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Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt
Conclusion We have shown that SCD subjects are much more likely than non-SCD subjects to have impaired cardiac, but intact peripheral responses to orthostatic stress induced by HUT. These abnormal responses are associated with low baseline cardiac parasympathetic activity, independent of hemoglobin level. The classification of autonomic phenotypes based on HUT response may have potential use for predicting disease severity, guiding and targeting treatments/interventions to alleviate the risk of adverse outcomes in SCD. Ethics Statement All experiments were conducted at Children’s Hospital Los Angeles (CHLA). The ...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

Self-reported sleep problems and incidence of dementia (P2.173)
CONCLUSIONS: Our results suggest that increased daytime sleepiness is independent risk factor for dementia in older adults. Study Supported by: WHICAP grant numer:R01AG037212, Felloship in memory of 'Maria Zaousi'Disclosure: Dr. Tsapanou has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Scarmeas has received personal compensation for activities with Novartis. Dr. Stern has received personal compensation for activities with Elan, Bayer Pharmaceuticals Corporation, Cephalon, and GalaxoSmithKlein as a consultant.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Tsapanou, A., Gu, Y., Scarmeas, N., Stern, Y. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Memory, Olfaction, and Alzheimer ' s Disease Risk Factors Source Type: research

Smoking status, clinical presentation and outcomes in obstructive sleep apnoea
Conclusions. Smoking habits seems to be associated with the severity of OSA and CVS outcomes. These results underline the importance of smoking cessation in the treatment of patients with OSA.Supported by ISCIII grant PI12/02175, SADAR/2013 and SEPAR/2013.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Boldova, A., Carrizo, S., Minchole, E., Moya, V., Forcen, E., Marin, J. M. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Why Every Woman Needs A Good Night's Rest
When I began writing in this spot three years ago, the headline of my very first entry was, "Getting Enough Sleep Is Smart, Not Selfish." That post went up at a time when Americans were beginning to focus more on a good night's rest. The subject came into a sharper focus, in part, because wearable technology gave us some specifics. Forget the anecdotal evidence of whether we slept well; with the touch of a button, we could know what time we fell asleep, how long we were out and how often our sleep was interrupted. The study of sleep -- and conversations around it -- began gaining traction. Among those paying keen attenti...
Source: Healthy Living - The Huffington Post - July 11, 2016 Category: Consumer Health News Source Type: news

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research