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Ceruloplasmin dysfunction: a key factor in the pathophysiology of atrial fibrillation?
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - November 5, 2013 Category: Internal Medicine Authors: Jamie Y Jeremy, Nilima Shukla Tags: Editorial Comment Source Type: research

Saturated fat link with heart disease questioned
This article is one doctor's opinion based on his own knowledge, research and experience. However, it is fair to say there is an ongoing debate about how far cholesterol is a risk factor for heart disease, especially in people who are otherwise healthy. There is also a similar debate about the use of statins in people who have no evidence of cardiovascular disease. This is alongside ongoing research into the components of LDL and the different types of lipoproteins known to increase risk the most. None of this relevant new evidence is covered by the news reporting.   What should you eat? There is no need to change curren...
Source: NHS News Feed - October 23, 2013 Category: Consumer Health News Tags: Heart/lungs Food/diet QA articles Source Type: news

Hypertension-related diseases as a common cause of hospital mortality in Tanzania: a 3-year prospective study
Conclusion: NCDs account for half of all deaths, admissions and hospital days at our Tanzanian hospital and hypertension-related diseases were the most common NCD. Hypertension accounted for 34% of NCD deaths and 15% of all deaths. Hypertension was the second most common cause of death overall and the leading cause of death in patients more than 50 years old. More than half of hypertension-related deaths occurred before retirement age. These findings have important implications for public health and medical education in sub-Saharan Africa, wherein hypertension and related diseases have not traditionally been given a high priority.
Source: Journal of Hypertension - August 16, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Recent advances in the epidemiology, outcome, and prevention of myocardial infarction and stroke in sub-Saharan Africa
The early part of the new millennium witnessed reports of a growing burden of cardiovascular disease in Sub-Saharan Africa (SSA). However the contribution of ischemic heart disease and stroke to this increasing burden relative to that caused by hypertensive heart disease, cardiomyopathy and rheumatic heart disease was not clear. Over the last decade, data from the continent has begun to clarify this issue and suggests three main points. The burden of ischemic heart disease relative to other causes of heart disease remains low particularly in the black Africans majority. Stroke caused predominantly by hypertension is now a ...
Source: Heart - August 2, 2013 Category: Cardiology Authors: Ntsekhe, M., Damasceno, A. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Global burden of cardiovascular disease Source Type: research

If you could propose one idea to help improve health care delivery in the United States, what would it be?
Thumbnail: Tags: conversationsphrma conversationslarry hausnermyrl weinbergchris hansennancy brownContributors: 11621161115911631173Contributions: Read Larry Hausner's bio Despite the rapid development of innovative technologies in the health care field, we have yet to discover a panacea that will easily transform our health care system into one that provides high-quality and cost-effective care.  What we have discovered and come to agree on over the last decade is that our sick care system must be reconfigured to a health care system that emphasizes wellness and prevention.  For that reason, I offer ...
Source: PHRMA - June 24, 2013 Category: Pharmaceuticals Authors: rlowe Source Type: news

MicroRNAs In Arterial Hypertension.
Abstract Arterial hypertension is an epidemic currently affecting almost a billion people worldwide. The consequences from high blood pressure vary, from peripheral arterial disease and chronic kidney failure to acute myocardial infarction and stroke. MicroRNAs (miRNAs) are small non-coding RNA molecules comprised of 22-26 nucleotides and provide post-transcriptional protein expression regulation. The many biological processes in which they are implicated, such as cell proliferation, apoptosis, metabolism, cell differentiation and morphogenesis confirms the functional significance of miRNAs. It has been found that...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Synetos A, Toutouzas K, Stathogiannis K, Latsios G, Tsiamis E, Tousoulis D, Stefanadis C Tags: Curr Top Med Chem Source Type: research

The “know your numbers” program in Atahualpa — A pilot study aimed to reduce cardiovascular diseases and stroke burden in rural communities of developing countries
The burden of cardiovascular diseases and stroke is steadily increasing in many low- and middle-income countries, to the point that these conditions have been considered as the new epidemics of the developing world . The World Health Organization has set a global goal of reducing deaths from non-communicable diseases (including stroke and ischemic heart disease) by 25% by 2025 . It seems that people living in rural communities are most vulnerable to these “new epidemics”. There, a process of epidemiologic transition is aggravated by poor access to medical care and by income issues that preclude people to afford the cos...
Source: International Journal of Cardiology - May 6, 2013 Category: Cardiology Authors: Oscar H. Del Brutto, Martha Montalván, Daniel Tettamanti, Ernesto Peñaherrera, Rocío Santibáñez, Freddy Pow-Chon-Long, Victor J. Del Brutto Tags: Letters to the Editor Source Type: research

Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease.
Abstract There is a global epidemic of obesity, metabolic syndrome, and diabetes mellitus. Insulin resistance (IR) is etiologic for both metabolic syndrome and diabetes mellitus. IR induces a broad range of toxic systemic effects, including dyslipidemia, hypertension, hyperglycemia, increased production of advanced glycosylation end products, increased inflammatory tone, as well as a prothrombotic and pro-oxidative state. Patients with IR are highly vulnerable to the development of accelerated atherosclerosis as well its clinical sequelae, including coronary artery disease and myocardial infarction, carotid artery...
Source: Current Vascular Pharmacology - April 25, 2013 Category: Drugs & Pharmacology Authors: Toth PP Tags: Curr Vasc Pharmacol Source Type: research

Pharmacotherapy of obesity: clinical treatments and considerations.
Abstract Obesity is a world-wide epidemic associated with significant morbidity and mortality which costs billions of dollars per year. The associated related conditions are many and include heart disease, stroke, type II diabetes mellitus, sleep apnea and certain types of cancer. Given that it is a multifactorial problem, the treatments must also address the numerous causes associated with the development of obesity. The neurohormonal regulation of feeding and energy is a complex system often necessitating modification through more than 1 pathway to achieve weight loss. Therefore, in addition to lifestyle changes...
Source: The American Journal of the Medical Sciences - April 1, 2013 Category: Journals (General) Authors: Holes-Lewis KA, Malcolm R, O'Neil PM Tags: Am J Med Sci Source Type: research

Republished: Mainstreaming HIV services for men who have sex with men: the role of general practitioners
Mainstreaming HIV services for men who have sex with men: The role of general practitioners General practitioners (GPs) and other primary care doctors around the world have a strong potential for providing quality HIV prevention, testing and treatment for men who have sex with men, as advocated by the recent WHO guideline.1 As the HIV epidemic becomes more focused on chronic disease care in many parts of the world, a number of primary care issues come to the forefront of clinical HIV service delivery. GPs have advantages in providing HIV services because of their position as trusted, community-based, long-term advocates fo...
Source: Postgraduate Medical Journal - March 12, 2013 Category: Journals (General) Authors: Wong, W. C. W., Kidd, M. R., Tucker, J. D. Tags: Liver disease, Sexual transmitted infections (viral), General practice / family medicine, Immunology (including allergy), Drugs: infectious diseases, HIV/AIDS, Stroke, Hypertension, Communication, Ethics, Legal and forensic medicine Republished editoria Source Type: research

Association of obesity with socio-economic factors and obesity-related chronic diseases in rural southwest China
Conclusions: In order to reduce the obesity epidemic in rural southwest China, effective interventions must address socio-economic factors. Reducing obesity has a profound impact on the reduction of morbidity associated with cardiovascular diseases and diabetes.
Source: Public Health - February 22, 2013 Category: Global & Universal Authors: L. Cai, J. He, Y. Song, K. Zhao, W. Cui Tags: Original Research Source Type: research

Acute Stroke in Young Women Taking Phentermine (P01.249)
CONCLUSIONS: We present here two patients with mild underlying cerebrovascular risk factors who presented with acute stroke after taking diet pills containing phentermine. The public should be aware of the possible association between stroke and phentermine. More long-term outcomes research is necessary to understand the safety of phentermine-containing diet pills. Patients with cerebrovascular risk factors should be cautious about using Phentermine containing diet pills.Disclosure: Dr. Smit has nothing to disclose. Dr. Cutting has received personal compensation for activities with F1000. Dr. Conners has nothing to disclos...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Smit, L., Cutting, S., Conners, J., Lee, V., Song, S. Tags: P01 Cerebrovascular Disease I Source Type: research

Population-based study of cardiovascular health in Atahualpa, a rural village of coastal Ecuador
The American Heart Association (AHA) recently defined the metrics needed to categorize cardiovascular health (CVH), to implement strategies directed to reduce vascular deaths among US populations . The same could be applied to developing countries, where stroke and cardiovascular diseases will be the next health epidemics due to changes in lifestyle and increased life expectancy . Indeed, the rate of vascular deaths in Latin America is higher than in the developed world; this excess mortality fraction could be related to modifiable factors, including: inadequate access to medical care, increasing obesity and diabetes melli...
Source: International Journal of Cardiology - February 13, 2013 Category: Cardiology Authors: Oscar H. Del Brutto, Milton Santamaría, Elio Ochoa, Ernesto Peñaherrera, Rocío Santibáñez, Freddy Pow-Chon-Long, Mauricio Zambrano, Victor J. Del Brutto Tags: Letters to the Editor Source Type: research

Influence of dietary patterns on the risk of acute myocardial infarction in China population: the INTERHEART China study.
CONCLUSIONS: Unhealthy dietary intake can increase the AMI risk. Improving intake of vegetables, fruits and tofu have the potential to partially prevent the rising epidemic of cardiovascular disease in China. PMID: 23422108 [PubMed - in process]
Source: Chinese Medical Journal - February 1, 2013 Category: Journals (General) Authors: Guo J, Li W, Wang Y, Chen T, Teo K, Liu LS, Yusuf S, INTERHEART China study investigators Tags: Chin Med J (Engl) Source Type: research

Drug treatments to restore vascular function and diabesity.
Abstract Over the last decades, an escalating rate of type 2 diabetes has paralleled an epidemic rise in the prevalence of obesity. Both diabetes and obesity confer an increased risk of cardiovascular comorbidities, including hypertension, coronary artery disease and stroke. Vascular dysfunction, represented by impaired endothelial release of vasodilator substances or defective smooth muscle vasodilator reactivity, is the early stage of the process leading to atherosclerosis and a common finding in patients with diabesity. It is understandable, therefore, that effective treatments for diabesity should restore vasc...
Source: Annales Pharmaceutiques Francaises - January 1, 2013 Category: Drugs & Pharmacology Authors: Cardillo C Tags: Ann Pharm Fr Source Type: research

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