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Specialty: Neuroscience
Condition: Hypertension

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Total 232 results found since Jan 2013.

Exacerbation of blood-brain barrier breakdown, edema formation, nitric oxide synthase upregulation and brain pathology after heat stroke in diabetic and hypertensive rats. Potential neuroprotection with cerebrolysin treatment
Publication date: Available online 18 July 2019Source: International Review of NeurobiologyAuthor(s): Dafin Fior Muresanu, Aruna Sharma, Ranjana Patnaik, Preeti K. Menon, Herbert Mössler, Hari Shanker SharmaAbstractThere is a growing trend of hypertension among military and civilian populations due to lifetime stressful situations. If hypertension is uncontrolled it leads to development of diabetes and serious neurological complications. Most of the World populations live in temperate zone across the World. Thus, a possibility exists that these hypertensive and diabetic people may have external heat as potential risk fact...
Source: International Review of Neurobiology - July 19, 2019 Category: Neuroscience Source Type: research

Carotid artery plaque detected on ultrasound is associated with impaired cognitive state in the elderly: A population-based study in Wakiso district, Uganda
This study set out to determine the prevalence of abnormal carotid ultrasound findings and their association with cognitive function among the adults ≥60 years in Wakiso district, Uganda in 2018. A total of 210 participants were included. Carotid artery stenosis, presence of plaque, stenosis and intima-media thickness were assessed by ultrasound. Cognitive status was assessed using a Mini Mental State Exam (MMSE) test. The prevalence of plaque was 21.4%. Variables which included; presence of plaque, age, education, gender, marital status, whether participant stayed alone or with someone else, care for self, occupation ...
Source: Journal of Clinical Neuroscience - July 12, 2019 Category: Neuroscience Source Type: research

Mechanical thrombectomy for recurrent large vessel occlusion
Publication date: Available online 18 May 2019Source: Journal of Clinical NeuroscienceAuthor(s): P. Bhogal, M. AlMatter, V. Hellstern, M. Aguilar Pérez, O. Ganslandt, H. Bäzner, H. HenkesAbstractAlthough mechanical thrombectomy (MT) has been shown in numerous trials to be a successful treatment option for patients with large vessel occlusion (LVO), there is limited information on the safety and effectiveness of the technique in cases of recurrent LVO. To this end, we performed a retrospective review of our prospectively maintained database to identify all patients that had undergone more than one MT procedure January 200...
Source: Journal of Clinical Neuroscience - May 19, 2019 Category: Neuroscience Source Type: research

A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
AbstractThe fine balance between the secretion, composition, volume and turnover of cerebrospinal fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance can be disrupted. A significant disruption to the normal CSF circulation can be life threatening, leading to increased intracranial pressure (ICP), and is implicated in hydrocephalus, idiopathic intracranial hypertension, brain trauma, brain tumours and stroke. Yet, the exact cellular, molecular and physiological mechanisms that contribute to altered hydrodynamic pathways in these diseases are poorly defined or hotly debated. The tra...
Source: Fluids and Barriers of the CNS - April 9, 2019 Category: Neuroscience Source Type: research

Correlation between pre-admission blood pressure and outcome in a large telestroke cohort
ConclusionsThis study displays better clinical outcomes at latest follow-up when compared to current international TS studies. SBP during transportation to the hub hospital did not prove to be a useful prognostic metric. However, future studies should address the limitations of this study to confirm these findings.
Source: Journal of Clinical Neuroscience - January 17, 2019 Category: Neuroscience Source Type: research

Sex differences in risk factors for vascular contributions to cognitive impairment & dementia
Publication date: Available online 22 November 2018Source: Neurochemistry InternationalAuthor(s): O.J. Gannon, L.S. Robison, A.J. Custozzo, K.L. ZuloagaAbstractVascular contributions to cognitive impairment and dementia (VCID) is the second most common cause of dementia. While males overall appear to be at a slightly higher risk for VCID throughout most of the lifespan (up to age 85), some risk factors for VCID more adversely affect women. These include female-specific risk factors associated with pregnancy related disorders (e.g. preeclampsia), menopause, and poorly timed hormone replacement. Further, presence of certain ...
Source: Neurochemistry International - November 23, 2018 Category: Neuroscience Source Type: research

Impact of risk factors for recurrence after the first ischemic stroke in adults: A systematic review and meta-analysis
Publication date: Available online 16 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Shengbang Zheng, Baodong YaoAbstractRisk factors for first-ever stroke have been studied extensively, while those for recurrent stroke are not accurately understood. To provide the adequate secondary prevention for the patients, it is necessary to reveal the risk factors that dominate recurrent stroke. Multiple databases were adopted to search for the relevant studies and full-text articles involving in the risk factors for stroke recurrence were reviewed. Meta-analyses were performed with Review Manager 5.0 to estimate the...
Source: Journal of Clinical Neuroscience - October 17, 2018 Category: Neuroscience Source Type: research

Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson’s disease
ConclusionsThis study demonstrates an association between SVD and motor impairment, and between vascular risk factors, particularly hypertension, and dementia in PD and highlights the need to manage vascular co-morbidities in PD patients.
Source: Journal of Clinical Neuroscience - October 14, 2018 Category: Neuroscience Source Type: research

Blood –brain and blood–cerebrospinal fluid barrier permeability in spontaneously hypertensive rats
ConclusionIn conclusion, we found no evidence for blood –brain barrier or blood–cerebrospinal fluid barrier leakage to a small solute, fluorescein, in rats with established hypertension.
Source: Fluids and Barriers of the CNS - September 24, 2018 Category: Neuroscience Source Type: research

Associations between low circulatory low-density lipoprotein cholesterol level and brain health in non-stroke non-demented subjects
In conclusion, the role of circulatory LDL-C level and its interactive effect with hypertension on brain health are firstly demonstrated. A low circulatory LDL-C level was associated with reduced regional brain GMVs in hypertensive but not normotensive subjects. In addition, there seems a combined detrimental-effect of low circulatory LDL-C levels with hypertension on posterior cingulate GMV, WMH, and verbal memory.
Source: NeuroImage - July 25, 2018 Category: Neuroscience Source Type: research

Impact of microRNAs on ischemic stroke: From pre- to post-disease
Publication date: April–May 2018Source: Progress in Neurobiology, Volumes 163–164Author(s): Guangwen Li, Kahlilia C. Morris-Blanco, Mary S. Lopez, Tuo Yang, Haiping Zhao, Raghu Vemuganti, Yumin LuoAbstractStroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttransc...
Source: Progress in Neurobiology - July 10, 2018 Category: Neuroscience Source Type: research

Serum 25-hydroxyvitamin D deficiency predicts poor outcome among acute ischemic stroke patients without hypertension
Publication date: Available online 3 May 2018Source: Neurochemistry InternationalAuthor(s): Bingjun Zhang, Yuge Wang, Yi Zhong, Siyuan Liao, Zhengqi LuAbstract25-Hydroxyvitamin D (25(OH)D) deficiency is a frequent condition in patients who suffer acute ischemic stroke (AIS), and several studies suggested that it may be associated with a poorer prognosis. Whether this association is affected by hypertension is unclear. Our aim was to investigate the association between 25(OH)D levels and both clinical severity and outcome after 3 months in AIS patients stratified by the history of hypertension. Consecutive first-ever AIS pa...
Source: Neurochemistry International - July 10, 2018 Category: Neuroscience Source Type: research

Impact of microRNAs on ischemic stroke: From pre- to post-disease
Publication date: April–May 2018Source: Progress in Neurobiology, Volumes 163–164Author(s): Guangwen Li, Kahlilia C. Morris-Blanco, Mary S. Lopez, Tuo Yang, Haiping Zhao, Raghu Vemuganti, Yumin LuoAbstractStroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttransc...
Source: Progress in Neurobiology - July 5, 2018 Category: Neuroscience Source Type: research