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Condition: Rheumatoid Arthritis
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Total 183 results found since Jan 2013.
BAFF Promotes FLS Activation Through BAFFR-Mediated Non-canonical NF- κB Pathway and the Effects of CP-25
In this study, we aimed to understand the mechanism by which BAFF activates FLS and the effect of CP-25 on FLS function. Therefore, the proliferation and migration abilities of FLS and key proteins on the non-canonical NF- κB pathway were examined. The results showed that compared with the FLS of normal rats/OA patients, the expression of BAFF-R, TRAF2, NIK, p-IKKα, P100, and P52 was higher in the FLS of AA rats/RA patients, while the expression of TRAF3 was lower. And, BAFF promotes FLS activation by activating the non-canonical NF-κB signaling pathway. Meanwhile, BAFFR-siRNA inhibited the proliferation of FLS and the ...
Source: Inflammation - January 16, 2023 Category: Allergy & Immunology Source Type: research
Preparation of Mesoporous Silica Nanocarriers Targeting Glucose-6-Phosphate Isomerase Inhibition and Application in the Treatment of Rheumatoid Arthritis
In conclusion, siG6PI-MSN effectively suppress the proliferation and invasive growth of synovial tissue and improve joint swelling and inflammatory infiltration, thereby preventing joint damage in RA. This carrier may be a new therapeutic measure for RA, with potential social and economic benefits.PMID:36610698 | DOI:10.1093/cei/uxac116
Source: Clinical and Developmental Immunology - January 7, 2023 Category: Allergy & Immunology Authors: Ming Zong Yu Cheng Bei Ye Saige Chen Shanshan Yu Menglei Ding Liu Lu Lieying Fan Source Type: research
Acid sensor ASIC1a induces synovial fibroblast proliferation via Wnt/ β-catenin/c-Myc pathway in rheumatoid arthritis
Int Immunopharmacol. 2022 Oct 21;113(Pt A):109328. doi: 10.1016/j.intimp.2022.109328. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and progressive joint destruction in the middle and late stages. Notably, activated rheumatoid arthritis synovial fibroblasts (RASFs) exhibit tumor-like features, including an increased proliferation rate that largely contributes to pannus formation and joint destruction. Our previous studies have demonstrated that acid-sensing ion channel 1a (ASIC1a) was highly expressed in RASFs, and acidic microenvironment of sy...
Source: International Immunopharmacology - October 24, 2022 Category: Allergy & Immunology Authors: Yayun Xu Zheng Lu Yian Ling Ruirui Hou Jingjing Tao Ge Deng Xiaoling Xu Xuewei Chen Jingjing Ruan Yihao Zhang Xiaoqing Peng Feihu Chen Source Type: research
Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF- α-induced inflammatory activation of synovial fibroblasts
This study identified a novel role of Sulf-2 in TNF-α signaling and the activation of RA synoviocytes, providing the rationale for evaluating the therapeutic targeting of Sulf-2 in preclinical models of RA.PMID:36068294 | DOI:10.1038/s41423-022-00913-x
Source: Cellular and Molecular Immunology - September 6, 2022 Category: Molecular Biology Authors: Ruby J Siegel Anil K Singh Paul M Panipinto Farheen S Shaikh Judy Vinh Sang U Han H Mark Kenney Edward M Schwarz Cynthia S Crowson Sadik A Khuder Basil S Khuder David A Fox Salahuddin Ahmed Source Type: research
Geniposide restricts angiogenesis in experimentary arthritis via inhibiting Dnmt1-mediated PTEN hypermethylation
In this study, human umbilical vein endothelial cells (HUVEC) and adjuvant arthritis (AA) rat models were performed to research in vitro and in vivo. The results showed that GE treatment significantly reduced synovitis and angiogenesis in AA rats, which may be associated with the increased expression of PTEN with GE treatment. Meanwhile, the hypermethylation of PTEN accompanied by the over-expression of DNA methyltransferases (Dnmts) was demonstrated in TNF-α-induced HUVEC and AA rats. Knockdown of Dnmt1 by Dnmt1- siRNA significantly inhibited the tube formation of HUVEC in vitro. GE significantly restricted the angiogene...
Source: International Immunopharmacology - July 31, 2022 Category: Allergy & Immunology Authors: Yanhong Bu Hong Wu Ran Deng Yan Wang Source Type: research
siRNA-based nanotherapeutics as emerging modalities for immune-mediated diseases: A preliminary review
This study will pave the way for new avenues of research into the diagnosis and treatment of IMDs.PMID:35830711 | DOI:10.1002/cbin.11841
Source: Cell Biology International - July 13, 2022 Category: Cytology Authors: Saman Sargazi Rabia Arshad Reza Ghamari Abbas Rahdar Ali Bakhshi Sonia Fathi Karkan Narges Ajalli Muhammad Bilal Ana M D íez-Pascual Source Type: research
BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis
CONCLUSION: In summary, RA-FLSs maintained intracellular redox balance through mitophagy to promote cell survival under hypoxia. The mitophagy of OA-FLSs was too little to maintain the redox balance of mitochondria, resulting in apoptosis. The difference of mitophagy between OA-FLSs and RA-FLSs under hypoxia is mediated by the level of BNIP3 expression.PMID:35690741 | DOI:10.1186/s10020-022-00490-9
Source: Molecular Medicine - June 11, 2022 Category: Molecular Biology Authors: Ran Deng Yan Wang Yanhong Bu Hong Wu Source Type: research
Total Saponins of Radix Clematis Regulate Fibroblast-Like Synoviocyte Proliferation in Rheumatoid Arthritis via the LncRNA OIP5-AS1/MiR-410-3p/Wnt7b Signaling Pathway
In this study, we examined whether the TSC treatment of RA affects the lncRNA OIP5-AS1/miR-410-3p/Wnt7b pathway.MATERIALS AND METHODS: Freund's complete adjuvant was used to create an adjuvant arthritis (AA) rat model with rat synovial cells being harvested and cultured. The experiment comprises a normal group, model group, TSC optimal-dose group, TSC optimal-dose group + lncRNA OIP5-AS1siRNA group, lncRNA OIP5-AS1 siRNA group, and lncRNA OIP5-AS1 siRNA + NC group. MMT was used to screen the optimal concentration of TSC. The level of lncRNA OIP5-AS1, miR-410-3p, Wnt7b, β-catenin, c-Myc, cyclin D1, GSK-3β, and SFRP4 mRNA ...
Source: Evidence-based Complementary and Alternative Medicine - June 7, 2022 Category: Complementary Medicine Authors: Lingyu Pan Yuan Sun Hui Jiang Yan Chen Yeke Jiang Yanquan Han Yongzhong Wang Source Type: research
