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Condition: Ischemic Stroke
Nutrition: Potassium

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Total 143 results found since Jan 2013.

A Novel Model for Studying Voltage-Gated Ion Channel Gene Expression during Reversible Ischemic Stroke.
In conclusion, to our knowledge, this is the first report of the successful evaluation of voltage-gated ion channel gene expression in TIA and RIND animal models. This model will aid future studies in investigating pathophysiological mechanisms, and in developing new therapeutic compounds for the treatment of TIA and RIND. PMID: 30662329 [PubMed - in process]
Source: International Journal of Medical Sciences - January 22, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models.
Abstract Agmatine (AgM, 100 mg/kg i.p.) effect was tested in parallel at two animal models of cerebral ischemia - rat MCAO model (60'/24 h, 60'/48 h, 90'/24 h, 90'/48 h) and gerbil global ischemia (10') model, administrated 5 min after reperfusion. Aim was to evaluate AgM effect on functional outcome 24 and 48 h after MCAO on neurological and sensor-motor function, and coordination in rats. AgM administration significantly reduced infarct volume, improved neurological score and improved post-ischemic oxidative status. Results of behavioral tests (cylinder test, beam walking test, and adhesive removal...
Source: Brain Research Bulletin - January 11, 2019 Category: Neurology Authors: Selakovic V, Arsenijevic L, Jovanovic M, Sivcev S, Jovanovic N, Leontijevic M, Stojanovic M, Radenkovic M, Andjus P, Radenovic L Tags: Brain Res Bull Source Type: research

Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging
Publication date: Available online 15 October 2018Source: Neurochemistry InternationalAuthor(s): Péter Hertelendy, Dániel P. Varga, Ákos Menyhárt, Ferenc Bari, Eszter FarkasAbstractSecondary injury following acute brain insults significantly contributes to poorer neurological outcome. The spontaneous, recurrent occurrence of spreading depolarization events (SD) has been recognized as a potent secondary injury mechanism in subarachnoid hemorrhage, malignant ischemic stroke and traumatic brain injury. In addition, SD is the underlying mechanism of the aura symptoms of migraineurs. The susceptibility of the nervous tissue...
Source: Neurochemistry International - October 16, 2018 Category: Neuroscience Source Type: research

Astrocyte-specific deletion of Kir6.1/K-ATP channel aggravates cerebral ischemia/reperfusion injury through endoplasmic reticulum stress in mice.
Abstract ATP-sensitive potassium (K-ATP) channels, coupling cell metabolism to cell membrane potential, are involved in brain diseases including stroke. Emerging evidence shows that astrocytes play important roles in the pathophysiology of cerebral ischemia. Kir6.1, a pore-forming subunit of K-ATP channel, is prominently expressed in astrocytes and participates in regulating its function. However, the exact role of astrocytic Kir6.1-containg K-ATP channel (Kir6.1/K-ATP) in ischemic stroke remains unclear. Here, we found that astrocytic Kir6.1 knockout (KO) mice exhibited larger infarct areas and more severe brain ...
Source: Experimental Neurology - October 10, 2018 Category: Neurology Authors: Zhong CJ, Chen MM, Lu M, Ding JH, Du RH, Hu G Tags: Exp Neurol Source Type: research

Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model
In this study, we demonstrated that PHPB improved depressive-like behaviors induced by chronic unpredictable mild stress (CUMS) in rats. Male SD rats were subjected to the stress for five weeks. PHPB (30 and 100 mg/kg) or fluoxetine (FLX 10 mg/kg, as positive control) was administered orally from the third week in CUMS procedure. The behavioral tests were applied and then the biochemical studies were carried out. PHPB or FLX treatment rescued the behavioral deficiency in CUMS-exposed rats. Meanwhile, PHPB normalized the enhanced level of serum corticosterone, improved hippocampal and serum BDNF levels, as well as...
Source: Acta Pharmaceutica Sinica B - August 21, 2018 Category: Cancer & Oncology Source Type: research

The role of KATP channels in cerebral ischemic stroke and diabetes.
Abstract ATP-sensitive potassium (KATP) channels are ubiquitously expressed on the plasma membrane of cells in multiple organs, including the heart, pancreas and brain. KATP channels play important roles in controlling and regulating cellular functions in response to metabolic state, which are inhibited by ATP and activated by Mg-ADP, allowing the cell to couple cellular metabolic state (ATP/ADP ratio) to electrical activity of the cell membrane. KATP channels mediate insulin secretion in pancreatic islet beta cells, and controlling vascular tone. Under pathophysiological conditions, KATP channels play cytoprotect...
Source: Acta Pharmacologica Sinica - April 19, 2018 Category: Drugs & Pharmacology Authors: Szeto V, Chen NH, Sun HS, Feng ZP Tags: Acta Pharmacol Sin Source Type: research

Dissipation of transmembrane potassium gradient is the main cause of cerebral ischemia-induced depolarization in astrocytes and neurons.
Abstract Membrane potential (VM) depolarization occurs immediately following cerebral ischemia and is devastating for the astrocyte homeostasis and neuronal signaling. Previously, an excessive release of extracellular K+ and glutamate has been shown to underlie an ischemia-induced VM depolarization. Ischemic insults should impair membrane ion channels and disrupt the physiological ion gradients. However, their respective contribution to ischemia-induced neuronal and glial depolarization and loss of neuronal excitability are unanswered questions. A short-term oxygen-glucose deprivation (OGD) was used for the purpos...
Source: Experimental Neurology - January 30, 2018 Category: Neurology Authors: Du Y, Wang W, Lutton AD, Kiyoshi CM, Ma B, Taylor AT, Olesik JW, McTigue DM, Askwith CC, Zhou M Tags: Exp Neurol Source Type: research

Condition-specific transcriptional regulation of neuronal ion channel genes in brain ischemia.
The objective of this study is to identify ion channel genes that are differentially regulated under different brain ischemic conditions, as a mean to identify those ion channels that are associated with ischemic brain injury and ischemic tolerance. In mice in vivo, transient focal cerebral ischemia was induced by middle cerebral artery occlusion. In cultured neuronal cells in vitro, simulated ischemia was modeled by oxygen-glucose deprivation. For both in vivo and in vitro studies, three principal ischemic conditions were included: ischemic-preconditioned, injured and tolerant, respectively, plus appropriate controls. In ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 21, 2018 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Dietary Sodium to Potassium Ratio and Risk of Stroke in a Multiethnic Urban Population Clinical Sciences
Conclusions—Na:K intake is an independent predictor of stroke risk. Further studies are required to understand the joint effect of Na and K intake on risk of cardiovascular disease.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Joshua Willey, Hannah Gardener, Sandino Cespedes, Ying K. Cheung, Ralph L. Sacco, Mitchell S.V. Elkind Tags: Diet and Nutrition, Epidemiology, Risk Factors, Ischemic Stroke Original Contributions Source Type: research

The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke
Reactive astrogliosis is one of the significantly pathological features in ischemic stroke accompanied with changes in gene expression, morphology, and proliferation. KCa3.1 was involved in TGF- β-induced astro...
Source: Journal of Neuroinflammation - October 16, 2017 Category: Neurology Authors: Mengni Yi, Tianjiao Wei, Yanxia Wang, Qin Lu, Gaoxian Chen, Xiaoling Gao, Herbert M. Geller, Hongzhuan Chen and Zhihua Yu Tags: Research Source Type: research

Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs.
In this study, we investigated the conversion and pharmacokinetics profiles of dl-PHPB in vitro and in vivo. The conversion of dl-PHPB to dl-NBP was pH- and calcium-dependent, and paraoxonase was identified as a major enzyme for the conversion in rat plasma. The pharmacokinetics, tissue distribution and excretion of dl-PHPB were studied and compared with equal-molar doses of dl-NBP in rats and dogs. The in vivo studies showed that dl-PHPB could be quickly and completely converted to dl-NBP. The plasma concentration-time course of converted dl-NBP after intravenous dl-PHPB administration was nearly the same as that after eq...
Source: Acta Pharmacologica Sinica - September 14, 2017 Category: Drugs & Pharmacology Authors: Li J, Xu SF, Peng Y, Feng N, Wang L, Wang XL Tags: Acta Pharmacol Sin Source Type: research

Comparisons of cardiometabolic biomarkers, lifestyle behaviors, and dietary sodium and potassium intake in a representative sample of Korean adults with and without cardio-cerebrovascular diseases
Conclusion The cardiometabolic condition varied, with hypertensives having a higher prevalence for obesity, high blood pressure, and cholesterol; poorer adherence to the behavioral recommendations was also noted in cardio-cerebrovascular diseases. Such variations in cardiovascular risks would provide implications for addressing vulnerability across groups.
Source: Asian Nursing Research - August 17, 2017 Category: Nursing Source Type: research

Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron –astrocyte co-culture system through neurotrophy and neuroinflammation pathway
In conclusion, the present study demonstrates that the neuroprotective effects of d,l-PHPB were improved by astrocytes, mainly mediated by increasing the release of BDNF/NGF and attenuating inflammatory cytokines. Graphical abstract
Source: Acta Pharmaceutica Sinica B - July 15, 2017 Category: Cancer & Oncology Source Type: research

Invited Commentary: Can Estimation of Sodium Intake Be Improved by Borrowing Information From Other Variables?
AbstractEstimation of dietary sodium intake is problematic. The most accurate measure is average sodium excretion from multiple 24-hour urine collections, but such an approach is impractical. Using data from the Women's Health Initiative, Prentice et al. (Am J Epidemiol. 2017;186(9):1035 –1043) assessed the relationship of calibrated estimates of sodium and potassium excretion with cardiovascular outcomes. The calibrated estimates were a function of self-reported sodium-to-potassium ratio from a food frequency questionnaire, age, body mass index, race, supplement use, smoking stat us, educational level, income, and aspir...
Source: American Journal of Epidemiology - June 14, 2017 Category: Epidemiology Source Type: research

Associations of Biomarker-Calibrated Sodium and Potassium Intakes With Cardiovascular Disease Risk Among Postmenopausal Women
AbstractStudies of the associations of sodium and potassium intakes with cardiovascular disease incidence often rely on self-reported dietary data. In the present study, self-reported intakes from postmenopausal women at 40 participating US clinical centers are calibrated using 24-hour urinary excretion measures in cohorts from the Women's Health Initiative, with follow-up from 1993 to 2010. The incidence of hypertension was positively related to (calibrated) sodium intake and to the ratio of sodium to potassium. The sodium-to-potassium ratio was associated with cardiovascular disease incidence during an average follow-up ...
Source: American Journal of Epidemiology - June 14, 2017 Category: Epidemiology Source Type: research