Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signaling pathways

Conclusions:
These findings suggest that fHAs may have the potential to mediate IVD degeneration and discogenic back pain through activation of the TLR2 signaling pathway in resident IVD cells.

Source: BioMed Central - August 22, 2013 Category: Journals (General) Authors: Lilian QueroMarina KlawitterAnja SchmausMelanie RothleyJonathan SleemanAndré N TiadenJuergen KlasenNorbert BoosMichael O HottigerKarin WuertzPeter J Richards Source Type: research