Filtered By:
Condition: SARS
This page shows you your search results in order of date.
Order by Relevance | Date
Total 101244 results found since Jan 2013.
Characterization of pre-existing anti-PEG and anti-AGAL antibodies towards PRX-102 in patients with Fabry disease
Polyethylene glycol (PEG)ylated drugs are used for medical treatment, since PEGylation either decreases drug clearance or/and shields the protein from undesirable immunogenicity. PEGylation was implemented in a new enzyme replacement therapy for Fabry disease (FD), pegunigalsidase-alfa (PRX-102). However, exposure to PEG via life-style products and vaccination can result in the formation of anti-PEG antibodies. We demonstrate the de novo formation of functional anti-PEG antibodies in a healthy male after the second mRNA-based vaccination against SARS-CoV-2. Consequently, we analyzed the frequency and inhibitory function of...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Collective aeromedical evacuations of SARS-CoV-2-related ARDS patients in a military tactical plane: a retrospective descriptive study
After the appearance of the COVID-19 pandemic in France, MEROPE system was created to transform the military tactical ATLAS A400M aircraft into a flying intensive care unit. Collective aeromedical evacuations (aero-MEDEVAC) of patients suffering from SARS-CoV-2-related acute respiratory distress syndrome was performed from June to December 2020. A total of 22 patients were transported during seven missions. All aero-MEDEVAC was performed in safe conditions for patients and crew. No life-threatening conditions occurred during flight. Biohazard controls were applied according to French guidelines and prevented crew contamina...
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Martinez, T., Simon, K., Lely, L., Nguyen Dac, C., Lefevre, M., Aloird, P., Leschiera, J., Strehaiano, S., Nespoulous, O., Boutonnet, M., Raynaud, L. Tags: COVID-19 Personal view Source Type: research
How Wastewater Testing Can Help Tackle America ’ s Opioid Crisis
Among the many lasting legacies of COVID-19 may be a newfound appreciation for the value of what we flush down the toilet and wash down the drain.
Wastewater can be a rich source of information about infectious diseases, like COVID-19, as well as flu, respiratory syncytial virus (RSV), mpox and polio, since pathogens like viruses are shed in feces, urine and saliva, all of which is drained into sewage treatment plants. Sampling that water is a good way to screen for certain viruses, and, as more people bypass the medical system and labs in favor of testing themselves at home for things like COVID-19, health agencies lik...
Source: TIME: Health - September 21, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news
Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research
Design and Implementation of a National Program to Monitor the Prevalence of SARS-CoV-2 IgG Antibodies in England Using Self-Testing: The REACT-2 Study
Am J Public Health. 2023 Sep 21:e1-e9. doi: 10.2105/AJPH.2023.307381. Online ahead of print.ABSTRACTData System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28...
Source: Am J Public Health - September 21, 2023 Category: International Medicine & Public Health Authors: Helen Ward Christina Atchison Matthew Whitaker Bethan Davies Deborah Ashby Ara Darzi Marc Chadeau-Hyam Steven Riley Christl A Donnelly Wendy Barclay Graham S Cooke Paul Elliott Source Type: research
Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(ii), Co(ii) and Ni(ii) complexes - combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CL < sup > Pro < /sup >
RSC Med Chem. 2023 Jan 3;14(9):1667-1697. doi: 10.1039/d2md00394e. eCollection 2023 Sep 19.ABSTRACTA novel class of bioactive complexes (1-3) [MII(L)2(bpy)], where, L = 2-(4-morpholinobenzylideneamino)phenol, bpy = 2,2'-bipyridine, MII = Mn (1), Co (2) or Ni (3), were assigned to octahedral geometry based on analytical and spectral measurements. Gel electrophoresis showed that complex (2) demonstrated significant DNA cleavage activity compared to the other complexes under the action of oxidation agent (H2O2). The DNA binding constant properties measured by various techniques were in the following sequence: (2) > (3) >...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Karunganathan Sakthikumar Bienfait Kabuyaya Isamura Rui Werner Ma çedo Krause Source Type: research
Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
ConclusionSensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus.PMID:37733239 | DOI:10.2807/1560-7917.ES.2023.28.38.2200938
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Tom áš Kliegr Ji ří Jarkovský Helena Ji řincová Jaroslav Kucha ř Tom áš Karel David Chud án Stanislav Voj íř Michal Zav řel Ond řej Šanca Ruth Tachezy Source Type: research
Surveillance of SARS-CoV-2 infection based on self-administered swabs, Denmark, May to July 2022: evaluation of a pilot study
ConclusionParticipants successfully performed self-swabs and answered symptom questionnaires. Also, WGS analysis of samples was possible. The system can support surveillance of respiratory pathogens and also holds potential as a diagnostic tool, easing access to test for at-risk groups, while also reducing the burden on healthcare system resources.PMID:37733236 | DOI:10.2807/1560-7917.ES.2023.28.38.2200907
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Kamille Fogh Tine Graakj ær Larsen Cyril Jean-Marie Martel Frederik Trier M øller Lasse Skafte Vestergaard Ramona Trebbien Anne-Marie Vangsted Tyra Grove Krause Source Type: research
Design and Implementation of a National Program to Monitor the Prevalence of SARS-CoV-2 IgG Antibodies in England Using Self-Testing: The REACT-2 Study
Am J Public Health. 2023 Sep 21:e1-e9. doi: 10.2105/AJPH.2023.307381. Online ahead of print.ABSTRACTData System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28...
Source: American Journal of Public Health - September 21, 2023 Category: International Medicine & Public Health Authors: Helen Ward Christina Atchison Matthew Whitaker Bethan Davies Deborah Ashby Ara Darzi Marc Chadeau-Hyam Steven Riley Christl A Donnelly Wendy Barclay Graham S Cooke Paul Elliott Source Type: research
Evaluation of concentration procedures, sample pre-treatment, and storage condition for the detection of SARS-CoV-2 in wastewater
Environ Sci Pollut Res Int. 2023 Sep 21. doi: 10.1007/s11356-023-29696-y. Online ahead of print.ABSTRACTCrucial information on the pandemic's spread has been gathered by monitoring the trend of SARS-CoV-2 in wastewater. This surveillance has highlighted that the initial concentration is a critical step of the analytical procedure due to the low viral titer that may be present in this matrix. This paper presents the results of the evaluation of two different wastewater concentration protocols to determine the most efficient and cost-effective. The two methods tested were the following: (a) a biphasic separation system with ...
Source: Environmental Science and Pollution Research International - September 21, 2023 Category: Environmental Health Authors: Francesca Cutrupi Michele Rossi Maria Cadonna Elisa Poznanski Serena Manara Mattia Postinghel Giulia Palumbi Marta Bellisomi Elena Nicosia Giorgia Allaria Lorenzo Dondero Carolina Veneri Pamela Mancini Giusy Bonanno Ferraro Giuseppina Rosa Elisabetta Suff Source Type: research
Recent Advances in Metagenomic Approaches, Applications, and Challenge
Curr Microbiol. 2023 Sep 21;80(11):347. doi: 10.1007/s00284-023-03451-5.ABSTRACTAdvances in metagenomics analysis with the advent of next-generation sequencing have extended our knowledge of microbial communities as compared to conventional techniques providing advanced approach to identify novel and uncultivable microorganisms based on their genetic information derived from a particular environment. Shotgun metagenomics involves investigating the DNA of the entire community without the requirement of PCR amplification. It provides access to study all genes present in the sample. On the other hand, amplicon sequencing targ...
Source: Current Microbiology - September 21, 2023 Category: Microbiology Authors: Niguse K Lema Mesfin T Gemeda Adugna A Woldesemayat Source Type: research
A comparison of 7 commercial anti-SARS-CoV-2 antibody immunoassays
CONCLUSIONS: The results obtained in this study provide evidence for high overall concordance between the comparative CLIA method and different LFIAs. This could justify the use of LFIAs in some settings, where automated assays are not available, provided that some limitations are considered.PMID:37732068 | PMC:PMC10507786 | DOI:10.5114/aoms.2020.98361
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Jakub Swad źba Maciej Bednarczyk Tomasz Anyszek Emilia Martin Source Type: research
Nanoparticles: a breakthrough in COVID-19 prevention, diagnosis and treatment
Arch Med Sci. 2021 Oct 15;19(5):1410-1420. doi: 10.5114/aoms/142103. eCollection 2023.ABSTRACTCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), declared a global pandemic by the World Health Organization (WHO). The three key principles in management of the COVID-19 pandemic are prevention, early detection and targeted treatment. Vaccine-based prevention together with early detection has already proven its efficacy in controlling the pandemic. Early detection of infected patients could substantially accelerate the implementation of treatment,...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Aleksandra Skwarek Aleksandra G ąsecka Mi łosz J Jaguszewski Łukasz Szarpak Tomasz Dzieci ątkowski Krzysztof J Filipiak Source Type: research
Reduction of lymphocyte count at early stage elevates severity and death risk of COVID-19 patients: a hospital-based case-cohort study
CONCLUSIONS: Older COVID-19 patients are more susceptible to lymphopenia. Multiple organ injuries were more serious in COVID-19 patients with lymphopenia. Lymphopenia at an early stage aggravates the severity and elevates the death risk of COVID-19 patients.PMID:37732034 | PMC:PMC10507779 | DOI:10.5114/aoms.2020.99006
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Jun Fei Lin Fu Ying Li Hui-Xian Xiang Ying Xiang Meng-Die Li Fang-Fang Liu De-Xiang Xu Hui Zhao Source Type: research
Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Arch Med Sci. 2021 Apr 23;19(5):1327-1359. doi: 10.5114/aoms/135703. eCollection 2023.ABSTRACTCOVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system. COVID-19 (coronavirus) and other enveloped viruses including severe acute respiratory syndrome (SARS-CoV-1 of 2002-2003) and Middle East respiratory syndrome (MERS; 2012-ongoing) and hepatitis B and C (HBV and HCV) can be inactivated by AA, γ-linolenic acid (GLA, dihomo-GLA (DGLA), eicosapentaenoic ...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Undurti N Das Source Type: research
