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Subtotal Gastrectomy With Billroth II Anastomosis Is Associated With a Low Risk of Ischemic Stroke in Peptic Ulcer Disease Patients: A Nationwide Population-Based Study
Abstract: Duodenal diversion can ameliorate lipid and glucose metabolism. We assessed the risk of stroke after subtotal gastrectomy with Billroth II anastomosis (SGBIIA) in peptic ulcer disease (PUD). We identified 6425 patients who received SGBIIA for PUD between 1998 and 2010 from the Taiwan National Health Insurance Research Database as the study cohort; we frequency-matched them with 25,602 randomly selected controls from the PUD population who did not receive SGBIIA according to age, sex, index year, and comorbidities including hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, congestive heart...
Source: Medicine - April 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The Association Between Peptic Ulcer Disease and Ischemic Stroke: A Population-Based Longitudinal Study
Abstract: Stroke is a common cause of death worldwide, but about 30% of ischemic stroke (IS) patients have no identifiable contributing risk factors. Because peptic ulcer disease (PUD) and vascular events share some common risk factors, we conducted a population-based study to evaluate the association between PUD and IS. We followed up a representative sample of 1 million residents of Taiwan using the National Health Insurance Research Database from 1997 to 2011. We defined patients who received medications for PUD and had related diagnosis codes as the PUD group, and a reference group matched by age and sex was sampled f...
Source: Medicine - May 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Agent Orange exposure and disease prevalence in Korean Vietnam veterans: The Korean veterans health study.
In conclusion, Agent Orange exposure increased the prevalence of endocrine disorders, especially in the thyroid and pituitary gland; various neurologic diseases; COPD; and liver cirrhosis. Overall, this study suggests that Agent Orange/2,4-D/TCDD exposure several decades earlier may increase morbidity from various diseases, some of which have rarely been explored in previous epidemiologic studies. PMID: 24906069 [PubMed - as supplied by publisher]
Source: Environmental Research - June 3, 2014 Category: Environmental Health Authors: Yi SW, Hong JS, Ohrr H, Yi JJ Tags: Environ Res Source Type: research

Prescription patterns of traditional Chinese medicine for peptic ulcer disease in Taiwan: A nationwide population-based study
Conclusions Our study identified the core prescription patterns of TCM for patients with peptic ulcer disease in Taiwan. Further basic and clinical studies are necessary to elucidate the efficacy and mechanisms. Graphical abstract
Source: Journal of Ethnopharmacology - November 18, 2015 Category: Drugs & Pharmacology Source Type: research

The association between participation in a pay-for-performance program and macrovascular complications in patients with type 2 diabetes in Taiwan: A nationwide population-based cohort study
Conclusions Compared with patients not enrolled in the P4P program, P4P patients had lower risk of developing serious vascular complications. Our empirical findings provide evidence for the potential long-term benefit of P4P programs in reducing risks of macrovascular complications.
Source: Preventive Medicine - January 11, 2016 Category: Global & Universal Source Type: research

An estimation of the incidence of tuberous sclerosis complex by a nationwide retrospective cohort study from 1997 to 2010
ConclusionsThis is the first large scale and longitudinal incidence study of TSC. This study provides compelling evidences in humans that TSC mutations are associated with decreased risk of peptic ulcers.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - January 23, 2016 Category: Dermatology Authors: C.‐H. Hong, H.‐P. Tu, J.‐R. Lin, C.‐H. Lee Tags: Original Article Source Type: research

An estimation of the incidence of tuberous sclerosis complex by a nationwide retrospective cohort study from 1997 to 2010.
CONCLUSIONS: This is the first large scale and longitudinal incidence study of TSC. This study provides compelling evidences in humans that TSC mutations are associated with decreased risk of peptic ulcers. This article is protected by copyright. All rights reserved. PMID: 26800857 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 23, 2016 Category: Dermatology Authors: Hong CH, Tu HP, Lin JR, Lee CH Tags: Br J Dermatol Source Type: research

Association Between Subtotal Gastrectomy with Billroth II Anastomosis and Coronary Heart Disease
ConclusionsWe found SGBIIA is associated with a reduced risk of CHD for PUD patients.
Source: Obesity Surgery - January 10, 2017 Category: Surgery Source Type: research

The risk of lower gastrointestinal bleeding in low ‐dose aspirin users
ConclusionsThe risk of LGIB was higher in low‐dose aspirin users than in aspirin nonusers in this nationwide cohort. Low‐dose aspirin, NSAIDs, steroids, SSRIs, PPIs and H2RAs were independent risk factors for LGIB.
Source: Alimentary Pharmacology and Therapeutics - April 27, 2017 Category: Drugs & Pharmacology Authors: W. ‐C. Chen, K.‐H. Lin, Y.‐T. Huang, T.‐J. Tsai, W.‐C. Sun, S.‐K. Chuah, D.‐C. Wu, P.‐I. Hsu Tags: Original Article Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news