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High-mobility group box 2 protein is essential for the early phase of adipogenesis
Biochem Biophys Res Commun. 2021 Apr 13;557:97-103. doi: 10.1016/j.bbrc.2021.03.149. Online ahead of print.ABSTRACTUnderstanding of the mechanism of adipogenesis is essential for the control of obesity, which predisposes toward numerous health problems. High-mobility group box protein 2 (HMGB2) is a non-histone chromosomal protein that facilitates DNA replication, transcription, recombination, and repair. Here, we studied the role of HMGB2 in adipogenic differentiation. The expression of HMGB2 was measured at the mRNA and protein levels in cultured 3T3-L1 pre-adipocyte cells and during the process of adipogenic differentia...
Source: Biochemical and Biophysical Research communications - April 16, 2021 Category: Biochemistry Authors: Hidetaka Morinaga Yoshimi Muta Tomoko Tanaka Makito Tanabe Yuriko Hamaguchi Toshihiko Yanase Source Type: research

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1R Onto the Primary Cilium Associated with Cilia Elongation
This study tested the hypothesis that changes in primary cilia structure are required for stem cell differentiation. hMSCs expressed primary cilia which were labelled with acetylated alpha tubulin and visualized by confocal microscopy. Chemically induced differentiation resulted in lineage specific changes in cilia length and prevalence independent of cell cycle. In particular adipogenic differentiation resulted in cilia elongation associated with the presence of dexamethasone, whilst insulin had an inhibitory effect on cilia length. Over a seven day time course adipogenic differentiation media resulted in cilia elongation...
Source: Stem Cells - February 18, 2015 Category: Stem Cells Authors: Melis T. Dalbay, Stephen D. Thorpe, John T. Connelly, J. Paul Chapple, Martin M. Knight Tags: Tissue‐specific stem cells Source Type: research

Leptin Enhances ICAM-1 Expression, Induces Migration and Cytokine Synthesis, and Prolongs Survival of Human Airway Epithelial Cells.
Abstract There is rising interest in how obesity affects respiratory diseases, since epidemiological findings indicate a strong relationship between the two conditions. Leptin is a potent adipokine produced mainly by adipocytes. It regulates energy storage and expenditure and also induces inflammation. Previous studies have shown that leptin is able to activate inflammatory cells such as lymphocytes and granulocytes, but little is known about its effect on lung structural cells. The present study investigated the effects of leptin on human airway epithelial cells by using human primary airway epithelial cells and ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - August 14, 2015 Category: Cytology Authors: Suzukawa M, Koketsu R, Baba S, Igarashi S, Nagase H, Yamaguchi M, Matsutani N, Kawamura M, Shoji S, Hebisawa A, Ohta K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - June 20, 2016 Category: Biochemistry Authors: Gaurav Pandey, Kripa Shankar, Ekta Makhija, Anil Gaikwad, Carolyn Ecelbarger, Anil Mandhani, Aneesh Srivastava, Swasti Tiwari Tags: Article Source Type: research

Heme oxygenase-1 mediates anti-adipogenesis effect of raspberry ketone in 3T3-L1 cells
Conclusion : RK may exert anti-adipogenic effects through modulation of the HO-1/Wnt/beta-catenin signaling pathway. Graphical abstract
Source: Phytomedicine - May 22, 2017 Category: Drugs & Pharmacology Source Type: research

miRNA-218 Targets Lipin-1 and Glucose Transporter Type 4 Genes in 3T3-L1 Cells Treated With Lopinavir/Ritonavir
Conclusion: 3T3-L1 cells, treated with LPV/RTV, show altered lipid content due to increased miRNA-218 levels, which affects lipin-1 mRNA. Moreover, increased miRNA-218 levels were inversely correlated with changes in GLUT-4 expression, which suggests a role for miRNA-218 in mediating the insulin resistance consequent to cART. Introduction Metabolic syndrome is a serious consequence of combined Antiretroviral Therapy (cART). HIV-associated metabolic syndrome is often accompanied by lipodystrophy (LS), the redistribution of body fat with loss of subcutaneous adipose tissue in face, limbs and buttocks, concomitant wit...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

iTRAQ-and LC-MS/MS-based quantitative proteomics reveals Pqlc2 as a potential regulator ofhepatic glucose metabolism and insulin signaling pathway during fasting.
In conclusion, our study provides important information onprotein profile change during prolonged fasting with iTRAQ-and LC-MS/MS-based quantitative proteomics, and identifies Pqlc2 as a potential regulator of hepatic glucose metabolism and insulin signaling pathwayin this process. PMID: 33051888 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - October 13, 2020 Category: Drugs & Pharmacology Authors: Sun DY, Fu JT, Li GQ, Zhang WJ, Zeng FY, Tong J, Miao CY, Li DJ, Wang P Tags: Clin Exp Pharmacol Physiol Source Type: research

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling
Conclusions/interpretationIn summary, our study identifies HAND2 as a novel obesity-linked adipocyte transcription factor, highlighting new mechanisms of GR-dependent adipogenesis in humans and mice.Data availabilityArray data have been submitted to the GEO database at NCBI (GSE148699).Graphical abstract
Source: Diabetologia - June 30, 2021 Category: Endocrinology Source Type: research