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Condition: Hemorrhagic Stroke
Therapy: Statin Therapy

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Total 361 results found since Jan 2013.

Number of Cerebral Microbleeds and Risk of Intracerebral Hemorrhage After Intravenous Thrombolysis Clinical Sciences
Conclusions— Our findings indicate a higher risk of sICH and PH after intravenous thrombolysis when multiple CMBs are present, with a graded relationship to increasing baseline CMB number.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Dannenberg, S., Scheitz, J. F., Rozanski, M., Erdur, H., Brunecker, P., Werring, D. J., Fiebach, J. B., Nolte, C. H. Tags: Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis Clinical Sciences Source Type: research

Statin use and risk of haemorrhagic stroke in a community-based cohort of postmenopausal women: an observational study from the Women's Health Initiative
Conclusions This retrospective analysis did not show an association between statin use and HS risk among older women. HS risk was higher among women taking statins with antiplatelet agents. These findings warrant further investigation, given potential implications for clinical decision-making.
Source: BMJ Open - February 25, 2015 Category: Journals (General) Authors: Salmoirago-Blotcher, E., Hovey, K. M., Andrews, C. A., Robinson, J. G., Johnson, K. C., Wassertheil-Smoller, S., Crawford, S., Qi, L., Martin, L. W., Ockene, J., Manson, J. E., Nabel, E., Rossouw, J., Ludlam, S., McGowan, J., Ford, L., Geller, N., Prentic Tags: Open access, Cardiovascular medicine, Epidemiology Research Source Type: research

Statins and Intracerebral Hemorrhage: Potential Mechanisms
In a recent publication, Tapia Pérez et al1 have argued, based on some of the previous meta-analyses, that the risk for statin-induced intracerebral hemorrhage (ICH) has been refuted. However, this is a premature and somewhat misleading conclusion, as whether high-dose statin therapy can elicit ICH remains to be a subject of contention among researchers and clinicians.2 In fact, according to the most recent guidelines by the American Stroke Association for the management of ICH, the question of whether statin therapy should be continued in patients remains elusive.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2015 Category: Neurology Authors: Shahram Eisa-Beygi, Suzan El-Rass Tags: Letter to the Editor Source Type: research

Response to "Association between statin use and ischemic stroke or major hemorrhage in patients taking dabigatran for atrial fibrillation".
PMID: 28246232 [PubMed - in process]
Source: cmaj - February 26, 2017 Category: Journals (General) Authors: Antoniou T, Mamdani M, Juurlink D Tags: CMAJ Source Type: research

Association between statin use and ischemic stroke or major hemorrhage in patients taking dabigatran for atrial fibrillation.
PMID: 28246231 [PubMed - in process]
Source: cmaj - February 26, 2017 Category: Journals (General) Authors: Haertter S, Huang F, Franca LR Tags: CMAJ Source Type: research

Statin Treatment in Patients With Intracerebral Hemorrhage Comments and Opinions
Source: Stroke - December 22, 2017 Category: Neurology Authors: Matthias Endres, Christian H. Nolte, Jan F. Scheitz Tags: Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Comments and Opinions Source Type: research

Low LDL-C and risk of hemorrhagic stroke in Chinese adults
It is well-established that higher LDL and total cholesterol are associated with increased risk of atherosclerotic cardiovascular disease (ASCVD), that is, coronary heart disease (CHD) and ischemic stroke events, and that cholesterol-lowering by statins and other therapies reduce ASCVD risk. However, the picture is less clear for the 10% to 20% of strokes that are hemorrhagic rather than ischemic. A meta-analysis of observational studies shows that lower levels of LDL-C and total cholesterol are associated with higher risk of hemorrhagic strokes (HS), and with intracranial hemorrhage (ICH), a subset of HS.
Source: Journal of Clinical Lipidology - September 1, 2018 Category: Lipidology Authors: Rachel H. Mackey Tags: Editorial Source Type: research

Statin, cholesterol, and sICH after acute ischemic stroke: systematic review and meta-analysis
ConclusionPrior/new statin use and lower cholesterol level are not risk factors for sICH and overall ICH in AIS patients, whether or not the patient has received recanalization therapy. New statin use is likely associated with decreased sICH.
Source: Neurological Sciences - July 1, 2019 Category: Neurology Source Type: research

Intracranial hemorrhage in large vessel occlusion patients receiving endovascular thrombectomy with or without intravenous alteplase: a secondary analysis of the DIRECT-MT trial
Conclusions Our data showed that in the DIRECT-MT trial, alteplase did not increase overall ICH for large vessel occlusion patients treated with thrombectomy, but it increased the parenchymal hematoma rate.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Hu, X., Zhou, Y., Ospel, J., Yao, F., Liu, Y., Wang, H., Li, B., Hui, P., Yang, P., Zhang, Y., Zhang, L., Li, Z., Xing, P., Shi, H., Han, H., Wang, S., Fang, Q., Liu, J., for the Direct-MT investigators Tags: Open access, Ischemic stroke Source Type: research

Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis
Conclusion: We found a statistically insignificant tendency for the ultrasound-measured length of sICAS<70% to be longer than that of sICAS≥70%. Moreover, the ultrasound-measured length of sICAS<90% was significantly longer than that of sICAS 90%. Among patients with sICAS≥70%, the degree and length of stenosis were inversely correlated. Larger studies are needed before a clinical implication can be drawn from these results. Introduction Internal carotid artery stenosis (ICAS) causes around one-fifth of ischemic cerebrovascular stroke and has the highest risk of early stroke recurrence...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Cerebrovascular Disease and Statins
Front Cardiovasc Med. 2021 Dec 2;8:778740. doi: 10.3389/fcvm.2021.778740. eCollection 2021.ABSTRACTElevated low-density lipoprotein-cholesterol (LDL-C) is a causal factor for the development of atherosclerotic cardiovascular disease (ASCVD); accordingly, LDL-C lowering is associated with a decreased risk of progression of atherosclerotic plaques and development of complications. Currently, statins play a central role in any ASCVD management and prevention strategies, in relation to their lipid-lowering action and potentially to pleiotropic effects. After coronary artery disease, stroke is the most frequent cause of ASCVD m...
Source: Atherosclerosis - December 20, 2021 Category: Cardiology Authors: Luis M Beltr án Romero Antonio J Vallejo-Vaz Ovidio Mu ñiz Grijalvo Source Type: research

Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions
RARITAN, N.J., April 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from new analyses from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefit of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in reducing severe vascular events in patients with PAD after lower-extremity revascularization (LER), a procedure that restores blood flow to the legs. Data from the two analyses demonstrate the role that the XARELTO® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and ...
Source: Johnson and Johnson - April 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Fruit may be good for you, but don’t ditch the statins
Conclusion The study adds to evidence that fresh fruit is likely to be good for our cardiovascular health, although we can't be sure from this study that it definitely prevents deaths, heart attacks or strokes. Observational studies cannot prove that one factor causes another, even when they are as big as this study, because other unmeasured factors could be responsible for the results. In this case, a major potential confounder that the researchers failed to take into account was whether the participants were taking any medication – they only excluded people taking blood pressure tablets. The link with statins, made by ...
Source: NHS News Feed - April 7, 2016 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news