Filtered By:
Condition: Hyperactivity

This page shows you your search results in order of date.

Order by Relevance | Date

Total 16 results found since Jan 2013.

Increasing the bioactivity of kynurenine by ultraviolet irradiation via resonance energy transfer in vitro
Anal Biochem. 2022 Feb 15:114605. doi: 10.1016/j.ab.2022.114605. Online ahead of print.ABSTRACTKynurenine (Kyn) is involved in a variety of physiological/pathological reactions via activating aryl hydrocarbon receptor (Ahr). However, how to activate Ahr by Kyn under physiological/pathological conditions is still unclear. Here, we presented that Kyn (8 μM, a concentration less than the dose of Kyn-induced Ahr activation) significantly induced the nuclear transfer of Ahr and the expression of cytochrome P450 1A1 (CYP1A1, a classic biomarker for Ahr activation) when co-administered with ultraviolet (UV) irradiation in 95D ce...
Source: Analytical Biochemistry - February 19, 2022 Category: Biochemistry Authors: Yunqing Duan Junfang Liu Fuxiang Wang Zhiqing Duan Source Type: research

Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat.
Abstract Malignant ventricular arrhythmias (VAs) following myocardial infarction (MI) is a lethal complication resulting from sympathetic nerve hyperactivity. Numerous evidence have shown that inflammation within the paraventricular nucleus (PVN) participates in sympathetic hyperactivity. Our aim was to explore the role of Macrophage-inducible C-type lectin (Mincle) within the PVN in augmenting sympathetic activity following MI,and whether NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome/IL-1β axis is involved in this activity. MI was induced by coronary artery ligation. Mincle expression l...
Source: J Cell Mol Med - October 24, 2018 Category: Molecular Biology Authors: Wang Y, Yin J, Wang C, Hu H, Li X, Xue M, Liu J, Cheng W, Wang Y, Li Y, Shi Y, Tan J, Li X, Liu F, Liu Q, Yan S Tags: J Cell Mol Med Source Type: research

Long non-coding RNA metallothionein 1 pseudogene 3 promotes p2y12 expression by sponging miR-126 to activate platelet in diabetic animal model.
In conclusion, our findings identify MT1P3 as a key regulator in platelet activation by increasing p2y12 expression through sponging miR-126 under T2D condition. These findings may provide a new insight for managing platelet hyperactivity-related diseases. PMID: 29617185 [PubMed - as supplied by publisher]
Source: Platelets - April 6, 2018 Category: Hematology Tags: Platelets Source Type: research

Enhanced Inflammasome Activity in Systemic Lupus Erythematosus Is Mediated via Type I Interferon –Induced Up‐Regulation of Interferon Regulatory Factor 1
ConclusionProlonged type I IFN exposure, as seen in SLE patients, primes monocytes for robust inflammasome activation in an IRF‐1–dependent manner. IRF‐1 inhibition may serve as a novel target for treatment of SLE‐associated inflammation and organ damage.
Source: Arthritis and Rheumatism - August 8, 2017 Category: Rheumatology Authors: Jianhua Liu, Celine C. Berthier, J. Michelle Kahlenberg Tags: Full Length Source Type: research

Enhanced inflammasome activity in systemic lupus erythematosus is mediated via type I interferon upregulation of interferon regulatory factor 1
Conclusion: Prolonged type I IFN exposure, as seen in SLE patients, primes monocytes for robust inflammasome activation in an IRF1‐dependent manner. IRF1 inhibition may serve as a novel target for treatment of SLE‐associated inflammation and organ damage. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - May 31, 2017 Category: Rheumatology Authors: Jianhua Liu, Celine C. Berthier, J. Michelle Kahlenberg Tags: Full Length Source Type: research

Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.
Abstract Vascular smooth muscle (VSM) plays an important role in maintaining vascular tone. In addition to Ca(2+)-dependent myosin light chain (MLC) phosphorylation, protein kinase C (PKC) is a major regulator of VSM function. PKC is a family of conventional Ca(2+)-dependent α, β, and γ, novel Ca(2+)-independent δ, ɛ, θ, and η, and atypical ξ, and ι/λ isoforms. Inactive PKC is mainly cytosolic, and upon activation it undergoes phosphorylation, maturation, and translocation to the surface membrane, the nucleus, endoplasmic reticulum, and other cell organelles; a process facilitated by scaffold proteins su...
Source: Advances in Pharmacology - February 20, 2017 Category: Drugs & Pharmacology Authors: Ringvold HC, Khalil RA Tags: Adv Pharmacol Source Type: research

Luminal STAT5 mediates H2AX promoter activity in distinct population of basal mammary epithelial cells.
Authors: Reichenstein M, Rauner G, Kfir S, Kisliouk T, Barash I Abstract Deregulated STAT5 activity in the mammary gland causes parity-dependent tumorigenesis. Epithelial cell cultures transfected with constitutively active STAT5 express higher levels of the histone H2AX than their non-transfected counterparts. Higher H2AX expression may be involved in tumorigenesis. Here, we aimed to link high STAT5 activity to H2AX-GFP expression by looking for distinct types of mammary cells that express these proteins. In vitro and in transgenic mice, only 0.2 and 0.02%, respectively, of the cells expressed the H2AX-GFP hybrid ...
Source: Oncotarget - June 5, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Fluorescent peptide biosensor for monitoring CDK4/cyclin D kinase activity in melanoma cell extracts, mouse xenografts and skin biopsies
Publication date: 15 November 2016 Source:Biosensors and Bioelectronics, Volume 85 Author(s): Camille Prével, Morgan Pellerano, Juan A. González-Vera, Pauline Henri, Laurent Meunier, Julien Vollaire, Véronique Josserand, May C. Morris Melanoma constitutes the most aggressive form of skin cancer, which further metastasizes into a deadly form of cancer. The p16INK4a-Cyclin D-CDK4/6-pRb pathway is dysregulated in 90% of melanomas. CDK4/Cyclin D kinase hyperactivation, associated with mutation of CDK4, amplification of Cyclin D or loss of p16INK4a leads to increased risk of developing melanoma. This kinase therefo...
Source: Biosensors and Bioelectronics - May 17, 2016 Category: Biotechnology Source Type: research

Alpha1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC6 Channels in Cultured Human Mesangial Cells
Conclusion: TRPC6 channels are involved in α1-AR activation-induced Ca2+ entry, which mediates proliferation via ERK signaling in human MCsCell Physiol Biochem 2015;36:1928-1938
Source: Cellular Physiology and Biochemistry - July 18, 2015 Category: Cytology Source Type: research

Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β‐cells
ConclusionsSrc plays an important role in glucose‐induced insulin secretion in pancreatic β‐cells via maintaining subcellular localization and activity of glucokinase.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - July 1, 2015 Category: Endocrinology Authors: Hiroki Sato, Kazuaki Nagashima, Masahito Ogura, Yuichi Sato, Yumiko Tahara, Kasane Ogura, Gen Yamano, Kazu Sugizaki, Naotaka Fujita, Hisato Tatsuoka, Ryota Usui, Eri Mukai, Shimpei Fujimoto, Nobuya Inagaki Tags: Original Article Source Type: research

Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion
Risk factors indicate the importance of oxidative stress during ovarian carcinogenesis. To tolerate oxidative stress, cells activate the transcription factor Nrf2 (Nfe2l2), the master regulator of antioxidant and cytoprotective genes. Indeed, for most cancers, hyperactivity of Nrf2 is observed, and siRNA studies assigned Nrf2 as therapeutic target. However, the cancer-protective role of Nrf2 in healthy cells highlights the requirement for an adequate therapeutic window. We engineered artificial transcription factors to assess the role of Nrf2 in healthy (OSE-C2) and malignant ovarian cells (A2780).
Source: Molecular Oncology - March 21, 2015 Category: Cancer & Oncology Authors: Monique G.P. van der Wijst, Christian Huisman, Archibold Mposhi, Gerard Roelfes, Marianne G. Rots Source Type: research

Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo.
Abstract Although cancer vaccine-based immunotherapy holds great potential for cancer treatment, tumor-induced dendritic cell (DC) dysfunction remains to be the major obstacle for developing effective vaccines. Compared with normal DCs, tumor-associated DCs (TADCs) are less matured with poor responsiveness to Toll-like receptor (TLR) stimulation, which has been related with STAT3 hyperactivity. In the present study, Poly I:C (PIC, a TLR3 agonist), STAT3 siRNA and OVA antigen were co-encapsulated by poly (ethylene glycol)-b-poly (l-lysine)-b-poly (l-leucine) (PEG-PLL-PLLeu) polypeptide micelles to generate PMP/OVA/...
Source: Biomaterials - December 6, 2014 Category: Materials Science Authors: Luo Z, Wang C, Yi H, Li P, Pan H, Liu L, Cai L, Ma Y Tags: Biomaterials Source Type: research

Mineralocorticoid and angiotensin II type 1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarction.
This article is protected by copyright. All rights reserved. PMID: 24951624 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 20, 2014 Category: Physiology Authors: Huang BS, Chen A, Ahmad M, Wang HW, Leenen FH Tags: J Physiol Source Type: research