Association of plasma homocysteine level with vaso-occlusive crisis in sickle cell anemia patients of Odisha, India

AbstractVascular complications of sickle cell anemia (SCA) are influenced by many factors. Elevated plasma homocysteine (Hcy) is supposed to be an independent risk factor and is either genetic or nutritional origin. The present study evaluated the plasma Hcy level, MTHFR C677T gene polymorphism, effect of folic acid (FA) supplementation ‚ and hemato-biochemical parameters in SCA and their effect on the vaso-occlusive crisis (VOC) in SCA patients of an Asian-Indian haplotype population. One hundred twenty cases of SCA (HbSS) and 50 controls with normal hemoglobin(HbAA) were studied. It was found that the plasma Hcy level is signif icantly higher (p 
Source: Annals of Hematology - Category: Hematology Source Type: research

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ConclusionWe have constructed a stereotaxic template set of macaque brain named HJT, which standardizes macaque neuroimaging data analysis, supports novel radiotracer development and facilitates translational neuro-disorders research.
Source: NeuroImage - Category: Neuroscience Source Type: research
This study investigated the effects of pasture on nutritional characteristics and volatile components of sheep's milk, yoghurt and cheese produced in central Italy. During two grazing seasons (winter and spring) aliquots of fodder, yoghurt, fresh cheese and the corresponding ripened cheese were taken and analysed in relation to nutritional composition and volatile compounds. The grazing season influenced the chemical composition of the sheep's milk and dairy products, giving the cheese from the spring pasture a significantly higher dry matter content (61.26% vs 52.85%). Spring dairy products were also significantly higher ...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Publication date: Available online 12 October 2019Source: Veterinary MicrobiologyAuthor(s): E. Blázquez, C. Rodríguez, J. Ródenas, N. Navarro, R. Rosell, S. Pina-Pedrero, J.M. Campbell, M. Sibila, J. Segalés, J. Pujols, J. PoloAbstractLiquid porcine plasma is an animal origin raw material for the manufacturing process of spray-dried porcine plasma that is used in pig nutrition worldwide. In previous studies we found that the application of ultraviolet light C (UV-C) in liquid plasma that was inoculated with a variety of bacteria or viruses of importance in the swine industry can be considered as...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
This study aimed to evaluate the relation between serum adiponectin and changes in nutritional status of head trauma patients. Methods: The current prospective cohort study was carried out on head trauma patients who were hospitalized in ICU of a General Teaching Hospital, Sulaimani, Iraq. Patients were divided into two groups based on their serum adiponectin level during the first 24 hours of admission (
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Arch Acad Emerg Med Source Type: research
Authors: Bashir MU, Bhagra A, Kapa S, McLeod CJ Abstract Atrial fibrillation is the most common symptomatic arrhythmia that is associated with stroke. Contemporary management of the disease is focused on anticoagulation to prevent stroke, coupled with catheter ablation to limit symptoms and prevent deleterious cardiac remodeling. Emerging data highlights the importance of lifestyle modification by managing sleep apnea, increasing physical activity, and weight loss. There is significant data that supports a link between the autonomic nervous system, arrhythmia development, and atrial fibrillation therapy. It is like...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
Publication date: Available online 12 October 2019Source: Journal of Sound and VibrationAuthor(s): M. Dal Borgo, M. Ghandchi Tehrani, S.J. ElliottAbstractThis paper presents a theoretical and experimental study of a stroke limited inertial actuator when used for active vibration control. The active control system under investigation consists of the inertial actuator attached to a flexible structure, a collocated vibration sensor and a velocity feedback controller (VFC). Controlling low frequency motions or large amplitude vibrations requires a very long stroke for the proof mass. However, a physical limitation of inertial ...
Source: Journal of Sound and Vibration - Category: Physics Source Type: research
_______________ We are proud that Amazon India has selected The SharpBrains Guide to Brain Fitness: How to Optimize Brain Health and Performance at Any Age as part of its Kindle Weekly Deal running from October 13th to the 17th — when many bestselling eBooks will be discounted to just 49 rupees. – To benefit from the promotion, click HERE. – Readers in other countries can purchase the book at regular prices by clicking HERE. The book is also available in Spanish, Japanese, Polish and Portuguese. Book Description: “A much-needed resource to help us better understand our brains and mind...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Education & Lifelong Learning Health & Wellness Amazon India brain health brain training Brain-Fitness Kindle Weekly Deal neuroplasticity Source Type: blogs
Conclusion: The study shows that the use of 213Bi-PSMA/DOTATOC for the therapy of CRPC and NET, respectively, has been convenient, safe and straightforward. The external radiation doses to the occupational workers involved in different procedures were far below the dose limits prescribed by the Regulatory Authority (20mSv/yr). The dose rates from the treated patients showed no detrimental effect on public and environment. PMID: 31604889 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
In this study, the role of dihydrofolate reductase (DHFR), a target of MTX, in FA-mediated inhibition of MTX-induced EMT was evaluated. The inhibitory effects of FA and tetrahydrofolate (THF), a metabolite of FA produced by DHFR, on MTX-induced increases in mRNA expression of α-SMA, an EMT marker, were compared. The IC50 values of FA and THF for DHFR were 103.3 and 19.4 μM, respectively. In contrast, DHFR knockdown did not alter the mRNA expression of α-SMA. Notably, the inhibitory effect of FA, but not THF, on MTX-induced EMT was blunted in DHFR knockdown cells. These results suggested that DHFR may no...
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
The Box-tree Moth, Cydalima perspectalis, is an Asian species of moth (usually seen in (Japan, China, Taiwan, Korea, the Russian Far East, and India), that is gradually spreading, presumably with the advent of box hedges on new housing estates, across the South East of England. Box-tree Moth, Cydalima perspectalis (Walker, 1859), to actinic light Jul 2019, VC29 It would’ve arrived as eggs/larvae on imported box (Buxus), first recorded here in 2007. Its larvae can destroy a box hedge. Another reason to go native when it comes to planting…probably too late for native box now though. I saw my first one in the tra...
Source: David Bradley Sciencebase - Songs, Snaps, Science - Category: Science Authors: Tags: Sciencebase Source Type: blogs
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