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Condition: Diabetes
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Total 183768 results found since Jan 2013.
Tirzepatide Tops Semaglutide for A1c Control, Weight Loss Tirzepatide Tops Semaglutide for A1c Control, Weight Loss
A meta-analysis of studies on the two diabetes drugs shows stronger benefits with tirzepatide, with the caveat of some higher gastrointestinal effects with tirzepatide.Medscape Medical News
Source: Medscape Diabetes Headlines - September 23, 2023 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Are Vitamin D Levels Key to Canagliflozin ' s Fracture Risk? Are Vitamin D Levels Key to Canagliflozin ' s Fracture Risk?
Study findings suggest that patients be screened for vitamin D deficiency before starting SGLT2 inhibitor therapy, or they should simply be prescribed vitamin D supplements.Medscape Medical News
Source: Medscape Diabetes Headlines - September 22, 2023 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Prenatal Care Utilization Challenges and Facilitators for a Growing Latino Community in the Midwest
Conclusions for PracticeResults from this study highlight important targets to improve PNC for Latina women. Participants called for various types of support to address identified challenges, ranging from information on social media about PNC services to broader efforts such as building trust from the community toward PNC providers and making PNC services affordable for women with gestational diabetes.
Source: Maternal and Child Health Journal - September 22, 2023 Category: Health Management Source Type: research
Dipeptidyl-peptidase-4 inhibitors have anti-inflammatory effects in patients with type 2 diabetes
ConclusionThis meta-analysis demonstrated that DPP-4 inhibitors can significantly attenuate low-grade inflammatory state in patients with T2DM. In addition to improving glycemic control, DDP-4 inhibitors might offer extra therapeutic value by controlling inflammation.Graphical Abstract
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
Impact of tofogliflozin on hepatic outcomes: a systematic review
ConclusionOverall, an improvement in levels of hepatic parameters was observed in T2DM patients with concurrent liver disorders. However, a large number of clinical trials are needed to prove the efficacy of tofogliflozin on hepatic outcomes in patients with T2DM.
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
New insights on the potential anti-epileptic effect of metformin: Mechanistic pathway
In conclusion, metformin might be an adjuvant with AEAs in the management of refractory epilepsy. Preclinical and clinical studies are warranted in this regard.PMID:37737447 | DOI:10.1111/jcmm.17965
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Saud A Alnaaim Hayder M Al-Kuraishy Ali I Al-Gareeb Naif H Ali Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research
Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells
In this study, we investigated the role of STIM1 in the proliferation and fibrosis in high glucose (HG)-induced HBZY-1 cells. We found that the expression of STIM1 was increased in renal tissues of diabetic rat and HBZY-1 cells stimulated by HG. Downregulation of STIM1-mediated SOCE suppressed hyperglycemic cell proliferation and fibrosis by activating autophagy. In addition, the inhibitory effect of downregulating STIM1 on cells was blocked by autophagy inhibitor Bafilomycin A1 (BafA1). Moreover, this experiment also showed that STIM1 regulated autophagy, cell proliferation and fibrosis via PI3K/AKT/mTOR signal pathway. T...
Source: Molecular and Cellular Biochemistry - September 22, 2023 Category: Biochemistry Authors: Xixi Zeng Anbang Sun Weiyi Cheng Xin Hou Min Zhu Yanhong Liao Source Type: research
Fetal Exposure to Preeclampsia and Later Risk of Cardiometabolic Disorders: A Population-Based Cohort Study
CONCLUSIONS: Fetal preeclampsia exposure was associated with adult life hypertension, diabetes, and dyslipidemia, but these associations were likely due to shared etiological factors, rather than exposure to the preeclamptic condition itself.PMID:37737002 | DOI:10.1161/HYPERTENSIONAHA.122.20682
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Abira Paramsothy Tor-Arne Hegvik Anders Engeland Tone Bj ørge Grace M Egeland Kari Klungs øyr Source Type: research
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
Conclusions: High resolution chromatin interaction profiles at selectively targeted loci can complement genome- and promoter-wide maps.PMID:37736013 | PMC:PMC10509606 | DOI:10.12688/wellcomeopenres.18653.2
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jason M Torres Han Sun Vibe Nylander Damien J Downes Martijn van de Bunt Mark I McCarthy Jim R Hughes Anna L Gloyn Source Type: research
Designing Stimuli-Responsive Upconversion Nanoparticles Based on a Mimetic Immunoassay for Potential Diabetic Nephropathy Accuracy Diagnosis
Analyst, 2023, Accepted Manuscript DOI: 10.1039/D3AN01041D, PaperYiting Wang, Yang Hu, Ru Wang, Wei Zhang, Huiting Mao, Chuanjun Yuan, Ruinian Hua Diabetic nephropathy (DN) is the most common microvascular complication associated with incurable diabetes. The gold standard diagnostic method for DN is based on the detection of proteinuria but it overlooks... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - September 22, 2023 Category: Chemistry Authors: Yiting Wang Source Type: research
FDA Panel Rejects Implanted GLP1-RA-Dosing Device for T2D FDA Panel Rejects Implanted GLP1-RA-Dosing Device for T2D
An implanted device for delivering the GLP-1 receptor agonist exenatide to people with type 2 diabetes received a unanimous no vote from an FDA advisory panel based on safety and other concerns.Medscape Medical News
Source: Medscape Diabetes Headlines - September 22, 2023 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Echocardiography Boosts Prognostic Power in T1D Echocardiography Boosts Prognostic Power in T1D
Myocardial performance index, a heart-function metric derived from echo findings, significantly boosted the ability to predict incident CVD, especially heart failure, in people with type 1 diabetes.Medscape Medical News
Source: Medscape Cardiology Headlines - September 22, 2023 Category: Cardiology Tags: Cardiology News Source Type: news
Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study
ConclusionThis study provides MR evidence supporting causal associations of many modifiable risk factors with kidney stones. Sedentary lifestyles, obesity, smoking, and T2DM are mediating factors in the causal relationship between educational attainment and kidney stones. Our results suggest more attention should be paid to these modifiable factors to prevent kidney stones.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research
Practice of complementary and alternative medicine use in North Indian children with type 1 diabetes: an exploratory study
ConclusionCAM, mostly herbal, is frequently used among children with T1DM in North India and has detrimental effects on glycemic control. This information should be used during diabetes education to avoid medical emergencies related to sub-optimal insulin dosing.
Source: Diabetology International - September 22, 2023 Category: Endocrinology Source Type: research
