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Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions
Improvements in acute stroke care, namely the use of intravenous alteplase (IV-tPA) and mechanical thrombectomy (MT), have led to a considerable increase in the proportion of patients who survive a first-time ischemic stroke.1 Despite demonstrated benefits of acute stroke interventions, their impact on long term complications is not yet clear. One such complication is post-ischemic stroke epilepsy (PISE). PISE is estimated to occur in 2 –6% of stroke survivors,2–4 and is associated with poor-quality of life and high mortality in young patients.
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2021 Category: Neurology Authors: Lindsey R. Kuohn, Alison L. Herman, Alexandria L. Soto, Stacy C. Brown, Emily J. Gilmore, Lawrence J. Hirsch, Charles C. Matouk, Kevin N. Sheth, Jennifer A. Kim Source Type: research

Is the outpatient management of acute minor stroke feasible and safe?
Paul et al1 have assessed the clinical outcomes, early hospital admission rates and hospital care costs in clinic referred and hospital referred minor stroke patients in a prospective population based study. They did not find significant differences in the 30 day admission rate in clinic patients compared with the 30 day readmission rate after discharge in hospital treated patients (16/237 vs 9/150). The 30 day recurrent stroke risk in patients with minor ischaemic stroke was also similar in those discharged from clinic compared with hospital patients (3.8% vs 5.3%; p=0.61). The recurrent stroke risk remained similar in pa...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Csiba, L. Tags: Epilepsy and seizures, Stroke, Hypertension Editorial commentaries Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Quick magnesium treatment fails to improve stroke outcomes, but study has silver lining
In the first study of its kind, a consortium led by UCLA physicians found that giving stroke patients intravenous magnesium within an hour of the onset of symptoms does not improve stroke outcomes.   However, the 8-year trial did find that with the help of paramedics in the field, intravenous medications can frequently be administered to stroke victims within that so-called "golden hour," during which they have the best chance to survive and avoid debilitating, long-term neurological damage.   The latter finding is a "game-changer," said Dr. Jeffrey Saver, director of the UCLA Stroke Center and a professor of ...
Source: UCLA Newsroom: Health Sciences - February 13, 2014 Category: Universities & Medical Training Source Type: news

Acute symptomatic seizures and hippocampal sclerosis: the major contributor for post-stroke epilepsy?
AbstractObjectiveHippocampal sclerosis (HS) is a prominent biomarker of epilepsy. If acquired later in life, it usually occurs in the context of degenerative or acute inflammatory-infectious disease. Conversely, acute symptomatic seizures (ASS) are considered a risk factor for developing post-stroke epilepsy, but other factors remain unrecognized. Here, we hypothesize that silent hippocampal injury contributes to the development of post-stroke epilepsy.MethodsWe performed a retrospective observational study of patients hospitalized between 1/2007 and 12/2018 with an acute stroke in the Stroke Center of the Geneva Universit...
Source: Journal of Neurology - July 7, 2022 Category: Neurology Source Type: research

In‐hospital costs in patients with seizures and epilepsy after stroke
Summary ObjectivesTo verify the net effect of seizures after stroke on the use of in‐hospital health care resources. MethodsConsecutive patients with first‐ever stroke were admitted to the stroke unit of a Moscow hospital and followed prospectively until death or discharge. Each patient experiencing seizures was matched for age, sex, stroke type, National Institutes of Health Stroke Scale score at admission, and stroke risk factors to 2+ patients with no seizures, as controls. Resources consumed included length of hospital stay, admission to the intensive care unit (ICU), diagnostic tests, medical consultations and tre...
Source: Epilepsia - June 13, 2015 Category: Neurology Authors: Alla Guekht, Maria Mizinova, Andrey Ershov, Denis Guz, Igor Kaimovsky, Paolo Messina, Ettore Beghi Tags: Full‐Length Original Research Source Type: research

Impact of acute symptomatic seizures and their management on patient-reported outcomes after stroke
The objective of our study is to evaluate the association between PROMs and ASyS and ASMs following stroke.METHODS: We performed a retrospective cohort study of all stroke patients who underwent inpatient continuous EEG (cEEG) monitoring performed due to suspected ASyS, including the ones with observed convulsive ASyS, from 04/01/2012 to 03/31/2018, who completed PROMs within 6 months of hospital discharge. Patient-reported outcome measures, including one Neuro-QoL and six PROMIS v1.0 domain scales, were completed by patients as the standard of care in ambulatory stroke clinics. Since ASMs are sometimes used without clearl...
Source: Epilepsy and Behaviour - February 22, 2023 Category: Neurology Authors: Vineet Punia Yadi Li Brittany Lapin Pradeep Chandan Christopher Newey Stephen Hantus Monika Dhakar Clio Rubinos Sahar Zafar Adithya Sivaraju Irene L Katzan for Post-Acute Symptomatic Seizure Investigation and Outcomes Network (PASSION) investigators Source Type: research

Does treatment with t-PA increase the risk of developing epilepsy after stroke?
This study failed to identify treatment with t-PA as an independent risk factor for PSE.
Source: Journal of Neurology - July 24, 2015 Category: Neurology Source Type: research

The Association Between Atrial Fibrillation and Poststroke Seizures is Influenced by Ethnicity and Environmental Factors
This study assessed whether ethnicity affects the association between AF and poststroke seizure (PSS) development. We hypothesized that Royal Melbourne Hospital ([RMH] Melbourne) patients will have significantly higher incidence of AF-related PSS than in the Jinling Hospital (Nanjing) population.
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2018 Category: Neurology Authors: Jillian Naylor, Leonid Churilov, Benjamin Johnstone, Ruibing Guo, Yunyun Xiong, Miriam Koome, Ziyi Chen, Arthur Thevathasan, Ziyuan Chen, Xinfeng Liu, Patrick Kwan, Bruce C.V. Campbell Source Type: research

Post-Stroke Epilepsy in Burkina Faso (West Africa)
Post-stroke epilepsy (PSE) is defined as “recurrent seizures following stroke with confirmed diagnosis of epilepsy”. Our objective was to describe the epidemiological, clinical and therapeutic PSE aspects at the Yalgado Ouedraogo Teaching Hospital, the main reference centre for neurological conditions in Burkina Faso. We conducted a retrospective study from January 2006 to December 2014. The data on thirty-two (32) cases of PSE was collected from a total of 1616 patients hospitalized for stroke, representing a rate of 1.98%.
Source: Journal of the Neurological Sciences - June 23, 2016 Category: Neurology Authors: Christian Napon, Anselme Dabilgou, Julie Kyelem, Jean Kaboré Tags: Clinical Short Communication Source Type: research

Post-stroke epilepsy in Burkina Faso (West Africa)
Post-stroke epilepsy (PSE) is defined as “recurrent seizures following stroke with confirmed diagnosis of epilepsy”. Our objective was to describe the epidemiological, clinical and therapeutic PSE aspects at the Yalgado Ouedraogo Teaching Hospital, the main reference centre for neurological conditions in Burkina Faso. We conducted a re trospective study from January 2006 to December 2014. The data on thirty-two (32) cases of PSE was collected from a total of 1616 patients hospitalized for stroke, representing a rate of 1.98%.
Source: Journal of the Neurological Sciences - June 23, 2016 Category: Neurology Authors: Christian Napon, Anselme Dabilgou, Julie Kyelem, Jean Kabor é Tags: Clinical short communication Source Type: research

Importance of Distinguishing Between Mitochondrial Encephalomyopathy With Elderly Onset of Stroke-Like Episodes and Cerebral Infarction.
Abstract The most common disease-causing mitochondrial DNA (mtDNA) mutation in mitochondrial encephalomyopathy (ME) with lactic acidosis and stroke-like episodes (MELAS) is m.3243A>G. In the future, the incidence of patients with cerebral infarction and diabetes mellitus is expected to increase tremendously. Additionally, the A3243G mutation typical of diabetes is estimated to be present in approximately 2% of all diabetes patients, which suggests that the potential disease population with a mitochondrial disorder is greater than previously thought, and there may have been many cases among the elderly that were...
Source: Clin Med Res - August 18, 2017 Category: Research Authors: Tetsuka S, Tagawa A, Ogawa T, Otsuka M, Hashimoto R, Kato H Tags: J Clin Med Res Source Type: research

Neighborhood Type Tied to Post-Stroke Mortality Risk Neighborhood Type Tied to Post-Stroke Mortality Risk
Living in a disadvantaged neighborhood may hike mortality risk after discharge from the hospital for stroke, epilepsy, or other neurologic conditions, new research suggests.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - February 22, 2023 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Reversible leukoencephalopathy as a presentation of cerebral amyloid angiopathy
A 73 year old man with a past medical history of hypertension, osteoathritis and asthma presented to the local district general hospital with recurrent episodes of spontaneously resolving encephalopathy. The initial presentation was characterised by acute confusion and visual hallucinations followed by a generalised tonic–clonic seizure. On examination his blood pressure was 215/115 mmHg. Neurological examination did not reveal any lateralising signs but the patient was found to be encephalopathic with a Montreal Cognitive Assessment (MOCA) score of 9/30. Routine blood tests were unremarkable. A CT brain scan showed ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Lilleker, J., Vassallo, J., Punter, M. Tags: Genetics, Immunology (including allergy), Epilepsy and seizures, Stroke, Hypertension, Drugs: psychiatry, Radiology, Surgical diagnostic tests Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23 Source Type: research

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