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Condition: Obesity
Infectious Disease: Epidemics
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Total 151 results found since Jan 2013.
GSE72278 A novel lineage of adipose tissue regulatory T cells controls obesity and insulin resistance
Contributors : Emilie Stolarczyk ; Charlotte Bailey ; Natividad Garrido-Mesa ; Paul Lavender ; Richard Jenner ; Graham Lord ; Jane HowardSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe epidemic of obesity and its associated systemic metabolic complications continues to increase. Adipose tissue (AT)-associated T cells have been proposed to play an important role in the regulation of bodyweight and insulin sensitivity with a link to Th1 or Th2 lineage specification. A specific subset of regulatory T cells (TREGS) plays a critical and non-redundant role in controlling s...
Source: GEO: Gene Expression Omnibus - December 1, 2017 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Rate or Rhythm Control of Atrial Fibrillation - Pearls for the Internist.
Abstract
Atrial fibrillation is an epidemic in Asia that is increasingly prevalent. Apart from stroke risk stratification and management of anticoagulation, physicians managing this group of patients also need to determine an optimal strategy in terms of rate or rhythm control. With new techniques of catheter ablation to maintain patients in sinus rhythm, patients with atrial fibrillation now have more options for treatment, on top of pharmacological methods. This paper aims to review the current evidence for rate and rhythm control in both general patients and subgroups of interest commonly encountered in clinica...
Source: Annals of the Academy of Medicine, Singapore - November 1, 2017 Category: General Medicine Authors: Huang W, Keng FY, Ching CK Tags: Ann Acad Med Singapore Source Type: research
Atrial Fibrillation in Heart Failure: a Therapeutic Challenge of Our Times.
Authors: Batul SA, Gopinathannair R
Abstract
Atrial fibrillation (AF) and heart failure (HF) are growing cardiovascular disease epidemics worldwide. There has been an exponential increase in the prevalence of AF and HF correlating with an increased burden of cardiac risk factors and improved survival rates in patients with structural heart disease. AF is associated with adverse prognostic outcomes in HF and is most evident in mild-to-moderate left ventricular (LV) dysfunction where the loss of "atrial kick" translates into poorer quality of life and increased mortality. In the absence of underlying structural heart...
Source: Korean Circulation Journal - September 29, 2017 Category: Cardiology Tags: Korean Circ J Source Type: research
Obesity epidemic puts 240,000 lives at risk each year
BRITAIN ’S obesity epidemic has put hundreds of thousands at risk of heart disease and stroke, analysis shows.
Source: Daily Express - Health - September 24, 2017 Category: Consumer Health News Source Type: news
Melanocortin neurons: Multiple routes to regulation of metabolism
This article is part of a Special Issue entitled: Melanocortin Receptors - edited by Ya-Xiong Tao.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - September 19, 2017 Category: Molecular Biology Source Type: research
Associations between Greenness, Impervious Surface Area, and Nighttime Lights on Biomarkers of Vascular Aging in Chennai, India
Conclusion:
Greenness, ISA, and NTL were associated with increased SBP, DBP, and cPP, and with reduced FMD, suggesting a possible additional EVA pathway for the relationship between urbanization and increased CVD prevalence in urban India. https://doi.org/10.1289/EHP541
Received: 20 May 2016
Revised: 03 January 2017
Accepted: 23 January 2017
Published: 02 August 2017
Address correspondence to K.J. Lane, Yale School of Forestry and Environmental Studies, 195 Prospect Street, New Haven, CT 06511 USA. Telephone: (781) 696-4537; Email: kevin.lane@yale.edu
Supplemental Material is available online (https://doi.org/10.1289...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Hopkins Nursing—Dean on Chronic Disease / Pediatrics
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Source: Johns Hopkins University and Health Systems Archive - July 27, 2017 Category: Nursing Source Type: news
Adolescent weight gain confers long-term increased stroke risk: Weighty matters
Adult obesity has been consistently associated with risk of total, ischemic, and hemorrhagic stroke1–3; however, the degree to which change in weight and body mass index (BMI) during late childhood and adolescence affects adult risk of stroke has remained uncertain. Understanding this relationship is of particular importance given the rising obesity epidemic during childhood and adolescence.
Source: Neurology - July 24, 2017 Category: Neurology Authors: Rexrode, K. M., Kimm, S. Y. S. Tags: All Pediatric, Adolescence, Cohort studies, Infarction, Intracerebral hemorrhage EDITORIALS Source Type: research
Overweight teen boys have increased risk of stroke in later life
Conclusion
The findings of this large longitudinal cohort study seem to demonstrate a link between being overweight aged 20 and an increased risk of stroke.
This risk was regardless of whether the boy had been overweight aged 8 or not. There seemed to be no increased risk for boys who were overweight aged 8 but were a normal weight by the age of 20.
The study was conducted before the obesity epidemic, and might be even more relevant today.
But there are a number of considerations to take into account before we draw any conclusions:
Participants were followed up until they were 52-68, so all the strokes occurred at a r...
Source: NHS News Feed - June 29, 2017 Category: Consumer Health News Tags: Obesity Pregnancy/child Source Type: news
Overfed and Underfed: Global Food Extremes
The international community of nations has made commitments to eliminate hunger, achieve food security and improved nutrition by 2030 and also to promote and protect health through nutritious diet, healthy eating and increased physical activity. Credit: IPSBy Joseph ChamieNEW YORK, Jun 12 2017 (IPS)Global food extremes of chronic undernourishment and obesity have brought about a bipolar world of hundreds of millions of underfed and overfed people. Of the world’s population of 7.5 billion the proportions suffering from chronic undernourishment and those afflicted by obesity are similar, approximately 11 percent or togethe...
Source: IPS Inter Press Service - Health - June 12, 2017 Category: International Medicine & Public Health Authors: Joseph Chamie Tags: Development & Aid Food & Agriculture Global Headlines Health Poverty & SDGs Regional Categories Source Type: news
Melanocortin neurons: multiple routes to regulation of metabolism.
Abstract
The burden of disability, premature death, escalating health care costs and lost economic productivity due to obesity and its associated complications including hypertension, stroke, cardiovascular disease and type 2 diabetes is staggering [1, 2]. A better understanding of metabolic homeostatic pathways will provide us with insights into the biological mechanisms of obesity and how to fundamentally address this epidemic [3-6]. In mammals, energy balance is maintained via a homeostatic system involving both peripheral and central melanocortin systems; changes in body weight reflect an unbalance of the ener...
Source: Biochimica et Biophysica Acta - May 9, 2017 Category: Biochemistry Authors: Shen WJ, Yao T, Kong X, Williams KW, Liu T Tags: Biochim Biophys Acta Source Type: research
Achieving better detection of vascular risk factors for stroke prevention (P4.062)
Conclusions:The concept of vital station is a useful means of detecting vascular risk factor before appearance of noticeable symptoms and thus offers the benefit of being able to treat the disease much earlier which can lead to reduction of disease burden & economic losses and thus offers better health outcome.Disclosure: Dr. Mehndiratta has nothing to disclose. Dr. Wadhai has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mehndiratta, M. M., Wadhai, S. Tags: General Neurology: Vascular Neurology Source Type: research
New Evidence Linking Obesity and Food Addiction
Obesity rates have skyrocketed over the past few decades. In the United States, approximately 35% of adults are now considered obese, with more than 60% categorized as overweight (1). The health consequences of obesity are substantial. Obesity increases the risk of developing several debilitating conditions, such as diabetes, heart disease, stroke, and mental illness. Because the global obesity epidemic is generally believed to be caused by excessive caloric intake, there has been increasing interest in understanding the neurobiological mechanisms contributing to overeating, defined as continued eating in the absence of me...
Source: Biological Psychiatry - April 11, 2017 Category: Psychiatry Authors: Elise C. Cope, Elizabeth Gould Tags: Commentary Source Type: research
Migraine and the Risk of Carotid Artery Dissection
Stroke incidence is increasing among patients aged 40 to 60 years —faster than in older age cohorts. Preliminary evidence suggests that ischemic stroke—not hemorrhage or subarachnoid hemorrhage—accounts for the increase. Many speculate that increasing incidences of classic vascular risk factors among young patients contribute to the increased incidence of st roke. Certainly, we are all aware of the obesity epidemic and continued prevalence of smoking, leading to premature atherosclerosis. Furthermore, equally relevant causes of stroke in the young include migraine, drug abuse, cervical arterial dissections, patent fo...
Source: JAMA Neurology - March 6, 2017 Category: Neurology Source Type: research
Contribution of Maladaptive Adipose Tissue Expansion to Development of Cardiovascular Disease.
Authors: Jia G, Jia Y, Sowers JR
Abstract
The overweight and obesity epidemic has led to an increase in the metabolic syndrome and associated cardiovascular disease (CVD). These abnormalities include insulin resistance, type 2 diabetes mellitus, vascular stiffness, hypertension, stroke, and coronary heart disease. Visceral white adipocyte tissue (WAT) expansion and associated fibrosis/stiffness of WAT promote insulin resistance and CVD through increases in proinflammatory adipokines, oxidative stress, activation of renin-angiotensin-aldosterone system, dysregulation of adipocyte apoptosis and autophagy, dysfunction...
Source: Comprehensive Physiology - February 1, 2017 Category: Physiology Tags: Compr Physiol Source Type: research
