaku Source Type: research

An automated and fast approach to detect single-trial visual evoked potentials with application to brain–computer interface
Brain–computer interface (BCI) is an emerging technology which can establish a pathway between the human brain and computers through recording and decoding brain activity (Wolpaw et al., 2002). Since the control of BCI system is directly based on the recorded brain activity without the involvement of neuromuscular system, it allows people who suffer from motor dysfunction or impairment (e.g., amyotrophic lateral sclerosis, brainstem stroke, and spinal cord injury) to communicate with the external world or control prosthesis (Vaughan et al., 2003).
Source: Clinical Neurophysiology - April 14, 2014 Category: Neuroscience Authors: Yiheng Tu, Yeung Sam Hung, Li Hu, Gan Huang, Yong Hu, Zhiguo Zhang Source Type: research

A region-based two-step P300-based brain–computer interface for patients with amyotrophic lateral sclerosis
The brain–computer interface (BCI) or brain–machine interface (BMI) is an interface technology that enables communication with others and control of the environment or of a prosthesis without any muscle movement (Wolpaw et al., 2002; Birbaumer and Cohen, 2007; Daly and Wolpaw, 2008). In this decade, the use of BCI technology has become widespread, mainly for preclinical research, due to technical and mechanical improvements, and new technology been designed to help individuals with severe neurological disabilities, especially motor difficulties such as amyotrophic lateral sclerosis (ALS), spinal cord injury (SCI), and cerebral stroke.
Source: Clinical Neurophysiology - March 26, 2014 Category: Neuroscience Authors: Shiro Ikegami, Kouji Takano, Kiyohiko Kondo, Naokatsu Saeki, Kenji Kansaku Source Type: research

Wikipedia and neurological disorders
Publication date: July 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 7 Author(s): Francesco Brigo , Stanley C. Igwe , Raffaele Nardone , Piergiorgio Lochner , Frediano Tezzon , Willem M. Otte Our aim was to evaluate Wikipedia page visits in relation to the most common neurological disorders by determining which factors are related to peaks in Wikipedia searches for these conditions. Millions of people worldwide use the internet daily as a source of health information. Wikipedia is a popular free online encyclopedia used by patients and physicians to search for health-related information. The following Wi...
Source: Journal of Clinical Neuroscience - May 31, 2015 Category: Neuroscience Source Type: research

Multiple faces of protein interacting with C kinase 1 (PICK1): structure, function, and diseases
Publication date: Available online 9 March 2016 Source:Neurochemistry International Author(s): Yun-Hong Li, Nan Zhang, Ya-Nan Wang, Ying Shen, Yin Wang Protein interacting with C-kinase 1 (PICK1) has received considerable attention because it is the only protein that contains both PSD-95/DlgA/ZO-1 (PDZ) domain and Bin-Amphiphysin-Rvs (BAR) domain. Through PDZ and BAR domains, PICK1 binds to a large number of membrane proteins and lipid molecules, and is thereby of multiple functions. PICK1 is widely expressed in various tissues, particularly abundant in the brain and testis. In the central nervous system (CNS), PICK...
Source: Neurochemistry International - March 9, 2016 Category: Neuroscience Source Type: research

Myeloperoxidase: Bridging the gap in Neurodegeneration
Publication date: Available online 22 June 2016 Source:Neuroscience & Biobehavioral Reviews Author(s): R.S. Ray, Anju Katyal Neurodegenerative conditions present a group of complex disease pathologies mostly due to unknown aetiology resulting in neuronal death and permanent neurological disability. Any undesirable stress to the brain, disrupts homeostatic balance, through a remarkable convergence of pathophysiological changes and immune dysregulation. The crosstalk between inflammatory and oxidative mechanisms results in the release of neurotoxic mediators apparently spearheaded by myeloperoxidase derived from ...
Source: Neuroscience and Biobehavioral Reviews - June 22, 2016 Category: Neuroscience Source Type: research