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Condition: Anaphylactic Shock

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Total 7645 results found since Jan 2013.

Ara h 2 and Ara 6 are the best predictors of severe peanut allergy: A double‐blind placebo‐controlled study
ConclusionCo‐sensitization to Ara h 2 and Ara h 6 was associated with severe reactions distinguishing severe allergy from mild symptoms. SIgE to Ara h 8 added no diagnostic value. Component‐resolved diagnostics reduce the need for oral challenges in peanut allergy.This article is protected by copyright. All rights reserved.
Source: Allergy - June 11, 2015 Category: Allergy & Immunology Authors: Anna Kaarina Kukkonen, Anna S. Pelkonen, Soili Mäkinen‐Kiljunen, Helena Voutilainen, Mika J. Mäkelä Tags: Original Article Source Type: research

Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment
Abstract Food allergy is defined as an IgE-mediated hypersensitivity response to ingested food with allergic symptoms ranging from urticaria to life-threatening anaphylaxis. Food allergy is thought to develop because of (1) failed induction of tolerance upon initial exposure to food antigen or (2) breakdown of established tolerance to food antigen. We review current understanding of the pathogenesis, epidemiology, and natural history of food allergy, including the unconventional IgE-mediated food allergy to mammalian meat known as alpha-gal food allergy. We highlight emerging data on food allergy treatment and pr...
Source: Current Allergy and Asthma Reports - April 3, 2016 Category: Allergy & Immunology Source Type: research

Diagnostic Value of Antigen-Specific Immunoglobulin E Immunoassays against Ara h 2 and Ara h 8 Peanut Components in Child Food Allergy
Conclusions: We propose an algorithm for a better use of peanut component sIgE immunoassays that should improve their diagnostic value and avoid unnecessary OFC.Int Arch Allergy Immunol 2016;169:216-222
Source: International Archives of Allergy and Immunology - May 26, 2016 Category: Allergy & Immunology Source Type: research

Introduction of peanuts in younger siblings of children with peanut allergy: a prospective, double‐blinded assessment of risk, of diagnostic tests and an analysis of patient preferences
ConclusionsThere is an increased risk of anaphylaxis upon peanut introduction in siblings of children with peanut allergy and parents are reluctant to introduce at home without testing. Allergy testing prior to introduction is negative in over 90% of cases and carries a high negative predictive value.This article is protected by copyright. All rights reserved.
Source: Allergy - June 12, 2016 Category: Allergy & Immunology Authors: Philippe Bégin, François Graham, Kerstin Killer, Jean Paradis, Louis Paradis, Anne Des Roches Tags: Original Article: Anaphylaxis Source Type: research

Introduction of peanuts in younger siblings of children with peanut allergy: a prospective, double ‐blinded assessment of risk, of diagnostic tests, and an analysis of patient preferences
ConclusionsThere is an increased risk of anaphylaxis upon peanut introduction in siblings of children with peanut allergy, and parents are reluctant to introduce at home without testing. Allergy testing prior to introduction is negative in over 90% of cases and carries a high negative predictive value.
Source: Allergy - July 10, 2016 Category: Allergy & Immunology Authors: P. B égin, F. Graham, K. Killer, J. Paradis, L. Paradis, A. Des Roches Tags: Original Article Source Type: research

Impaired health-related quality of life in adolescents with allergy to staple foods
ConclusionsAs ascertained via a food allergy-specific questionnaire, adolescents with staple food allergy report poorer than average HRQL, specifically in relation to emerging independence and the need for support. Girls have clinically worse HRQL than boys. The number and type of previous symptoms and history of anaphylaxis were not associated with worse HRQL.
Source: Clinical and Translational Allergy - September 29, 2016 Category: Allergy & Immunology Source Type: research

Racial Differences in Food Allergy Phenotype and Health Care Utilization among US Children
Conclusions FA phenotypes and health care utilization differ among children of different racial and/or ethnic backgrounds in the United States that put AA and Hispanic children at higher risks of adverse outcome than white children. These differences include coexistent atopic conditions, less well recognized food allergens, and higher rates of anaphylaxis.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 22, 2016 Category: Allergy & Immunology Source Type: research

Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy
Conclusions and Clinical RelevanceH. pylori confers protection against the anaphylaxis associated with ovalbumin and peanut allergy and affects the epigenome of T‐cells, thereby promoting stable Treg differentiation and functionality. Prophylactic treatment with H. pylori‐derived immunomodulators appears to be a promising strategy for food allergy prevention.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - August 12, 2017 Category: Allergy & Immunology Authors: Andreas Kyburz, Sabine Urban, Aleksandra Altobelli, Stefan Floess, Jochen Huehn, Timothy L. Cover, Anne M üller Tags: Original Article ‐Experimental Models of Allergic Disease Source Type: research

IgE promotes type 2 innate lymphoid cells in murine food allergy
Conclusions & clinical relevanceThese findings support an important role for IgE‐activated mast cells in driving intestinal ILC2 expansion in food allergy and reveal that ILC2, in turn, can enhance responsiveness to the mediators of anaphylaxis produced by mast cells. Strategies designed to inhibit IgE signaling or mast cell activation are likely to inhibit both Type 2 immunity and immediate hypersensitivity in food allergy.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - December 1, 2017 Category: Allergy & Immunology Authors: Oliver T. Burton, Jaciel Medina Tamayo, Amanda J. Stranks, Samuel Miller, Kyle J. Koleoglou, Ellen O. Weinberg, Hans C. Oettgen Tags: Original Article ‐Basic Mechanisms in Allergic Disease Source Type: research

Predictors of Persistent Milk Allergy in Children: A Retrospective Cohort Study
Conclusions: The history of anaphylaxis and high milk-specific IgE levels were associated with persistent CM allergy.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 23, 2018 Category: Allergy & Immunology Source Type: research

A multicenter evaluation of diagnosis and management of omega-5 gliadin allergy (also known as wheat-dependent exercise induced anaphylaxis) in 132 adults
Conclusions Omega-5 gliadin allergy is a rare wheat allergy that presents with severe anaphylaxis. The diagnosis is frequently delayed, therefore we recommend that all adult patients presenting with anaphylaxis of unclear cause should have omega-5 gliadin specific IgE tested. A gluten-free diet or avoidance of wheat based meals in combination with exercise (if the cofactor is exercise) helps to significantly decrease the risk of future allergic reactions. However, antihistamines and an epinephrine auto-injector must always be prescribed, as a third of patients continue to have allergic reactions despite dietary advice.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 2, 2018 Category: Allergy & Immunology Source Type: research

The Impact of Baked Egg and Baked Milk Diets on IgE- and Non-IgE-Mediated Allergy
AbstractBaked milk (BM) and baked egg (BE) diets are increasingly used in the management of milk and egg allergy, rather than avoidance. Children with tolerance versus reactivity to BM and BE may have smaller skin prick test and lower specific IgE, and BM-tolerant children have less basophil reactivity and more peripheral T regulatory cells. However, most milk- and egg-allergic children tolerate BM and BE and an individual ’s reactivity is unpredictable. Non-reactivity is due to conformational changes in the allergens. Significant differences in the published advice about methods of introduction exist from graded introdu...
Source: Clinical Reviews in Allergy and Immunology - March 8, 2018 Category: Allergy & Immunology Source Type: research

Predictors of Persistent Wheat Allergy in Children: A Retrospective Cohort Study
Conclusions: A history of anaphylaxis to all foods including wheat and/or a high level of wheat- or ω-5 gliadin-specific IgE antibodies were identified as risk factors for persistent wheat allergy.Int Arch Allergy Immunol 2018;176:1 –6
Source: International Archives of Allergy and Immunology - June 5, 2018 Category: Allergy & Immunology Source Type: research

Vaccine Allergy? Skin testing and challenge at a tertiary pediatric hospital in Melbourne, Australia
ConclusionThe vast majority of children (92%) presenting with a potential IgE-mediated AEFI are able to tolerate challenge to suspect vaccine without reaction. We present our investigation protocol recommending skin testing in all children with anaphylaxis and challenge with suspect vaccine if negative testing or previous non-anaphylactic potential IgE mediated AEFI.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 23, 2019 Category: Allergy & Immunology Source Type: research

Identifying Low-risk Beta-Lactam allergy Patients in a UK Tertiary Centre
ConclusionWe identified a “low risk” cohort of patients where the history is of similar reliability to skin testing in predicting non-allergic status for BL allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 26, 2019 Category: Allergy & Immunology Source Type: research