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Adapalene induces adipose browning through the RAR β-p38 MAPK-ATF2 pathway
This study identifies new actions of AD as an adipose browning agent and demonstrates that RARβ activation followed by increased phosphorylation of p38 MAPK and ATF2 appears to be a key mechanism of AD action.PMID:35608792 | DOI:10.1007/s12272-022-01384-4
Source: Archives of Pharmacal Research - May 24, 2022 Category: Drugs & Pharmacology Authors: Na Hyun Lee Mi Jin Choi Hana Yu Jea Il Kim Hyae Gyeong Cheon Source Type: research

Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2 ).
Abstract Nicotinic acid (NA) activates hydroxycarboxylic acid receptor 2 (HCA2 ), and it is widely used in treating dyslipidaemias. Since its side effects include skin dryness, whereas its deficiency can be accompanied by dyssebacia, characterized by sebaceous gland enlargement, we asked if HCA2 is expressed on human sebocytes, and if NA influences sebocyte functions. By using human immortalized SZ95 sebocytes, we found that non-cytotoxic (≤100 μmol/L; MTT-assay) concentrations of NA had no effect on the homeostatic sebaceous lipogenesis (SLG; Nile Red), but normalized excessive, acne-mimicking SLG induced by ...
Source: J Cell Mol Med - July 4, 2019 Category: Molecular Biology Authors: Markovics A, Tóth KF, Sós KE, Magi J, Gyöngyösi A, Benyó Z, Zouboulis CC, Bíró T, Oláh A Tags: J Cell Mol Med Source Type: research

Current non-viral siRNA delivery systems as a promissing treatment of skin diseases.
CONCLUSION: The treatment of skin diseases based on topical delivery of siRNA, which act by inhibiting the expression of target transcripts, offers many potential therapeutic advantages for suppressing genes into the skin. PMID: 30084329 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 7, 2018 Category: Drugs & Pharmacology Authors: Rosa J, Suzuki I, Kravicz M, Caron A, Pupo AV, Praca FG, Bentley MVLB Tags: Curr Pharm Des Source Type: research

G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes.
Conclusion: G2A may play a role in quelling inflammatory cytokine response to PA, revealing G2A as a potential attenuator of inflammatory response in a disease associated with a commensal bacterium. PMID: 29200756 [PubMed]
Source: Annals of Dermatology - December 5, 2017 Category: Dermatology Tags: Ann Dermatol Source Type: research

MiR-338-3p inhibits TNF- α-induced lipogenesis in human sebocytes.
CONCLUSIONS: MiR-338-3p suppresses the TNF-α-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K/AKT signaling. PMID: 28597147 [PubMed - as supplied by publisher]
Source: Biotechnology Letters - June 9, 2017 Category: Biotechnology Authors: Liu J, Cao L, Feng Y, Li Y, Li T Tags: Biotechnol Lett Source Type: research

Srb1 as a new redox target of cigarette smoke in human sebocytes.
In conclusion, exposure to CS, induced SRB1 post-translational modifications in sebocytes and this might affect sebocytes/skin functionality. PMID: 27865981 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - November 15, 2016 Category: Biology Authors: Crivellari I, Sticozzi C, Belmonte G, Muresan XM, Cervellati F, Pecorelli A, Cavicchio C, Maioli E, Zouboulis CC, Benedusi M, Cervellati C, Valacchi G Tags: Free Radic Biol Med Source Type: research

Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through Notch and PI3K-AKT signaling pathways.
CONCLUSIONS: Deficiency of nicastrin gene in familial acne inversa may regulate proliferation and differentiation of keratinocytes mainly through Notch and PI3K-AKT signaling pathways. This article is protected by copyright. All rights reserved. PMID: 26473517 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - October 16, 2015 Category: Dermatology Authors: Xiao X, He Y, Li C, Zhang X, Xu H, Wang B Tags: Br J Dermatol Source Type: research

Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through Notch and PI3K‐AKT signaling pathways
ConclusionsDeficiency of nicastrin gene in familial acne inversa may regulate proliferation and differentiation of keratinocytes mainly through Notch and PI3K‐AKT signaling pathways.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - October 16, 2015 Category: Dermatology Authors: X. Xiao, Y. He, C. Li, X. Zhang, H. Xu, B. Wang Tags: Original Article Source Type: research

Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis.
Abstract Lipid metabolism depends on lipid droplets (LD), cytoplasmic structures surrounded by a protein-rich phospholipid monolayer. Although lipid synthesis is the hallmark of sebaceous gland cell differentiation, the LD-associated proteins of sebocytes have not been evaluated systematically. The LD fraction of SZ95 sebocytes was collected by density gradient centrifugation and associated proteins were analyzed by nanoliquid chromatography/tandem mass spectrometry. 54 proteins were significantly enriched in LD fractions, and 6 of them have not been detected previously in LDs. LD fractions contained high levels o...
Source: Experimental Cell Research - December 16, 2014 Category: Cytology Authors: Dahlhoff M, Fröhlich T, Arnold GJ, Müller U, Leonhardt H, Zouboulis CC, Schneider MR Tags: Exp Cell Res Source Type: research