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Condition: Epilepsy

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Total 2623 results found since Jan 2013.

1. Epileptic seizures in pediatric stroke: Data from the Italian Registry for Childhood Thrombosis
According to data from the Italian Registry for Childhood Thrombosis (R.I.T.I.), in about half cases diagnosis of pediatric stroke occurs after 24h from clinical onset (Baggio et al., SINP2013). The aim of the present study was to evaluate the frequency of seizures at stroke onset and their correlation with time to diagnosis in the pediatric stroke patients in the R.I.T.I. We selected the R.I.T.I. children with first acute arterial (AIS) or venous (CSVT) cerebral infarction occurring between January 2007 and June 2012; we studied prevalence, characteristics and recurrence of epileptic seizures, focusing on diagnostic delay.
Source: Clinical Neurophysiology - December 13, 2014 Category: Neuroscience Authors: L. Baggio, S. Sartori, M. Nosadini, C. Gentilomo, P. Saracco, M. Agostini, B. Bassi, A. Palmieri, A.M. Laverda, P. Simioni, A. Suppiej, per il G.I.R.T.I. (Gruppo Italiano Registro Trombosi Infantili) Source Type: research

Epidemiology of neurological disorders in India: Review of background, prevalence and incidence of epilepsy, stroke, Parkinson's disease and tremors
M Gourie-DeviNeurology India 2014 62(6):588-598Growth and development of neuroepidemiology in India during the last four decades has been documented highlighting the historical milestones. The prevalence rates of the spectrum of neurological disorders from different regions of the country ranged from 967-4,070 with a mean of 2394 per 100000 population, providing a rough estimate of over 30 million people with neurological disorders (excluding neuroinfections and traumatic injuries). Prevalence and incidence rates of common disorders including epilepsy, stroke, Parkinson's disease and tremors determined through popul...
Source: Neurology India - January 16, 2015 Category: Neurology Authors: M Gourie-Devi Source Type: research

Can statins prevent seizures after strokes?
People who have had strokes are at increased risk of developing seizures and epilepsy. In the article "Statin treatment reduces the risk of poststroke seizures," Guo and colleagues looked at whether treating patients who had recently had a stroke with a cholesterol-lowering "statin" medication might reduce the risk of developing seizures following the stroke.1
Source: Neurology - August 24, 2015 Category: Neurology Authors: Motika, P. V. Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, All Epilepsy/Seizures PATIENT PAGES Source Type: research

Statin treatment reduces the risk of poststroke seizures
Conclusions: Statin use, especially in the acute phase, may reduce the risk of poststroke early-onset seizures. In addition, statin treatment may prevent the progression of initial poststroke seizure-induced neurodegeneration into chronic epilepsy. Because of the observational nature of the study, more studies are needed to confirm the results. Classification of evidence: This study provides Class III evidence that in patients with a first-ever ischemic stroke, the early use of statins reduces the risk of early poststroke seizures.
Source: Neurology - August 24, 2015 Category: Neurology Authors: Guo, J., Guo, J., Li, J., Zhou, M., Qin, F., Zhang, S., Wu, B., He, L., Zhou, D. Tags: All Cerebrovascular disease/Stroke, Antiepileptic drugs ARTICLE Source Type: research

Factors Influencing Non-Persistence with Antiplatelet Medications in Elderly Patients After Ischaemic Stroke
Conclusions Our results suggest that women, patients aged <75 years, and patients without certain comorbid conditions may need improved assistance in secondary prevention management after an ischaemic stroke.
Source: Drugs and Aging - March 28, 2016 Category: Geriatrics Source Type: research

Post-Stroke Epilepsy in Burkina Faso (West Africa)
Post-stroke epilepsy (PSE) is defined as “recurrent seizures following stroke with confirmed diagnosis of epilepsy”. Our objective was to describe the epidemiological, clinical and therapeutic PSE aspects at the Yalgado Ouedraogo Teaching Hospital, the main reference centre for neurological conditions in Burkina Faso. We conducted a retrospective study from January 2006 to December 2014. The data on thirty-two (32) cases of PSE was collected from a total of 1616 patients hospitalized for stroke, representing a rate of 1.98%.
Source: Journal of the Neurological Sciences - June 23, 2016 Category: Neurology Authors: Christian Napon, Anselme Dabilgou, Julie Kyelem, Jean Kaboré Tags: Clinical Short Communication Source Type: research

Post-stroke epilepsy in Burkina Faso (West Africa)
Post-stroke epilepsy (PSE) is defined as “recurrent seizures following stroke with confirmed diagnosis of epilepsy”. Our objective was to describe the epidemiological, clinical and therapeutic PSE aspects at the Yalgado Ouedraogo Teaching Hospital, the main reference centre for neurological conditions in Burkina Faso. We conducted a re trospective study from January 2006 to December 2014. The data on thirty-two (32) cases of PSE was collected from a total of 1616 patients hospitalized for stroke, representing a rate of 1.98%.
Source: Journal of the Neurological Sciences - June 23, 2016 Category: Neurology Authors: Christian Napon, Anselme Dabilgou, Julie Kyelem, Jean Kabor é Tags: Clinical short communication Source Type: research

NS1209/SPD 502, A Novel Selective AMPA Antagonist for Stroke, Neuropathic Pain or Epilepsy? Drug Development Lessons Learned
ABSTRACT The selective AMPA (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid) receptor antagonist, NS1209 (also known as SPD 502) has been explored in several research and development campaigns since its selection as a lead drug candidate in the early 1990s by the Danish biotechnology company, NeuroSearch. The compound was successively tested in animal models of stroke, neuropathic pain and epilepsy. The preclinical data to support development for the treatment of stroke were incomplete, as the compound was administered after the stroke episode, and did not protect subcortical areas of the brain....
Source: Drug Development Research - January 31, 2017 Category: Drugs & Pharmacology Authors: Jan M. Keppel Hesselink Tags: Miscellaneous Source Type: research

Pediatric arterial ischemic stroke: Epidemiology, risk factors, and management
Publication date: Available online 7 March 2017 Source:Blood Cells, Molecules, and Diseases Author(s): Ryan J. Felling, Lisa R. Sun, Emily C. Maxwell, Neil Goldenberg, Timothy Bernard Pediatric arterial ischemic stroke (AIS) is an uncommon but important cause of neurologic morbidity in neonates and children, with consequences including hemiparesis, intellectual disabilities, and epilepsy. The causes of pediatric AIS are unique to those typically associated with stroke in adults. Familiarity with the risk factors for AIS in children will help with efficient diagnosis, which is unfortunately frequently delayed. Here we revi...
Source: Blood Cells, Molecules, and Diseases - March 7, 2017 Category: Hematology Source Type: research

Acute ischemic stroke in a young female: a novel presentation of anti-GAD autoimmunity (P3.272)
Conclusions:Restricted diffusion, seen typically in ischemia, indicates cytotoxic oedema and irreversible cell damage. In this patient, we postulate a mechanism of severe CNS inflammation with cellular toxicity and small vessel vasculitis. Anti-GAD autoimmunity should be considered in young patients presenting with stroke-like episodes, particularly when accompanied by positive phenomenon.Disclosure: Dr. Neo has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Neo, X. S., Lee, K. E., Lee, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Importance of Distinguishing Between Mitochondrial Encephalomyopathy With Elderly Onset of Stroke-Like Episodes and Cerebral Infarction.
Abstract The most common disease-causing mitochondrial DNA (mtDNA) mutation in mitochondrial encephalomyopathy (ME) with lactic acidosis and stroke-like episodes (MELAS) is m.3243A>G. In the future, the incidence of patients with cerebral infarction and diabetes mellitus is expected to increase tremendously. Additionally, the A3243G mutation typical of diabetes is estimated to be present in approximately 2% of all diabetes patients, which suggests that the potential disease population with a mitochondrial disorder is greater than previously thought, and there may have been many cases among the elderly that were...
Source: Clin Med Res - August 18, 2017 Category: Research Authors: Tetsuka S, Tagawa A, Ogawa T, Otsuka M, Hashimoto R, Kato H Tags: J Clin Med Res Source Type: research

Place of EEG in the management of arterial ischemic stroke newborn.
Abstract The EEG has a key role in the management of neonatal seizures, which are the typical mode of revelation of neonatal ischemic stroke. The EEG should be started as soon as possible in case of suspected seizure. Some EEG features are evocative of neonatal stroke, typically asymmetry of background activity with the presence of focal spikes and focal seizures. The EEG should be prolonged and always associated with a video as pauci-symptomatic or subclinical seizures are frequent, including some status epilepticus. Video-EEG monitoring is therefore essential to judge the efficacy of anticonvulsant therapy. Ther...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Nguyen The Tich S Tags: Arch Pediatr Source Type: research

Association between different acute stroke therapies and development of post stroke seizures
Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improv...
Source: BMC Neurology - May 3, 2018 Category: Neurology Authors: Jillian Naylor, Arthur Thevathasan, Leonid Churilov, Ruibing Guo, Yunyun Xiong, Miriam Koome, Ziyi Chen, Ziyuan Chen, Xinfeng Liu, Patrick Kwan and Bruce C. V. Campbell Tags: Research article Source Type: research

Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS)
Publication date: Available online 18 June 2018Source: Journal of Clinical NeuroscienceAuthor(s): Xiaodi Li, Yuzhou Wang, Zhanhang Wang, Jianjun Lu, Yan Xu, Jinlong Ye, Zuying Kuang, Bo Li, Mengqiu Pan, Wenming Chen, Shuisheng Lu, Ziyang Zhou, Lina Cheng, Honghao WangAbstractTo compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MR...
Source: Journal of Clinical Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Prognosis of post-stroke status epilepticus: effects of time difference between the two events
In status epilepticus (SE), the etiology is a major determinant of the prognosis [1]. Hence, it is essential to investigate each cause of this condition and establish prognostic estimations and therapeutic guidelines accordingly. Cerebrovascular disease is one of the most common causes of SE, and the prevalence of stroke increases with aging. Nonetheless, SE is seldom described in studies reporting post-stroke seizures, and few reports have focused exclusively on post-stroke SE (PSSE).
Source: Seizure: European Journal of Epilepsy - July 9, 2018 Category: Neurology Authors: Estevo Santamarina, Laura Abraira, Manuel Toledo, Montserrat Gonz ález-Cuevas, Manuel Quintana, Olga Maisterra, María Sueiras, Lorena Guzman, Javier Salas-Puig, José Álvarez Sabín Source Type: research