• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Mendelian randomization study of the effect of coronary artery calcification on atherosclerotic cardiovascular diseases
In this study, we used Mendelian randomization (MR) to systematically investigate the causal role of CAC across a broad range of atherosclerotic cardiovascular diseases including coronary heart disease, angina, MI, ischemic heart disease, stroke, and peripheral vascular disease. Publicly available data from the UK biobank and other data sources were used. Using the two-sample Mendelian randomization (MR) approach, we applied 3 MR models including the inverse variance weighted, the weighted-median, and the weighted-mode methods. Eight SNPs associated with CAC were selected as instrumental variables. We observed causal evide...
Source: Atherosclerosis - September 1, 2022 Category: Cardiology Authors: Wichanon Sae-Jie Tarinee Tangcharoen Prin Vathesatogkit Wichai Aekplakorn Pimphen Charoen Source Type: research

Coronary artery calcifications and 6-month mortality in patients with COVID-19 without known atheromatous disease
CONCLUSIONS: Non-electrocardiogram-gated computed tomography during the initial pulmonary assessment of patients with COVID-19 without atherosclerotic cardiovascular disease showed a high prevalence of mild, moderate and heavy CAC. CAC score was related to 6-month mortality, independent of conventional cardiovascular risk factors. These results highlight the importance of CAC scoring for patients hospitalized with COVID-19, and calls for attention to patients with high CAC.PMID:35305915 | DOI:10.1016/j.acvd.2022.02.007
Source: Archives of Cardiovascular Diseases - March 20, 2022 Category: Cardiology Authors: Anne-Sophie Le Hir Antoine Fayol Elie Mousseaux Nicolas Danchin Victoria Tea Chekrallah Chamandi Gilles Soulat Etienne Puymirat Source Type: research

Risk of Cardiovascular Conditions in Patients with Chronic Hypoparathyroidism: A Retrospective Cohort Study
ConclusionsThis large retrospective cohort study showed that chronic hypoparathyroidism was associated with increased risk of incident cardiovascular conditions and arrhythmias. Results should be evaluated in light of limitations inherent to claims database analyses. Further studies are warranted to investigate reasons for these risks and to develop strategies for reducing cardiovascular conditions in patients with chronic hypoparathyroidism.
Source: Advances in Therapy - June 24, 2021 Category: Drugs & Pharmacology Source Type: research

Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis
AbstractThe role of dietary calcium in cardiovascular disease prevention is unclear. We aimed to determine the association between calcium intake and incident cardiovascular disease and mortality. Data were extracted from the European Prospective Investigation of Cancer, Norfolk (EPIC-Norfolk). Multivariable Cox regressions analysed associations between calcium intake (dietary and supplemental) and cardiovascular disease (myocardial infarction, stroke, heart failure, aortic stenosis, peripheral vascular disease) and mortality (cardiovascular and all-cause). The results of this study were pooled with those from published pr...
Source: European Journal of Epidemiology - December 31, 2020 Category: Epidemiology Source Type: research

Coronary Calcium Score for the Prediction of Asymptomatic Coronary Artery Disease in Patients With Ischemic Stroke
Conclusion: The necessity for CAC evaluation could be determined based on the presence of risk factors and significant stenosis of the cervicocephalic arteries. CAC evaluation may be useful for screening for severe CAD in stroke patients.
Source: Frontiers in Neurology - March 26, 2020 Category: Neurology Source Type: research

High androgens in postmenopausal women and the risk for atherosclerosis and cardiovascular disease: the Rotterdam Study.
Conclusion: Postmenopausal high androgen levels were not associated with an increased risk for CVD. Cardiovascular health in women with PCOS might be better than was anticipated. PMID: 29408955 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 1, 2018 Category: Endocrinology Authors: Meun C, Franco OH, Dhana K, Jaspers L, Muka T, Louwers Y, Ikram MA, Fauser BCJM, Kavousi M, Laven JSE Tags: J Clin Endocrinol Metab Source Type: research

Plaque Composition in the Proximal Superficial Femoral Artery and Peripheral Artery Disease Events
Conclusions Among patients with PAD, LRNC in the SFA was associated with higher rates of clinical PAD events, and this association was independent of ABI. Further study is needed to determine whether interventions that reduce SFA LRNC prevent PAD events.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - September 4, 2017 Category: Radiology Authors: McDermott, M. M., Kramer, C. M., Tian, L., Carr, J., Guralnik, J. M., Polonsky, T., Carroll, T., Kibbe, M., Criqui, M. H., Ferrucci, L., Zhao, L., Hippe, D. S., Wilkins, J., Xu, D., Liao, Y., McCarthy, W., Yuan, C. Tags: Original Research Source Type: research

Association of Cardiovascular Health With Subclinical Disease and Incident Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology
ConclusionsThere is a graded inverse association between CVH scores and measures of subclinical and overt cardiovascular disease that is similar across race/ethnic groups.
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Polonsky, T. S., Ning, H., Daviglus, M. L., Liu, K., Burke, G. L., Cushman, M., Eng, J., Folsom, A. R., Lutsey, P. L., Nettleton, J. A., Post, W. S., Sacco, R. L., Szklo, M., Lloyd-Jones, D. M. Tags: Epidemiology, Lifestyle, Primary Prevention, Race and Ethnicity, Vascular Disease Original Research Source Type: research

Subclinical Atherosclerosis Measures for Cardiovascular Prediction in CKD
In conclusion, each measure improved cardiovascular risk prediction in subjects with CKD, with the greatest improvement observed with coronary artery calcium score.
Source: Journal of the American Society of Nephrology : JASN - January 30, 2015 Category: Urology & Nephrology Authors: Matsushita, K., Sang, Y., Ballew, S. H., Shlipak, M., Katz, R., Rosas, S. E., Peralta, C. A., Woodward, M., Kramer, H. J., Jacobs, D. R., Sarnak, M. J., Coresh, J. Tags: Clinical Epidemiology Source Type: research

Are Carotid Artery Stenosis-Isolated and Carotid Artery-Plus Two Distinct Entities? (P7.172)
CONCLUSIONS: CAS-isolated and CAS-plus appear to be two distinct entities with unique demographic and clinical attributes.Disclosure: Dr. Jani has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Jani, V., Malik, A., Hussain, S., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease Source Type: research

Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study: Objectives, Methods, and Cohort Description
ConclusionsThe MASALA study will provide novel data on the prevalence and associations of cardiovascular risk factors and subclinical atherosclerosis in South Asians living in the United States.
Source: Clinical Cardiology - November 5, 2013 Category: Cardiology Authors: Alka M. Kanaya, Namratha Kandula, David Herrington, Matthew J. Budoff, Stephen Hulley, Eric Vittinghoff, Kiang Liu Tags: Trial Design Source Type: research

Mortality and Morbidity During and After Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: Results by Sex Clinical Trial - ALLHAT
To determine whether an angiotensin-converting enzyme inhibitor (lisinopril) or calcium channel blocker (amlodipine) is superior to a diuretic (chlorthalidone) in reducing cardiovascular disease incidence in sex subgroups, we carried out a prespecified subgroup analysis of 15 638 women and 17 719 men in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Total follow-up (active treatment + passive surveillance using national administrative databases to ascertain deaths and hospitalizations) was 8 to 13 years. The primary outcome was fatal coronary heart disease or nonfatal myocardial i...
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Oparil, S., Davis, B. R., Cushman, W. C., Ford, C. E., Furberg, C. D., Habib, G. B., Haywood, L. J., Margolis, K., Probstfield, J. L., Whelton, P. K., Wright, J. T., for the ALLHAT Collaborative Research Group Tags: Primary prevention, Secondary prevention, Clinical Studies Clinical Trial - ALLHAT Source Type: research