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Condition: Ischemic Stroke
Drug: Diprivan

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Total 35 results found since Jan 2013.

Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy
There is limited data on the safety, hemodynamic profile, and outcome of patients undergoing intra-arterial therapy (IAT) for acute ischemic stroke (AIS) under sedation with dexmedetomidine (DEX) versus propofol (PROP).
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2015 Category: Neurology Authors: Seby John, Jaspreet Somal, Umera Thebo, Muhammad S. Hussain, Ehab Farag, Suzanne Dupler, Joao Gomes Source Type: research

The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy —A Matched Pair Analysis
ConclusionAn SOP using a novel sedation regimen and optimization of equipment and procedures directed at a leaner, more integrative and compact periinterventional management can reduce in-house treatment delays significantly in stroke patients receiving thrombectomy in light sedation and demonstrated the safety and feasibility of our improved approach.
Source: Neurocritical Care - January 18, 2019 Category: Neurology Source Type: research

Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke
In this study, propofol administration significantly reduced the neurotoxic aggregation of α-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demo nstrated that the propofol-induced reduction of α-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke.
Source: Neuroscience Bulletin - September 12, 2019 Category: Neuroscience Source Type: research

Cerebral protection during neurosurgery and stroke
This article reviews the recent evidence on perioperative neuroprotection in patients undergoing brain surgery and in patients with acute stroke. Recent findings: With varying degrees of success, numerous pharmacological and nonpharmacological therapies have been employed to provide neuroprotection for patients during the perioperative period and after acute ischemic stroke (IAS). Recent studies have failed to demonstrate neuroprotective effects of intraoperative remifentanil or propofol use, although hypertonic saline may provide better brain relaxation than mannitol during elective intracranial surgery for tumor. Magnesi...
Source: Current Opinion in Anaesthesiology - September 3, 2015 Category: Anesthesiology Tags: NEUROANESTHESIA: Edited by Keith J. Ruskin Source Type: research

Intravenous Propofol Versus Volatile Anesthetics For Stroke Endovascular Thrombectomy
Conclusion: In stroke patients undergoing endovascular thrombectomy treated using general anesthesia, there may be a differential effect between intravenous propofol and volatile inhalational agents. These results should be considered hypothesis-generating and be tested in future randomized controlled trials.
Source: Journal of Neurosurgical Anesthesiology - December 11, 2020 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Anaesthesia practices for endovascular therapy of acute ischaemic stroke: a Nordic survey
ConclusionsThis survey indicates that the majority of Nordic anaesthesia departments who manage anaesthesia for EVT are able to provide immediate 24‐h response to an EVT request. Most of these departments have institutional guidelines for EVT anaesthesia and haemodynamic management. Conscious sedation appears to be the preferred method of anaesthetic care.
Source: Acta Anaesthesiologica Scandinavica - July 1, 2017 Category: Anesthesiology Authors: M. Rasmussen, C. Z. Simonsen, L. H. S ørensen, S. Dyrskog, D. A. Rusy, D. Sharma, N. Juul Tags: Original Article Source Type: research

Assessment of Anesthesia Practice Patterns for Endovascular Therapy for Acute Ischemic Stroke: A Society for Neuroscience in Anesthesiology and Critical Care (SNACC) Member Survey
Conclusions: There is wide variation in anesthesia technique and hemodynamic management during EVT for AIS, and no consensus on the choice of, or preferred medications for, GA or CS, or target blood pressure and management of hypotension during the procedure.
Source: Journal of Neurosurgical Anesthesiology - September 19, 2021 Category: Anesthesiology Tags: Short Reports Source Type: research

The Outcome of Status Epilepticus and Long-Term Follow-Up
Conclusion: This study highlights the importance of regular care and patient follow-up. Introduction Status epilepticus (SE) is a condition and most extreme form of epilepsy (1), which leads to abnormal and prolonged seizure (at least 5 min). In case SE persists over 30 min, it may have severe long-term consequences (2). Referring to the new classification scheme of SE, there are two operational dimensions of the definition: time point 1 (T1) is associated with abnormally prolonged seizure, when therapy should be initiated, while time point 2 (T2) is related to the time of on-going seizure activity involving a risk...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Propofol Enhances Hemoglobin-Induced Cytotoxicity in Neurons.
CONCLUSIONS: These results from our current proof-of-concept study should promote more research in vitro and in vivo to develop better anesthesia care for patients with hemorrhagic stroke. PMID: 26771264 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - January 14, 2016 Category: Anesthesiology Authors: Yuan J, Cui G, Li W, Zhang X, Wang X, Zheng H, Zhang J, Xiang S, Xie Z Tags: Anesth Analg Source Type: research

Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF- κB signaling in ischemic brain injury in rats
Conclusion Propofol post-conditioning either with nobiletin prior I/R injury was found to be more effective than propofol alone, suggesting the positive effects of nobiletin on propofol-mediated anti-inflammatory and neuroprotective effects.
Source: Biomedicine and Pharmacotherapy - May 4, 2017 Category: Drugs & Pharmacology Source Type: research

Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF- κB signaling in ischemic brain injury in rats.
CONCLUSION: Propofol post-conditioning either with nobiletin prior I/R injury was found to be more effective than propofol alone, suggesting the positive effects of nobiletin on propofol-mediated anti-inflammatory and neuroprotective effects. PMID: 28478273 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2017 Category: Drugs & Pharmacology Authors: Zheng Y, Bu J, Yu L, Chen J, Liu H Tags: Biomed Pharmacother Source Type: research

Volatile anaesthetics versus propofol in the cardiac surgical setting of remote ischaemic preconditioning: a secondary analysis of a Cochrane Systematic Review.
CONCLUSIONS: Present data do not permit a final assessment regarding the role of volatile or intravenous anaesthetics as a possible confounding factor in RIPC trials. PMID: 29945432 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - June 28, 2018 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Endovascular treatment of intracranial arteriovenous malformation with n-butyl cyanoacrylate. Working methods and experience in 58 cases.
CONCLUSIONS: The rates of total occlusion and of morbidity and mortality in the series are in the internationally described ranges. The implementation of intranidal closings with 20-30% devascularization per session and the use of post-embolization hypotension after the haemorrhage complications described resulted in the total absence of haemorrhagic complications. PMID: 23566543 [PubMed - in process]
Source: Neurocirugia - May 1, 2013 Category: Neurosurgery Authors: Jordan González JA, Llibre Guerra JC, Prince López JA, Vázquez Luna F, Rodríguez Ramos RM, Ugarte Suarez JC Tags: Neurocirugia (Astur) Source Type: research

Early neurological complications after transcatheter closure of atrial septal defect with nitinol wire mesh occluder.
Abstract Atrial septal defect (ASD) was closed percutaneously in an 18-year-old boy with a 27 mm nitinol wire mesh occluder according to standard procedures. Three hours after the procedure, he presented anxiety attacks, aggression, a vacant stare and a verbal/speaking disorder. Small ischaemic stroke localised in the right temporal/parietal region of the central nervous system was confirmed by computed tomography examination. Activated partial thromboplastin time was then 54 s despite continuous heparin infusion. Heparin dose was increased and symptomatic treatment was introduced (mannitol, furosemide, propofol, ...
Source: Polish Heart Journal - September 27, 2013 Category: Cardiology Authors: Heredia JD, Szkutnik M, Fiszer R, Zyła-Frycz M, Białkowski J Tags: Kardiol Pol Source Type: research

Methodology of Motor Evoked Potentials in a Rabbit Model
This study provides the basis for a reproducible model of SCI to be used for novel therapeutic drug development.
Source: Translational Stroke Research - May 20, 2015 Category: Neurology Source Type: research