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Total 26 results found since Jan 2013.

Scientists develop blueprint for turning stem cells into sensory interneurons
Key takeaways:Just like the real thing.The stem cell –derived interneurons, which play a role in sensations like touch and pain, are indistinguishable from their real-life counterparts in the body.Tomorrow ’s therapies. In addition to potential treatments for injury-related sensation loss, the discovery could lead to new methods for screening drugs for chronic pain.Moving forward. While stem cells from mice were used in the research, scientists are now working to replicate the findings with human cells.Researchers at the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have develop...
Source: UCLA Newsroom: Health Sciences - July 19, 2022 Category: Universities & Medical Training Source Type: news

Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB/c Mice through the Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Pathway
In this study, we evaluated the effects of pinocembrin on human HaCaT keratinocytes and BALB/c mice with imiquimod- (IMQ-) induced psoriatic dermatitis. In interferon-γ- (IFN-γ-) activated HaCaT cells, pinocembrin reduced the expression of inflammatory cytokines, namely, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and keratinocyte proliferation markers, namely, keratin (K)16, K17, and Ki-67. The mechanism underlying these inhibitory effects involved the regulation of the heme oxygenase- (HO-) 1/signal transducer and activator of transcription (STAT) 3 pathway. In the IMQ-induced psoriatic dermatitis mouse mo...
Source: Evidence-based Complementary and Alternative Medicine - February 4, 2022 Category: Complementary Medicine Authors: Kuo-Kuei Huang Meng-Nan Lin Hui-Chun Hsu Yi-Ling Hsu Ting-Ni Huang I-Huang Lu I-Hong Pan Source Type: research

Chronic itch induced by thalamic deep brain stimulation: a case for a central itch centre
Central itch syndrome has been previously described in conditions such as stroke. The neurophysiology of central itch syndrome has been investigated in non-human primates but remains incompletely understood.
Source: Journal of Translational Medicine - October 16, 2021 Category: Research Authors: Luciano Furlanetti, Harutomo Hasegawa, Natasha Hulse, Rachael Morris-Jones and Keyoumars Ashkan Tags: Research Source Type: research

High cholesterol: The sign on your face that can be 'itchy or tender to touch' - doctor
HIGH cholesterol can pave the way to life-threatening complications, such as a heart attack or stroke, so reducing your levels is critical. According to Consultant Cardiologist Doctor Brian Clapp, an "itchy or tender to touch" warning sign may show up on your face.
Source: Daily Express - Health - August 21, 2021 Category: Consumer Health News Source Type: news

Inflammation-Related circRNA Polymorphism and Ischemic Stroke Prognosis
AbstractCircRNAs belong to a novel class of noncoding RNAs that are generated by exons of genes by alternative mRNA splicing and involved in pathophysiological processes of ischemic stroke by regulating neuro-inflammation. A total of 982 patients were enrolled in our study for stroke recovery analysis. The aim of our study was to first explore the association between the inflammation-related circRNA polymorphism and functional outcome 3  months after ischemic stroke by using multivariate logistic regression model. Next, we further investigated the role of circRNA polymorphism in predicting stroke recurrence by using Cox p...
Source: Journal of Molecular Neuroscience - July 17, 2021 Category: Neuroscience Source Type: research

Itch in Skin of Color: A multicenter cross-sectional study
Br J Dermatol. 2021 Apr 24. doi: 10.1111/bjd.20403. Online ahead of print.ABSTRACTChronic pruritus is associated with a significant reduction in quality of life. Patients with chronic pruritus endorse similar levels of quality of life impairment as patients with stroke1 , and present with greater rates of psychiatric illnesses, such as depression and anxiety2,3 . The prevalence and clinical presentation of chronic pruritus have been suggested to vary between racial and ethnic groups.4.PMID:33893648 | DOI:10.1111/bjd.20403
Source: The British Journal of Dermatology - April 24, 2021 Category: Dermatology Authors: N Sutaria V Parthasarathy Y S Roh J Choi Z A Bordeaux P Trinh T K Le Y R Semenov S G Kwatra Source Type: research

Clinical presentation, management, and pathophysiology of neuropathic itch
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Martin Steinhoff, Martin Schmelz, Imre Lőrinc Szabó, Anne Louise OaklanderSummaryUnlike conventional itch, neuropathic itch develops in normal skin from excess peripheral firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom of the same central and peripheral nervous system disorders that cause neuropathic pain, such as sensory polyneuropathy, radiculopathy, herpes zoster, stroke, or multiple sclerosis, and lesion location affects symptoms more than aetiology. The causes of neuropathic itch are h...
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research

7 Foot Problems That Can Be Serious
If you want to know the state of your health, try looking down. “There’s no question it’s extremely important that people pay attention to their feet,” says Terry Philbin, D.O., spokesperson for the American Academy of Orthopedic Surgeons (AAOS) and a foot and ankle specialist at the Orthopedic Foot and Ankle Center in Westerville, Ohio. The condition of your feet can give you clues to a host of medical issues, such as diabetes, arthritis, and even heart disease. Read on to find out what to look for and what it may mean. 1. Pain “There’s no pain that should be ignored,” says Jane ...
Source: Healthy Living - The Huffington Post - November 12, 2016 Category: Consumer Health News Source Type: news

Neurologic Itch Management.
Authors: Şavk E Abstract Neurologic itch is defined as pruritus resulting from any dysfunction of the nervous system. Itch arising due to a neuroanatomic pathology is seen to be neuropathic. Causes of neuropathic itch range from localized entrapment of a peripheral nerve to generalized degeneration of small nerve fibers. Antipruritic medications commonly used for other types of itch such as antihistamines and corticosteroids lack efficacy in neuropathic itch. Currently there are no therapeutic options that offer relief in all types of neuropathic pruritus, and treatment strategies vary according to etiology. It is...
Source: Current Problems in Dermatology - September 1, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research

How To Find Your Calling (From 5 People Who Found Theirs)
Why does our culture perpetuate the belief that “finding oneself” is an age-specific phase, reserved only for angst-ridden teenagers and wanderlust-stricken 20-somethings? The notion of finding a passion is all-too-frequently aligned with youth and impulsivity, but truthfully, we’re all quietly seeking our next challenge, our next calling. We’re of the belief that it’s never too late to course correct your life, and given the job-hopping numbers, we’re probably not the only ones. Though the U.S. Bureau of Labor Statistics does not regularly track career changes, in a recent study of late...
Source: Healthy Living - The Huffington Post - August 18, 2016 Category: Consumer Health News Source Type: news

Don’t shrug off shingles
If you had chickenpox as a kid, there is a good chance you may develop shingles later in life. “In fact, one in three is predicted to get shingles during their lifetime,” says Dr. Anne Louise Oaklander, director of the Nerve Unit at Harvard-affiliated Massachusetts General Hospital. The same varicella-zoster virus that causes chickenpox also causes shingles. After the telltale spots of chickenpox vanish, the virus lies dormant in your nerve cells near the spinal cord and brain. When your immunity weakens from normal aging or from illnesses or medications, the virus can re-emerge. It then travels along a nerve to trigge...
Source: New Harvard Health Information - February 18, 2016 Category: Consumer Health News Authors: Matthew Solan Tags: Healthy Aging Infectious diseases Vaccines Source Type: news