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Specialty: Neurology
Condition: Patent Foramen Ovale

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Total 305 results found since Jan 2013.

Reprint of : Transcatheter closure of patent foramen ovale to prevent stroke recurrence in patients with otherwise unexplained ischaemic stroke: Expert consensus of the French Neurovascular Society and the French Society of Cardiology.
CONCLUSIONS: Although a big step forward that will benefit many patients has been taken with recent trials, many questions remain unanswered. Pending results from further studies, decision-making regarding management of patients with PFO-associated ischaemic stroke should be based on a close coordination between neurologists/stroke specialists and cardiologists. PMID: 31787326 [PubMed - as supplied by publisher]
Source: Revue Neurologique - December 5, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

The Evolving Concept of Cryptogenic Stroke
This article discusses cryptogenic stroke and the results of recent randomized trials that can inform its evaluation and management. RECENT FINDINGS Most cryptogenic strokes appear embolic, leading to the term embolic stroke of undetermined source. It was previously thought that embolic stroke of undetermined source was a single, therapeutically relevant entity, the underlying sources of which would respond to anticoagulant therapy; however, two large randomized trials found no benefit with anticoagulation compared to antiplatelet therapy for secondary stroke prevention after embolic stroke of undetermined source. A sin...
Source: CONTINUUM: Lifelong Learning in Neurology - April 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Prevalence of patent foramen ovale in cryptogenic transient ischaemic attack and non-disabling stroke at older ages: a population-based study, systematic review, and meta-analysis
Publication date: Available online 7 June 2018 Source:The Lancet Neurology Author(s): Sara Mazzucco, Linxin Li, Lucy Binney, Peter M Rothwell Background Percutaneous closure of patent foramen ovale (PFO) has been shown to be superior to medical treatment alone for prevention of recurrent stroke after cryptogenic transient ischaemic attack or non-disabling stroke in patients aged 60 years or younger. The justification for trials in older patients with transient ischaemic attack or stroke depends on whether PFO is shown to be associated with cryptogenic events at older ages, for which existing evidence is conflicting, and o...
Source: The Lancet Neurology - June 8, 2018 Category: Neurology Source Type: research

Clinical Outcomes after Intravenous Fibrinolysis in Cryptogenic Strokes with or without Patent Foramen Ovale
Conclusions: Paradoxical strokes had better outcomes after IV fibrinolysis than other ischemic stroke subtypes, but this difference is attributable to younger age and milder stroke severity on presentation.
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2013 Category: Neurology Authors: Jason J. Chang, Tracy Chiem, Yazan J. Alderazi, Kristina Chapple, Lucas Restrepo Tags: Original Articles Source Type: research

Clinical Characteristics of PFO Stroke in Pregnancy (P2.274)
CONCLUSIONS: PFO may pose unique risks compared to non-PFO related stroke in pregnancy. Novel risk factors such as May-Thurner’s anatomy, which promote venous clotting with the increase in abdominal girth are important during pregnancy. For high risk individuals (such as those with known hypercoagulable state), screening for PFO may be of clinical utility in preventing strokes. Further studies are ongoing to validate these preliminary findings. Study Supported by: None.Disclosure: Dr. Chen has nothing to disclose. Dr. Deng has nothing to disclose. Dr. Wickham has nothing to disclose. Dr. McMullin D has nothing to dis...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Chen, L., Deng, W., Wickham, T., McMullin D, D., Eng H, L., Buonanno, F., Ning, M. Tags: Cerebrovascular Disease and Interventional Neurology: PFO and Other Cardiac Disease Source Type: research

ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden
ConclusionADAMTS-13 activity is inversely correlated with the number of vascular risk factors across different stroke etiologies. Further study is warranted to establish ADAMTS-13 as a mediator of cerebrovascular risk.
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research

Utility of Pelvic MRV in Evaluation of Patients with Cryptogenic Stroke and PFO (P4.228)
CONCLUSIONS: Our data expands on prior study showing that pelvic MRV has the potential to identify a stroke source in patients with cryptogenic stroke, absent identifiable hypercoagulability state, and PFO.Disclosure: Dr. Osgood has nothing to disclose. Dr. Budman has nothing to disclose. Dr. Henninger has received personal compensation for activities with Brainsgate as a consultant.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Osgood, M., Budman, E., Henninger, N. Tags: Cerebrovascular Disease and Interventional Neurology: Cardiac Source Type: research

Effect of Patent Foramen Ovale (PFO) Endovascular Closure on Stroke Quality of Life (P4.229)
Conclusion: PFO stroke patients have improved quality of life after PFO closure as measured by validated quantitative anxiety and depression scales under multi-disciplinary care. Patient’s stress hormone levels were also lowered post PFO closure. These findings demonstrate the importance of a multi-disciplinary approach to stroke patient care, and individualizing care in younger stroke patients. Longer term future studies are needed to understand the effect of PFO closure vs multi-disciplinary specialized care.Study Supported by: NIH/NINDSDisclosure: Dr. K has nothing to disclose. Dr. Ning has nothing to disclose. Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: K, F.-H., Ning, M., Deng, W., Wickham, T., Inglessis, I., Lo, E., Palacios, I., Buonanno, F. Tags: Cerebrovascular Disease and Interventional Neurology: Cardiac Source Type: research

Prevalence of Patent Foramen Ovale in Ischaemic Stroke in Italy: Results of SISIFO Study
Conclusion: If any relationship exists between stroke and PFO, this is more likely in PACI and POCI at a younger age. Our results are consistent with recent findings that underline PFO alone must not be considered a significant independent predictor for stroke; so the presence of PFO alone doesn't permit rushed causal correlations or ‘therapeutic aggressiveness'.Cerebrovasc Dis 2015;39:162-169
Source: Cerebrovascular Diseases - February 26, 2015 Category: Neurology Source Type: research

Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
Publication date: Available online 28 September 2018Source: The Lancet NeurologyAuthor(s): Scott E Kasner, Balakumar Swaminathan, Pablo Lavados, Mukul Sharma, Keith Muir, Roland Veltkamp, Sebastian F Ameriso, Matthias Endres, Helmi Lutsep, Steven R Messé, J David Spence, Krassen Nedeltechev, Kanjana Perera, Gustavo Santo, Veronica Olavarria, Arne Lindgren, Shrikant Bangdiwala, Ashkan Shoamanesh, Scott D Berkowitz, Hardi MundlSummaryBackgroundPatent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurren...
Source: The Lancet Neurology - October 5, 2018 Category: Neurology Source Type: research

Aura and Stroke: relationship and what we have learnt from preclinical models
ConclusionPreclinical models suggest a key role for enhanced SD susceptibility and microembolization to explain both the occurrence of migraine attacks and the increased stroke risk in migraineurs. Therapeutic targeting of SD and microembolic events, or potential causes thereof, will be promising for treatment of aura and may also prevent ischemic infarction in vulnerable brains.
Source: The Journal of Headache and Pain - May 28, 2019 Category: Neurology Source Type: research

Migraine and Ischemic Stroke in Women. A Narrative Review.
CONCLUSION: The commonality of factors associated with MWA and with MWA-associated stroke suggest that persons with secondary, ischemia-induced aura may be at elevated risk of stroke. Although further research is needed, we recommend consideration of a diagnostic evaluation of MWA that mirrors the evaluation of transient ischemic attack, given that prophylactic treatment targeting the ischemic origin of secondary aura may prevent migraine as well as stroke. PMID: 32246455 [PubMed - as supplied by publisher]
Source: Headache - April 3, 2020 Category: Neurology Authors: Tietjen GE, Maly EF Tags: Headache Source Type: research

Who Should Rather Undergo Transesophageal Echocardiography to Determine Stroke Etiology: Young or Elderly Stroke Patients?
Conclusions: TEE was highly valuable for determining stroke etiology and influenced individual secondary prevention based on available treatment guidelines and expert opinion in most cases. In young patients the impact of TEE was limited to the detection of septal anomalies. By contrast, in older patients TEE detected high numbers of complex aortic atheroma and potential indicators of paroxysmal atrial fibrillation.
Source: Frontiers in Neurology - December 18, 2020 Category: Neurology Source Type: research