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Condition: Obesity
Drug: Tamoxifen
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Total 34 results found since Jan 2013.
Sex differences in the effects of brown adipocyte CD47 deficiency on age-related weight change and glucose homeostasis
Biochem Biophys Res Commun. 2023 Jul 22;676:78-83. doi: 10.1016/j.bbrc.2023.07.042. Online ahead of print.ABSTRACTOur previous studies demonstrated that mice with global CD47 deficiency are lean and resistant to diet or aging-associated obesity and metabolic complications. This protective effect is partially through modulating brown fat function. To definitively determine the role of brown fat CD47 in age-related metabolic homeostasis, inducible brown adipocyte-specific cd47 deficient mice were generated by crossbreeding cd47 floxed mice with UCP1-CreERT2 mice and characterized in this study. Efficient knockdown of CD47 in...
Source: Biochemical and Biophysical Research communications - July 27, 2023 Category: Biochemistry Authors: Dong Li Taesik Gwag Shuxia Wang Source Type: research
Venous thromboembolism and breast cancer
Bull Cancer. 2023 Jul 18:S0007-4551(23)00296-5. doi: 10.1016/j.bulcan.2023.06.001. Online ahead of print.ABSTRACTBreast cancer is the most common cancer in women. Patients with breast cancer have a 4-fold increased risk of venous thromboembolism (VTE) compared to age- and sex-matched controls without cancer. VTE remains the second leading cause of death in cancer patients and an independent risk factor for mortality. In women with breast cancer, the main risk factors for developing VTE are increasing age, obesity, disease stage, central catheter placement and cancer treatments, including surgery, chemotherapy, hormonothera...
Source: Bulletin du Cancer - July 20, 2023 Category: Cancer & Oncology Authors: Benjamin Crichi Emilie Moati Carlotta Cacciatore Dominique Farge Corinne Frere Source Type: research
Adherence to oral endocrine therapy in racial/ethnic minority patients with low socioeconomic status before and during the COVID-19 pandemic
CONCLUSION: OET adherence was significantly reduced during the COVID-19 pandemic in racial/ethnic minority patients with low SES. Patient-centered interventions are necessary to improve OET adherence in these patients.PMID:37380914 | DOI:10.1007/s11096-023-01609-6
Source: Clinical Genitourinary Cancer - June 28, 2023 Category: Cancer & Oncology Authors: Sama Rahimi Onyebuchi Ononogbu Anjana Mohan Daniel Moussa Susan Abughosh Meghana V Trivedi Source Type: research
Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy
CONCLUSIONS: DRP1 is an essential factor in mitochondrial quality control during obesity cardiomyopathy that controls multiple forms of mitophagy. Although DRP1 regulates conventional mitophagy through a mitochondria-associated membrane-independent mechanism during the acute phase, it acts as a component of the mitophagy machinery at the mitochondria-associated membranes in alternative mitophagy during the chronic phase of HFD consumption.PMID:37232152 | DOI:10.1161/CIRCRESAHA.123.322512
Source: Circulation Research - May 26, 2023 Category: Cardiology Authors: Mingming Tong Risa Mukai Satvik Mareedu Peiyong Zhai Shin-Ichi Oka Chun-Yang Huang Chiao-Po Hsu Fawad A K Yousufzai Luke Fritzky Wataru Mizushima Gopal J Babu Junichi Sadoshima Source Type: research
Tamoxifen induced hepatic steatosis in high-fat feeding rats through SIRT1-Foxo1 suppression and LXR-SREBP1c activation
CONCLUSIONS: These results indicated that TAM-induced hepatic steatosis was based on SIRT1-p-FoxO/LXRα-sterol regulatory element binding protein 1c pathway under HFD condition. SIRT1 agonist might be a potential therapeutic drug to relieve this side effect.HIGHLIGHTS: Tamoxifen increased lipid synthesis and regulated lipid transport in HFD rat liver.p-FoxO1/LXRα-SREBP1c signaling was upregulated through the inhibition of SIRT1 in tamoxifen-induced hepatic steatosis under HFD condition.SIRT1 agonist SRT1720 could relieve tamoxifen-induced hepatic steatosis.PMID:36051666 | PMC:PMC9424708 | DOI:10.1093/toxres/tfac043
Source: Cell Research - September 2, 2022 Category: Cytology Authors: Miao Li Yu Cai Xi Chen Luyong Zhang Zhenzhou Jiang Qinwei Yu Source Type: research
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine
CONCLUSION: Collectively, loss of O-GlcNAcylation in the intestine reduced glucose absorption via suppression of SGLT1 expression, which may lead to new treatments for malabsorption, obesity and diabetes.PMID:35189429 | DOI:10.1016/j.molmet.2022.101458
Source: Molecular Medicine - February 21, 2022 Category: Molecular Biology Authors: Kimihiro Nishimura Yukihiro Fujita Shogo Ida Tsuyoshi Yanagimachi Natsuko Ohashi Kiyoto Nishi Atsushi Nishida Yasumasa Iwasaki Katsutaro Morino Satoshi Ugi Eiichiro Nishi Akira Andoh Hiroshi Maegawa Source Type: research
Breast cancer endocrine therapy promotes weight gain with distinct adipose tissue effects in lean and obese female mice
Endocrinology. 2021 Aug 19:bqab174. doi: 10.1210/endocr/bqab174. Online ahead of print.ABSTRACTBreast cancer survivors treated with tamoxifen and aromatase inhibitors report weight gain and have an elevated risk of type 2 diabetes, especially if they have obesity. Pre-clinical reports are disconnected from patient experiences, but many used high doses of tamoxifen. We investigated the impact of breast cancer endocrine therapies in a pre-clinical model of obesity and in a small group of breast adipose tissue samples from women taking tamoxifen to understand the clinical findings. Mature female mice were housed at thermoneut...
Source: Endocrinology - August 19, 2021 Category: Endocrinology Authors: Rebecca L Scalzo Rebecca M Foright Sara E Hull Leslie A Knaub Stevi Johnson-Murguia Fotobari Kinanee Jeffrey Kaplan Julie A Houck Ginger Johnson Rachel R Sharp Austin E Gillen Kenneth L Jones Anni M Y Zhang James D Johnson Paul S MacLean Jane E B Reusch S Source Type: research
