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Condition: Diabetes

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Total 206 results found since Jan 2013.

Stroke subtypes and interventional studies for transient ischemic attack.
Authors: Lavallée P, Amarenco P Abstract Transient ischemic attack (TIA) is the most important risk factor for ischemic stroke. The risk is the highest in the first hours after symptom onset, and treatment must be initiated in emergency. In the acute phase, antithrombotic agent is probably the most important treatment, but it is not excluded that lipid-lowering agents and/or antihypertensive drugs are also important. For current guidelines, monotherapy of antiplatelet agent remains the gold standard in emergency. However, most recent data and meta-analysis support a combination therapy of clopidogrel and aspirin. ...
Source: Frontiers of Neurology and Neuroscience - December 2, 2015 Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research

Macrophage –NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes
In this study, we found that the cardiac dysfunction induced by ischemic stroke is more severe in a mouse model of type 2 diabetes. Meanwhile, M1-polarized macrophage in filtration and NLRP3 inflammasome activation increased in the cardiac ventricle after diabetic stroke. Importantly, the NLRP3 inflammasome inhibitor CY-09 restored cardiac function, indicating that the M1-polarized macrophage–NLRP3 inflammasome activation is a pathway underlying the brain–heart interaction after diabetic stroke.
Source: Neuroscience Bulletin - July 17, 2020 Category: Neuroscience Source Type: research

Chronic metformin treatment improves post‐stroke angiogenesis and recovery after experimental stroke
Abstract Metformin is currently the first‐line treatment drug for type 2 diabetes. Metformin is a well‐known activator of AMP‐activated protein kinase (AMPK). In experimental studies, metformin has been shown to exert direct vascular effects by increasing vascular endothelial growth factor expression and improving microvascular density. As stroke is the leading cause of long‐term disability and angiogenesis is implicated as an important mechanism in functional recovery, we hypothesized that chronic metformin treatment would improve post‐stroke functional recovery by enhancing functional microvascular density. For...
Source: European Journal of Neuroscience - March 1, 2014 Category: Neuroscience Authors: Venugopal R. Venna, Jun Li, Matthew D. Hammond, Nickolas S. Mancini, Louise D. McCullough Tags: Research Report Source Type: research

Association between gender and stoke recurrence in ischemic stroke patients with high-grade carotid artery stenosis
In conclusion, male gender is associated with increased risk of recurrent ischemic stroke in patients with high-grade ICA stenosis during 5-year follow-up. Further prospective trial to assess whether male gender may benefit from more aggressive vascular risk factors control and treatment strategies for stroke prevention is warranted.
Source: Journal of Clinical Neuroscience - June 17, 2019 Category: Neuroscience Source Type: research

SNP rs2043211 (p.C10X) in CARD8 Is Associated with Large-Artery Atherosclerosis Stroke in a Chinese Population
This study aimed to explore the possible association between rs2043211 and large-artery atherosclerosis stroke in Chinese and explain the possible mechanism. In total, 716 large-artery atherosclerosis stroke patients and 1088 controls were included in the study. Co-dominant, dominant, and recessive genetic models were constructed to evaluate the relationship between rs2043211 and large-artery atherosclerosis stroke risk by odds ratios with 95% confidence intervals. Stratified and interaction analyses were also done. We selected another 111 large-artery atherosclerosis stroke patients and measured the CARD8 levels in their ...
Source: Journal of Molecular Neuroscience - June 28, 2020 Category: Neuroscience Source Type: research

Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats
Publication date: 2 June 2016 Source:Neuroscience, Volume 324 Author(s): J. Hu, B. Liu, Q. Zhao, P. Jin, F. Hua, Z. Zhang, Y. Liu, K. Zan, G. Cui, X. Ye High-mobility group box 1 (HMGB1), a ligand of receptor for advanced glycation endproducts (RAGE), functions as a proinflammatory factor. It is mainly involved in inflammatory activation and contributes to the initiation and progression of stroke. By using a model of transient middle cerebral artery occlusion (MCAo) in type 2 diabetic rats, we investigated the changes of pro-inflammation mediators, blood–brain barrier (BBB) leakage and functional outcome afte...
Source: Neuroscience - March 13, 2016 Category: Neuroscience Source Type: research

Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats
In conclusion, enhanced expression of Ang1 and Tie2 in ischemic brain after BMSCs-CM treatment of stroke may contribute to the improved functional recovery after stroke in type 2 diabetic rats.
Source: Neuroscience Letters - February 26, 2017 Category: Neuroscience Source Type: research

Impact of microRNAs on ischemic stroke: From pre- to post-disease
Publication date: Available online 24 August 2017 Source:Progress in Neurobiology Author(s): Guangwen Li, Kahlilia C. Morris-Blanco, Mary S. Lopez, Tuo Yang, Haiping Zhao, Raghu Vemuganti, Yumin Luo Stroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttranscriptional...
Source: Progress in Neurobiology - August 25, 2017 Category: Neuroscience Source Type: research

Exosomes from miRNA-126-modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke.
CONCLUSION: Our results indicate that enrichment of miR126 enhanced the therapeutic efficacy of EPC-EXs on diabetic ischemic stroke by attenuating acute injury and promoting neurological function recovery. PMID: 33009888 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - October 2, 2020 Category: Neuroscience Authors: Wang J, Chen S, Zhang W, Chen Y, Bihl JC Tags: CNS Neurosci Ther Source Type: research

Stress hyperglycemia is associated with in-hospital mortality in patients with diabetes and acute ischemic stroke
CONCLUSIONS: The SHR may serve as an accessory parameter for the prognosis of patients with diabetes after acute ischemic stroke. Hyperglycemia in stroke patients with diabetes mellitus is associated with a higher risk of in-hospital death.PMID:35084107 | DOI:10.1111/cns.13764
Source: CNS Neuroscience and Therapeutics - January 27, 2022 Category: Neuroscience Authors: Donghua Mi Zixiao Li Hongqiu Gu Yingyu Jiang Xingquan Zhao Yilong Wang Yongjun Wang Source Type: research

Pre-diabetes, Diabetes, Hyperglycemia, and Stroke: Bittersweet Therapeutic Opportunities
AbstractPurposeof ReviewDiabetes mellitus (DM) causes systemic vascular complications. Chronic hyperglycemia is a hallmark of DM and appears to be at least partially responsible for the vascular complications. In addition, hyperglycemia during acute tissue injury has been postulated to augment the injury. This review addresses the potential therapeutic benefits related to ischemic stroke from lowering hyperglycemia in two settings, in chronic hyperglycemia and during acute ischemic stroke.Recent FindingsA recent efficacy trial to lower hyperglycemia during acute ischemic stroke showed no significant benefit overall as well...
Source: Current Neurology and Neuroscience Reports - October 10, 2022 Category: Neuroscience Source Type: research