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Condition: Pain

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Total 374 results found since Jan 2013.

CAV-1 Overexpression Exacerbates the Manifestation in EPAC-1-Induced Chronic Postsurgical Pain in Rats
CONCLUSION: CAV-1 mediates the functional coupling of microglia, astrocytes, and neurons, and thus EPAC-1/CAV-1 plays an important role in CPSP exacerbation.PMID:35958678 | PMC:PMC9357801 | DOI:10.1155/2022/8566840
Source: Pain Research and Management - August 12, 2022 Category: Anesthesiology Authors: Qian Hua Shiren Shen Yibin Qin Su Cao Source Type: research

P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling
CONCLUSION: These findings suggest that targeting the microglial P2X7R activated NLRP3/IL-1beta signaling pathway could serve as a potential strategy for BCP treatment.PMID:36375190
Source: Pain Physician - November 14, 2022 Category: Anesthesiology Authors: Ping Wu Xiaoqi Wu Guohua Zhou Yin Wang Xiaojun Liu Run Lv YanSong Liu Qingping Wen Source Type: research

Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain
CONCLUSIONS: These findings suggest that reduction of SIRT1-mediated epigenetic upregulation of Nav1.7 in the DRG contributes to the development of oxaliplatin-induced neuropathic pain in rats. The intrathecal drug delivery treatment of activating SIRT1 might be a novel therapeutic option for oxaliplatin-induced neuropathic pain.PMID:37192244
Source: Pain Physician - May 16, 2023 Category: Anesthesiology Authors: Ling-Jun Xu Jing Wang Gui-Dan Li Kai-Feng Shen Xing-Hui He Wei Wu Cui-Cui Liu Source Type: research

POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment
Neurochem Res. 2023 Aug 18. doi: 10.1007/s11064-023-04011-w. Online ahead of print.ABSTRACTEvidence demonstrates that DNA methylation is associated with the occurrence and development of various neurological diseases. However, the potential target genes undergoing DNA methylation, as well as their involvement in the chemotherapy drug oxaliplatin-induced neuropathic pain, are still unclear. Here, Lrfn4, which showed hypermethylation in the promoter regions, was screened from the SRA methylation database (PRJNA587622) following oxaliplatin treatment. MeDIP and qPCR assays identified that oxaliplatin treatment increased the m...
Source: Neurochemical Research - August 17, 2023 Category: Neuroscience Authors: Yan-Hui Gu Jing Wang Wei-Cheng Lu Yong Cheng Rong Tao Shi-Jia Zhang Ting Xu Ke-Wei Zhai Su-Xia Luo Wen-Jun Xin Source Type: research

Modulation of A-type K(+) channels by the short-chain cobrotoxin through the protein kinase C-delta isoform decreases membrane excitability in dorsal root ganglion neurons.
In this study, we identified the functional role of cobrotoxin, the short-chain α-neurotoxin isolated from Naja atra venom, which acts in the regulation of the transient A-type K(+) currents (I(A)) and membrane excitability in dorsal root ganglion (DRG) neurons via the activation of the muscarinic M3 receptor (M3R). Our results showed that cobrotoxin increased I(A) in a concentration-dependent manner, whereas the sustained delayed rectifier K(+) currents (I(DR)) were not affected. Cobrotoxin did not affect the activation of I(A) markedly, however, it shifted the inactivation curve significantly in the depolarizing directi...
Source: Biochemical Pharmacology - February 19, 2013 Category: Drugs & Pharmacology Authors: Guo Q, Jiang YJ, Jin H, Jiang XH, Gu B, Zhang YM, Wang JG, Qin ZH, Tao J Tags: Biochem Pharmacol Source Type: research

Expression and Functional Role of Metallothioneins I and II in the Spinal Cord in Inflammatory and Neuropathic Pain Models.
In this study, the expression and functional role of metallothioneins I and II (MT-I/II) were evaluated in the spinal cord in rat models of inflammatory and neuropathic pain. Complete Freund's adjuvant (CFA) injection into the hindpaw induced an increase in MT-I/II protein expression in bilateral dorsal and ventral horns throughout the spinal cord, while chronic constriction injury (CCI) of the sciatic nerve induced an increase in MT-I/II expression in the ipsilateral dorsal and ventral horns of the lower lumbar spinal cord. Increased MT-I/II immunoreactivity was predominantly localized to vascular endothelial cells. CFA i...
Source: Brain Research - May 30, 2013 Category: Neurology Authors: Kwon A, Jeon SM, Hwang SH, Kim JH, Cho HJ Tags: Brain Res Source Type: research

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signaling pathways
Conclusions: These findings suggest that fHAs may have the potential to mediate IVD degeneration and discogenic back pain through activation of the TLR2 signaling pathway in resident IVD cells.
Source: BioMed Central - August 22, 2013 Category: Journals (General) Authors: Lilian QueroMarina KlawitterAnja SchmausMelanie RothleyJonathan SleemanAndré N TiadenJuergen KlasenNorbert BoosMichael O HottigerKarin WuertzPeter J Richards Source Type: research

Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain
Summary: Modified expression and function of the adhesion molecule neuroligin 2 are involved in the excitation/inhibition imbalance leading to the dorsal horn network’s hyperexcitability in neuropathic rats.Abstract: In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and inhibitory synapses, respectively. In the dorsal horn of SNL rats, NL2 was overexpressed whe...
Source: Pain - July 29, 2013 Category: Anesthesiology Authors: Tiphaine Dolique, Alexandre Favereaux, Olivier Roca-Lapirot, Virginie Roques, Claire Léger, Marc Landry, Frédéric Nagy Tags: Research papers Source Type: research

Valproate Prevents Dysregulation of Spinal Glutamate and Reduces the Development of Hypersensitivity in Rats After Peripheral Nerve Injury
This study demonstrates that valproate prevents the downregulation of glutamate transporters in the spinal cord, which contributes in part to the development of chronic pain after nerve injury. Given clinical availability and established safety profiles, perioperative use of valproate should be tested to prevent chronic pain after surgery.
Source: The Journal of Pain - September 9, 2013 Category: Materials Science Authors: Masaru Yoshizumi, James C. Eisenach, Ken-ichiro Hayashida Tags: Original Reports Source Type: research

Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain
Conclusions: These results show that mechanical stress, IL-1beta and extracellular visfatin/NAMPT, all stimulated the expression and release of NGF by chondrocytes and thus suggest that the overexpression of visfatin/NAMPT and IL-1beta in OA joint and the increased mechanical loading of cartilage may mediate OA pain via the stimulation of NGF expression and release by chondrocytes.
Source: Arthritis Research and Therapy - January 20, 2014 Category: Rheumatology Authors: Emilie PecchiSabrina PriamMarjolaine GossetAudrey PigenetLaure SudreMarie-Charlotte LaiguillonFrancis BerenbaumXavier Houard Source Type: research

Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.
Abstract Bone cancer pain is a major clinical problem and remains difficult to treat. ATP-sensitive potassium (KATP) channels may be involved in regulating nociceptive transmission at the spinal cord level. We determined the role of spinal KATP channels in the control of mechanical hypersensitivity in a rat model of bone cancer pain. The rat model of bone cancer pain was induced by implanting rat mammary gland carcinoma cells (Walker256) into the tibias. KATP modulators (pinacidil and glibenclamide) or the specific Kir6.2-siRNA were injected via an intrathecal catheter. The mechanical withdrawal threshold of rats ...
Source: Brain Research - January 27, 2014 Category: Neurology Authors: Xia H, Zhang D, Yang S, Wang Y, Xu L, Wu J, Ren J, Yao W, Fan L, Zhang C, Tian Y, Pan HL, Wang X Tags: Brain Res Source Type: research

Menin regulates spinal glutamate-GABA balance through GAD65 contributing to neuropathic pain.
CONCLUSION: Our findings provide mechanistic insight into the contribution of the upregulated spinal menin to peripheral nerve injury induced neuropathic hypersensitivity by regulating glutamate-GABA balance through deactivating GAD65. PMID: 24905306 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - February 1, 2014 Category: Drugs & Pharmacology Authors: Shen X, Liu Y, Xu S, Zhao Q, Wu H, Guo X, Shen R, Wang F Tags: Pharmacol Rep Source Type: research