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Condition: Sickle Cell Anemia
Countries: India Health

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Total 18 results found since Jan 2013.

β(S) globin gene haplotype and the stroke risk among Egyptian children with sickle cell disease.
CONCLUSION: This study provides a relevant contribution to our understanding of the anthropological and historical background of the population in Egypt where Benin haplotype is the commonest β(S) globin gene haplotype and homozygous Benin/Benin is associated with higher stroke risk than other haplotypes. PMID: 29157167 [PubMed - as supplied by publisher]
Source: Hematology - November 23, 2017 Category: Hematology Tags: Hematology Source Type: research

Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial
Blood Adv. 2023 Feb 3:bloodadvances.2022008539. doi: 10.1182/bloodadvances.2022008539. Online ahead of print.ABSTRACTData from small clinical trials in the USA and India suggest zinc supplementation reduces infection in adolescents and adults with sickle cell anemia (SCA), but no studies of zinc supplementation for infection prevention have been conducted in young children with SCA living in Africa, who have higher infection rates. We conducted a randomized double-blind placebo-controlled trial to assess the effectiveness of zinc supplementation for prevention of severe or invasive infections in Ugandan children 1.00-4.99 ...
Source: Adv Data - February 3, 2023 Category: Epidemiology Authors: Ruth Namazzi Robert O Opoka Andrea L Conroy Dibyadyuti Datta Abner Tagoola Caitlin Bond Michael J Goings Moon-Suhn Ryu Sarah E Cusick Nancy F Krebs Jeong Hoon Jang Wanzhu F Tu Russell E Ware Chandy C John Source Type: research

Evolving locally appropriate models of care for indian sickle cell disease.
Abstract The sickle cell gene in India represents a separate occurrence of the HbS mutations from those in Africa. Sickle cell disease in India occurs against different genetic and environmental backgrounds from those seen in African patients and there is evidence of clinical differences between the populations. Knowledge of the clinical features of African disease was drawn from the Jamaican Cohort Study, based on prospective follow up of all cases of sickle cell disease detected by the screening of 100,000 consecutive newborns in Kingston, Jamaica, and supplemented by observations from the Cooperative Study of S...
Source: Indian J Med Res - March 31, 2016 Category: Research Authors: Serjeant GR Tags: Indian J Med Res Source Type: research

Clinical manifestations of sickle cell disease in India: misconceptions and reality
Purpose of review In the past, milder clinical manifestations of sickle cell disease (SCD) have been described from India. However, recent data from some parts of India suggest that the severity of the disease can be compared to that of African phenotypes. This review therefore describes the varied clinical manifestation of SCD, the success of newborn screening programme, prenatal diagnosis and low dose hydroxyurea therapy in India. Recent findings The varied clinical manifestations such as anemia, vaso-occlusive crisis, acute chest syndrome, renal involvement, stroke and so on vary from one part of the country to the...
Source: Current Opinion in Hematology - April 5, 2018 Category: Hematology Tags: ERYTHROID SYSTEM AND ITS DISEASES: Edited by Narla Mohandas Source Type: research

Sickle cell disease: Transslating clinical care to low-resource countries through international research collaborations
The vast majority of the world ′s population of children and adults with sickle cell disease (SCD) are born in low-resource settings, particularly in sub-Saharan Africa, the Caribbean, the Middle East, and India. As a result numerous well-established, cost-effective, and evidence-based strategies for managing SCD such as newbor n screening, early education, vaccinations, screening for stroke prevention, and treatments with safe transfusions and hydroxyurea are often unavailable, leading to substantial morbidity and increased mortality.
Source: Seminars in Hematology - April 25, 2018 Category: Hematology Authors: Luke R. Smart, Arielle G. Hernandez, Russell E. Ware Source Type: research

Sickle cell disease: Translating clinical care to low-resource countries through international research collaborations
The vast majority of the world ’s population of children and adults with sickle cell disease (SCD) are born in low-resource settings, particularly in sub-Saharan Africa, the Caribbean, the Middle East, and India. As a result numerous well-established, cost-effective, and evidence-based strategies for managing SCD such as newbor n screening, early education, vaccinations, screening for stroke prevention, and treatments with safe transfusions and hydroxyurea are often unavailable, leading to substantial morbidity and increased mortality.
Source: Seminars in Hematology - April 25, 2018 Category: Hematology Authors: Luke R. Smart, Arielle G. Hernandez, Russell E. Ware Tags: Review article Source Type: research

Asymmetric Dimethylarginine Levels and Its Correlation to Cerebral Blood Flow in Children with Sickle Cell Anemia
AbstractAsymmetric dimethylarginine (ADMA) level may play a role in the pathogenesis of cerebrovascular stroke in Children with Sickle Cell Anemia (SCA). To assess the plasma level of ADMA in children with SCA and its correlation to cerebral blood flow. This is a cross sectional study was carried out on 30 children with homozygous SCA under follow up in the Out Patients Clinic, Pediatric Department at Tanta University Hospital and 30 healthy children as a control group. Both groups had undergone the following investigations: Complete blood count, lactate dehydrogenase enzyme, and plasma level of ADMA by a commercial ADMA E...
Source: Indian Journal of Hematology and Blood Transfusion - March 12, 2019 Category: Hematology Source Type: research

Association of plasma homocysteine level with vaso-occlusive crisis in sickle cell anemia patients of Odisha, India
AbstractVascular complications of sickle cell anemia (SCA) are influenced by many factors. Elevated plasma homocysteine (Hcy) is supposed to be an independent risk factor and is either genetic or nutritional origin. The present study evaluated the plasma Hcy level, MTHFR C677T gene polymorphism, effect of folic acid (FA) supplementation ‚ and hemato-biochemical parameters in SCA and their effect on the vaso-occlusive crisis (VOC) in SCA patients of an Asian-Indian haplotype population. One hundred twenty cases of SCA (HbSS) and 50 controls with normal hemoglobin(HbAA) were studied. It was found that the plasma Hcy level ...
Source: Annals of Hematology - September 9, 2019 Category: Hematology Source Type: research

The Director of the NIH Lays Out His Vision of the Future of Medical Science
Our world has never witnessed a time of greater promise for improving human health. Many of today’s health advances have stemmed from a long arc of discovery that begins with strong, steady support for basic science. In large part because of fundamental research funded by the National Institutes of Health (NIH), which traces its roots to 1887, Americans are living longer, healthier lives. Life expectancy for a baby born in the U.S. has risen from 47 years in 1900 to more than 78 years today. Among the advances that have helped to make this possible are a 70% decline in the U.S. death rate from cardiovascular disease ...
Source: TIME: Science - October 24, 2019 Category: Science Authors: Dr. Francis S. Collins Tags: Uncategorized Healthcare medicine Source Type: news

The Genetic and Clinical Significance of Fetal Hemoglobin Expression in Sickle Cell Disease
Sickle cell disease (SCD) is phenotypically heterogenic. One major genetic modifying factor is the patient ’s level of fetal hemoglobin (HbF). The latter is determined by the patient’s β-globin gene cluster haplotype and cis-acting and trans-acting single gene polymorphisms (SNP) at other distant quantitative trait loci (QTL). The Arab/India haplotype is associated with persistently high HbF levels and also a relatively mild phenotype. This haplotype carries the Xmn1 (C/T) SNP, rs 7482144 in the HBG2 locus. The major identified trans-acting QTL contain SNPs residing in the BCL11A in chromosome 2 and the HMIP locus on ...
Source: Medical Principles and Practice - September 3, 2020 Category: Internal Medicine Source Type: research

Health ministry's fight against sickle cell anaemia to follow Gujarat playbook
Prevalent among the tribal population in India, sickle cell disease is a genetic condition that affects haemoglobin -- responsible for carrying oxygen in the body-- in red blood cells. Anaemia, debilitating acute and chronic pain, infection, acute chest syndrome, stroke, and renal failure are among the problems it can lead to.
Source: The Economic Times - February 1, 2023 Category: Consumer Health News Source Type: news

MTHFR C677T Polymorphism, Plasma Homocysteine, and PDGF-AA Levels and Transcranial Doppler Velocity in Children with Sickle Cell Disease
CONCLUSION: PDGF-AA and tHcy levels could be used as predictive markers for stroke in SCD children. MTHFR Polymorphism contributes to elevated tHcy levels.PMID:37260067
Source: Indian Pediatrics - June 1, 2023 Category: Pediatrics Authors: Asmaa A Mahmoud Nahla M S Abd El Hady Mohammed S Rizk Ahmed M El-Hawwary Nagwan Y Saleh Source Type: research