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Condition: Diabetes

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Total 1499 results found since Jan 2013.

LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway
This study aims to evaluate underlying mechanisms of ADMA in DCM especially for EndMT under diabetic conditions. A diabetic rat model was induced by streptozotocin (STZ) injection, and human cardiac microvascular endothelial cells (HCMECs) were stimulated with high glucose to induce EndMT. Subsequently, the role of ADMA in EndMT was detected either by exogenous ADMA or by over-expressing dimethylarginine dimethylaminohydrolase 1 (DDAH1, degradation enzyme for ADMA) before high glucose stimulation. Furthermore, the relationships among forkhead box protein O1 (FoxO1), DDAH1 and ADMA were evaluated by FoxO1 over-expression or...
Source: European Journal of Pharmacology - April 28, 2023 Category: Drugs & Pharmacology Authors: Meiting Wu Ting Li Ge Li Bingxuan Niu Tian Wu Li Yan Shiming Wang Shuangyi He Chuyi Huang Weiqiang Tong Niansheng Li Junlin Jiang Source Type: research

Down-regulation of Fas activity rescues early onset of diabetes in c-KitWv/+ mice.
Abstract c-Kit and its ligand, stem cell factor (SCF), are important for β-cell survival and maturation; meanwhile, interactions between the Fas receptor and Fas ligand are capable of triggering β-cell apoptosis. Disruption of c-Kit signaling leads to severe loss of β-cell mass and function with up-regulation of Fas expression in c-Kit(Wv/+) mouse islets, suggesting that there is a critical balance between c-Kit and Fas activation in β-cells. In the present study, we propose to investigate the inter-relationship between c-Kit and Fas activation that mediates β-cell survival and function. We generated double m...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 26, 2012 Category: Physiology Authors: Feng ZC, Riopel M, Li J, Donnelly L, Wang R Tags: Am J Physiol Endocrinol Metab Source Type: research

Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel.
Abstract Metformin, an extensively used and well-tolerated drug for treating individuals with type 2 diabetes, has recently gained significant attention as an anticancer drug. On the other hand, paclitaxel (Taxol) is a new antineoplastic drug that has shown promise in the treatment of non-small cell lung cancer (NSCLC). High expression levels of excision repair cross-complementary 1 (ERCC1) in cancers have been positively associated with the DNA repair capacity and a poor prognosis in NSCLC patients treated with platinum-containing chemotherapy. In this current study, paclitaxel was found to increase phosphorylati...
Source: Biochemical Pharmacology - December 7, 2012 Category: Drugs & Pharmacology Authors: Tseng SC, Huang YC, Chen HJ, Chiu HC, Huang YJ, Wo TY, Weng SH, Lin YW Tags: Biochem Pharmacol Source Type: research

Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway
Conclusion: Culture of MMCs in the presence of HG up-regulates expression of Gremlin. Gremlin induces cell proliferation and accumulation of ECM in MMCs. and enhances activation of the ERK1/2 pathway.
Source: BMC Nephrology - February 11, 2013 Category: Urology & Nephrology Authors: Haixia HuangHaiying HuangYing LiMaodong LiuYonghong ShiYanqing ChiTao Zhang Source Type: research

Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91.
Abstract Recent research using a rat oxygen-induced retinopathy model has demonstrated that the G protein-coupled receptor 91 (GPR91) of retinal ganglion neurons is the principal respondent to succinate and consequently induces the release of angiogenic factor vascular endothelial growth factor (VEGF). The aim of this study was to determine whether GPR91 modulate the release of VEGF from retinal ganglion cells in a high-glucose model in vitro and to dissect the role of GPR91 in the pathogenesis of diabetic retinopathy. We constructed a lentiviral small hairpin RNA (shRNA) expression vector targeting GPR91 (LV.shGP...
Source: Experimental Eye Research - February 1, 2013 Category: Opthalmology Authors: Hu J, Wu Q, Li T, Chen Y, Wang S Tags: Exp Eye Res Source Type: research

A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced ER stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated IL-6 generation.
Abstract We studied the protective effect of stromal cell-derived factor-1beta (SDF-1β) on cardiac cells from lipotoxicity in vitro and diabetes in vivo. Exposure of cardiac cells to palmitate increased apoptosis by activating NADPH oxidase-associated nitrosative stress and endoplasmic reticulum (ER) stress, which abolished by pretreatment with SDF-1β via up-regulation of AMPK-mediated p38 MAPK phosphorylation and IL-6 production. The SDF-1β cardiac protection could be abolished by inhibition of AMPK, p38 MAPK or IL-6. Activation of AMPK or addition of recombinant IL-6 recaptured a similar cardiac protection. S...
Source: Diabetes - February 19, 2013 Category: Endocrinology Authors: Zhao Y, Tan Y, Xi S, Li Y, Li C, Cui J, Yan X, Li X, Wang G, Li W, Cai L Tags: Diabetes Source Type: research

Regulation of matrix metallopeptidase-9 by epigenetic modifications, and the development of diabetic retinopathy.
Abstract Diabetes activates retinal matrix metallopeptidase-9 (MMP-9), and MMP-9 damages the mitochondria and augments capillary cell apoptosis. Our aim is to elucidate the mechanism responsible for MMP-9 activation. Histone modifications and recruitment of the transcriptional factor NF-kB (p65 subunit) at MMP-9 promoter and the activity of lysine-specific demethylase 1 (LSD1) were measured in the retina from streptozotocin-induced diabetic rats. The role of LSD1 in MMP-9 activation was investigated in isolated retinal endothelial cells transfected with LSD1-siRNA. The results were confirmed in the retina from hum...
Source: Diabetes - February 19, 2013 Category: Endocrinology Authors: Zhong Q, Kowluru RA Tags: Diabetes Source Type: research

Downregulation of Fas activity rescues early onset of diabetes in c-KitWv/+ mice
c-Kit and its ligand stem cell factor (SCF) are important for β-cell survival and maturation; meanwhile, interactions between the Fas receptor (Fas) and Fas ligand are capable of triggering β-cell apoptosis. Disruption of c-Kit signaling leads to severe loss of β-cell mass and function with upregulation of Fas expression in c-KitWv/+ mouse islets, suggesting that there is a critical balance between c-Kit and Fas activation in β-cells. In the present study, we investigated the interrelationship between c-Kit and Fas activation that mediates β-cell survival and function. We generated double mutant, c...
Source: AJP: Endocrinology and Metabolism - March 15, 2013 Category: Endocrinology Authors: Feng, Z.-C., Riopel, M., Li, J., Donnelly, L., Wang, R. Tags: Articles Source Type: research

High Glucose-Induced Downregulation of Connexin 30.2 Promotes Retinal Vascular Lesions: Implications for Diabetic Retinopathy Retinal Cell Biology
Conclusions. These results indicate that HG- or diabetes-induced downregulation of Cx30.2 expression and decrease in GJIC activity play a critical role in the development of retinal vascular lesions in early DR.
Source: Investigative Ophthalmology - March 28, 2013 Category: Opthalmology Authors: Manasson, J., Tien, T., Moore, C., Kumar, N. M., Roy, S. Tags: Retinal Cell Biology Source Type: research

A Key Role for ROCK in TNF-{alpha}-Mediated Diabetic Microvascular Damage Retinal Cell Biology
Conclusions. ROCK is a key mediator of TNF-α signaling in diabetic microvessels. The important role of TNF-α in early DR provides a new rationale for ROCK inhibition beyond the previously shown mechanisms.
Source: Investigative Ophthalmology - March 28, 2013 Category: Opthalmology Authors: Arita, R., Nakao, S., Kita, T., Kawahara, S., Asato, R., Yoshida, S., Enaida, H., Hafezi-Moghadam, A., Ishibashi, T. Tags: Retinal Cell Biology Source Type: research

Effect of endogenous insulin-like growth factor and stem cell factor on diabetic colonic dysmotility.
CONCLUSION: Myopathy may resolve in colonic motility dysfunction in diabetic rats. Deficiency of endogenous IGF-1 in colonic smooth muscle cells leads to reduction of SCF expression. PMID: 23745035 [PubMed - in process]
Source: World Journal of Gastroenterology - June 7, 2013 Category: Gastroenterology Authors: Wang Y, Xu XY, Tang YR, Yang WW, Yuan YF, Ning YJ, Yu YJ, Lin L Tags: World J Gastroenterol Source Type: research

Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation.
Conclusion:DML effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders. PMID: 23852084 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - July 15, 2013 Category: Drugs & Pharmacology Authors: Zhou R, Lin ZH, Jiang CS, Gong JX, Chen LL, Guo YW, Shen X Tags: Acta Pharmacol Sin Source Type: research

Upregulation of Glutamate-Aspartate Transporter by Glial Cell Line-Derived Neurotrophic Factor Ameliorates Cell Apoptosis in Neural Retina in Streptozotocin-Induced Diabetic Rats.
CONCLUSIONS: GDNF, administrated at the early stage of diabetes, could rescue retinal cells from neurodegeneration by upregulating the expression of GLAST. PMID: 23870489 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - July 22, 2013 Category: Neuroscience Authors: Wang L, Deng QQ, Wu XH, Yu J, Yang XL, Zhong YM Tags: CNS Neurosci Ther Source Type: research

Nrf2 Modulates Contractile and Metabolic Properties of Skeletal Muscle in Streptozotocin-Induced Diabetic Atrophy.
Abstract The role of Nrf2 in disease prevention and treatment is well documented, however the specific role of Nrf2 in skeletal muscle is not well described. The current study investigated whether Nrf2 plays a protective role in an STZ-induced model of skeletal muscle atrophy. Modulation of Nrf2 through siRNA resulted in a more robust differentiation of C2C12s, whereas increasing Nrf2 with sulforaphane treatment inhibited differentiation. Diabetic muscle atrophy was not dramatically influenced by Nrf2 genotype, since no differences were observed in total atrophy (all fiber types combined) between WT+STZ and KO+STZ...
Source: Experimental Cell Research - July 26, 2013 Category: Cytology Authors: Whitman SA, Long M, Wondrak G, Zheng H, Zhang DD Tags: Exp Cell Res Source Type: research