Vaccine Allergy? Skin testing and challenge at a tertiary pediatric hospital in Melbourne, Australia

ConclusionThe vast majority of children (92%) presenting with a potential IgE-mediated AEFI are able to tolerate challenge to suspect vaccine without reaction. We present our investigation protocol recommending skin testing in all children with anaphylaxis and challenge with suspect vaccine if negative testing or previous non-anaphylactic potential IgE mediated AEFI.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research