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The Role of the Low-Density Lipoprotein/High-Density Lipoprotein Cholesterol Ratio as an Atherogenic Risk Factor in Young Adults with Ischemic Stroke: A Case-Control Study
This study investigated the TC/HDL-C ratio and the LDL-C/HDL-C ratio, which may be more specific and common lipid parameters in young patients with ischemic stroke. This study aimed to demonstrate the sensitivity and specificity of TC/HDL-C and LDL-C/HDL-C ratios as atherogenic markers for young adult ischemic strokes. This trial was conducted as a retrospective case-control study. A total of 123 patients (patient group) and 86 healthy individuals (control group) aged 18-50 years were randomly selected from four different hospitals. Lipid parameters and TC/HDL-C and LDL-C/HDL-C ratios were compared between these two groups...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Sibel Ciplak Ahmet Adiguzel Yusuf Ziya Deniz Melike Aba Unal Ozturk Source Type: research

Predicting Statin Adherence Following Hospital Discharge for Acute Coronary Syndromes: What ’s the Score?
The use of statins following acute coronary syndromes (ACS) is well documented to improve mortality and reduce hospitalisation, revascularisation and risk of stroke [1], and has become a frequently used benchmark to audit in-hospital care of such patients. Much less is known about adherence to statins following discharge —and the factors influencing this—which is the subject of the paper by Liao et al. in this edition of Heart, Lung and Circulation [2].
Source: Heart, Lung and Circulation - May 1, 2023 Category: Cardiology Authors: Thomas R. Barlow, Sameer Karve, David Brieger, Harry C. Lowe Tags: Editorial Source Type: research

Mitral Valve Blood Cyst and Multi-Territory Ischaemic Stroke
A 78-year-old male with a history of hypertension and hypercholesterolaemia was admitted to hospital with acute left eye visual loss and diagnosed with retinal artery occlusion. Magnetic resonance imaging (MRI) revealed multiple, bilateral cerebral infarcts involving supra- and infra-tentorial brain consistent with acute ischaemic stroke from a central embolic source. Extended ambulatory electrocardiographic monitoring displayed sinus rhythm with no evidence of atrial flutter or fibrillation. Transthoracic echocardiography (TTE) revealed a cystic structure associated with the mitral valve, with no restriction or regurgitation.
Source: Heart, Lung and Circulation - February 16, 2023 Category: Cardiology Authors: Caitlin Paul, Luke Cieslik, Alan Appelbe, Catherine Jaworski Tags: Image Source Type: research

PCSK9 inhibition in patients with acute stroke and symptomatic intracranial atherosclerosis: protocol for a prospective, randomised, open-label, blinded end-point trial with vessel-wall MR imaging
BMJ Open. 2022 Apr 29;12(4):e060068. doi: 10.1136/bmjopen-2021-060068.ABSTRACTINTRODUCTION: Dual antiplatelet therapy and high-intensity statins are the mainstay treatment in patients with acute stage, symptomatic intracranial atherosclerotic stenosis (ICAS). Alirocumab is a monoclonal antibody that can inhibit proprotein convertase subtilisin-kexin type 9 and effectively lower low-density lipoprotein cholesterol levels with less side effects than statins. We hypothesise that alirocumab treatment in addition to statin therapy could stabilise intracranial plaque and reduce arterial stenosis.METHODS AND ANALYSIS: In this pro...
Source: Atherosclerosis - April 29, 2022 Category: Cardiology Authors: Yen-Chu Huang Chia-Hao Chang Yuan-Hsiung Tsai Hsu-Huei Weng Leng-Chieh Lin Jiann-Der Lee Source Type: research

Comparing pharmacotherapy in MINOCA versus medically managed obstructive acute coronary syndrome
This study uniquely compares the management and outcomes of MINOCA patients with a medically managed obstructive ACS (M-ACS) population. We retrospectively analysed registry data for consecutive patients admitted to the Gold Coast University Hospital with ACS requiring coronary angiography and identified patients with MINOCA and M-ACS. Baseline characteristics, pharmacological therapy and in-hospital outcomes were compared. In hospital outcomes were composite NACE, heart failure, stroke and major bleeding. Multivariate regression analysis was also performed to identify independent predictors of MINOCA. Multivariate regress...
Source: Heart and Vessels - March 23, 2022 Category: Cardiology Source Type: research

Prognostic indicators for the onset of ischaemic versus haemorrhagic stroke in stable coronary artery disease
Medicine (Baltimore). 2021 Dec 3;100(48):e27973. doi: 10.1097/MD.0000000000027973.ABSTRACTThe incidence of stroke may be increased in patients with coronary artery disease (CAD). We aimed to investigate the specific risk factors for the development of ischaemic and haemorrhagic stroke in stable CAD patients.Patients with stable CAD were prospectively enrolled for future cardiovascular events in Taiwan. All the patients had received coronary interventions and were stable for least 1 month before enrolment. The incidence of ischaemic stroke was identified and confirmed by telephone and hospital records. Baseline characterist...
Source: Atherosclerosis - January 20, 2022 Category: Cardiology Authors: Wei-Ting Wang Tao-Cheng Wu Wei-Kung Tseng Yen-Wen Wu Tsung-Hsien Lin Hung-I Yeh Kuan-Cheng Chang Ji-Hung Wang Hsin-Bang Leu Wei-Hsian Yin Chau-Chung Wu Jaw-Wen Chen Source Type: research

Comparing pharmacotherapy in MINOCA versus medically managed obstructive acute coronary syndrome
This study uniquely compares the management and outcomes of MINOCA patients with a medically managed obstructive ACS (M-ACS) population. We retrospectively analysed registry data for consecutive patients admitted to the Gold Coast University Hospital with ACS requiring coronary angiography and identified patients with MINOCA and M-ACS. Baseline characteristics, pharmacological therapy and in-hospital outcomes were compared. In hospital outcomes were composite NACE, heart failure, stroke and major bleeding. Multivariate regression analysis was also performed to identify independent predictors of MINOCA. Multivariate regress...
Source: Heart and Vessels - October 10, 2021 Category: Cardiology Source Type: research

Cancer-Associated Atherothrombosis: The Challenge
Int J Angiol DOI: 10.1055/s-0041-1729920The association between venous thrombosis and malignancy, having typical features of a paraneoplastic syndrome, has been established for a century. Currently, it is recognized that arterial thromboembolism (ATE) may also behave as a paraneoplastic syndrome. Recent matched cohort studies, systematic reviews, and observational studies concur in showing an increased incidence of acute coronary events, ischemic stroke, accelerated peripheral arterial disease, and in-stent thrombosis during the 6-month period before cancer diagnosis, peaking for 30 days immediately before cancer diagnosis...
Source: International Journal of Angiology - July 19, 2021 Category: Cardiology Authors: Naschitz, Jochanan E. Tags: Review Article Source Type: research

Impact of high-dose statin on cardiovascular outcomes in real-world patients with ST-elevation acute myocardial infarction
AbstractLittle is known about the impact of a high-dose statin on cardiovascular outcomes after ST-elevation acute myocardial infarction (STEMI) in real-world Japanese patients. Between July 2011 and June 2017, 1110 consecutive STEMI patients underwent primary percutaneous coronary intervention at our hospital and were discharged. A high-dose statin was administered in 117 patients (10.5%) and non-high-dose statin was administered in 947 patients (85.3%). The low-density lipoprotein cholesterol level was significantly higher in the high-dose statin group at admission (129.8  ± 44.9 vs. 110.4 ± 32.7,p <  0....
Source: Heart and Vessels - September 2, 2020 Category: Cardiology Source Type: research

Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting
This study assessed the safety and usefulness of pretreatment using a high-dose strong statin (HDSS) to reduce the periprocedural ischemic complications of CAS. We analyzed 117 carotid lesions treated by CAS that were evaluated with magnetic resonance imaging (MRI) within 48  h after the procedure. For 67 lesions, an HDSS (rosuvastatin 20 mg or atorvastatin 40 mg daily) were prescribed from at least 14 days before CAS to at least 14 days after procedure (HDSS group). Clinical and angiographic data, as well as in-hospital outcomes, of the HDSS group were retrospecti vely compared with 50 lesions with conventional treat...
Source: Heart and Vessels - January 9, 2020 Category: Cardiology Source Type: research

Phospholipase A 2 is an inflammatory predictor in Cardiovascular Diseases: Is there any spacious room to prove the causation?
Authors: Santoso A, Heriansyah T, Rochman S Abstract Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) is an enzyme family of phospholipase A 2 produced by the inflammatory cell in atherosclerotic plaque. It is transported in the circulation, attached mainly to low-density lipoprotein-cholesterol (LDL-C). It hydrolyzes glycerophospholipids particularly fatty acids at the sn-2 position and produces numerous bioactive lipids; and leads to endothelial dysfunction, atherosclerotic plaque inflammation, and development of the necrotic core in plaques. There are two kinds of phospholipase A 2 , namely: secretory phosph...
Source: Current Cardiology Reviews - June 1, 2019 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research

Abstract P201: Prevalence of Metabolic Syndrome in Hypertensive Patients Session Title: Onsite Poster Competition I With Reception
This study was done to find out the prevalence of metabolic syndrome among newly diagnosed hypertensive patients in a tertiary care hospital of northern India, Guru Nanak Dev hospital, attached to Government Medical College, Amritsar, India.Methods: It is a hospital based cross sectional study involving one hundred newly diagnosed subjects with hypertension above the age 20 years. High blood pressure was defined according to Joint National committe-7 (JNC-7) guidelines, taking systolic BP> 140 and diastolic BP>90 as hypertension. Exclusion criteria included secondary hypertension, secondary cause of obesity, pregnancy, acu...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nirankar Singh Neki, Jaswinder Singh Tags: Poster Abstract Presentations Source Type: research

Racial-Ethnic Disparities in Acute Stroke Care in the Florida-Puerto Rico Collaboration to Reduce Stroke Disparities Study Epidemiology
We examined race‐ethnic disparities in acute stroke performance metrics in a voluntary stroke registry among Florida and Puerto Rico Get With the Guidelines‐Stroke hospitals.Methods and ResultsSeventy‐five sites in the Florida Puerto Rico Stroke Registry (66 Florida and 9 Puerto Rico) recorded 58 864 ischemic stroke cases (2010–2014). Logistic regression models examined racial‐ethnic differences in acute stroke performance measures and defect‐free care (intravenous tissue plasminogen activator treatment, in‐hospital antithrombotic therapy, deep vein thrombosis prophylaxis, discharge antithrombotic therapy, a...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Sacco, R. L., Gardener, H., Wang, K., Dong, C., Ciliberti-Vargas, M. A., Gutierrez, C. M., Asdaghi, N., Burgin, W. S., Carrasquillo, O., Garcia-Rivera, E. J., Nobo, U., Oluwole, S., Rose, D. Z., Waters, M. F., Zevallos, J. C., Robichaux, M., Waddy, S. P., Tags: Epidemiology, Race and Ethnicity, Treatment, Cerebrovascular Disease/Stroke Original Research Source Type: research

Impact of Insurance Status on Outcomes and Use of Rehabilitation Services in Acute Ischemic Stroke: Findings From Get With The Guidelines-Stroke Health Services and Outcomes Research
The objective was to determine whether patients without insurance or with government‐sponsored insurance had worse quality of care or in‐hospital outcomes in acute ischemic stroke.Methods and ResultsMultivariable logistic regressions with generalized estimating equations stratified by age under or at least 65 years were adjusted for patient demographics and comorbidities, presenting factors, and hospital characteristics to determine differences in in‐hospital mortality and postdischarge destination. We included 589 320 ischemic stroke patients treated at 1604 US hospitals participating in the Get With The Guideline...
Source: JAHA:Journal of the American Heart Association - November 13, 2016 Category: Cardiology Authors: Medford-Davis, L. N., Fonarow, G. C., Bhatt, D. L., Xu, H., Smith, E. E., Suter, R., Peterson, E. D., Xian, Y., Matsouaka, R. A., Schwamm, L. H. Tags: Ischemic Stroke Original Research Source Type: research

Impact of Increased Early Statin Administration on Ischemic Stroke Outcomes: A Multicenter Electronic Medical Record Intervention Stroke
We examined the relationship between intervention and outcome using autoregressive integrated moving average (ARIMA) time‐series modeling. The EMR intervention increased both overall in‐hospital statin administration (from 87.2% to 90.7%, P
Source: JAHA:Journal of the American Heart Association - July 28, 2016 Category: Cardiology Authors: Flint, A. C., Conell, C., Klingman, J. G., Rao, V. A., Chan, S. L., Kamel, H., Cullen, S. P., Faigeles, B. S., Sidney, S., Johnston, S. C. Tags: Ischemic Stroke, Neuroprotectants Original Research Source Type: research

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