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Specialty: Biochemistry
Condition: Heart Disease

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Total 34 results found since Jan 2013.

Combined Application of Human Amniotic Membrane Mesenchymal Stem Cells and a Modified PGS-co-PCL Film in an Experimental Model of Myocardial Ischemia-Reperfusion Injury
Appl Biochem Biotechnol. 2023 Apr 3. doi: 10.1007/s12010-023-04446-5. Online ahead of print.ABSTRACTAccording to the World Health Organization (WHO), about 3.9 million people die annually of ischemic heart disease (IHD). Several clinical trials have shown that stem cell therapy is a promising therapeutic approach to IHD. Human amniotic membrane mesenchymal stem cells (hAMSCs) positively affect the repair of myocardial ischemia-reperfusion (MI/R) injury by stimulating endogenous repair mechanisms. The differentiated hAMSCs with and without modified PGS-co-PCL film were applied in the myocardium. MI/R injury was induced by l...
Source: Applied Biochemistry and Biotechnology - April 3, 2023 Category: Biochemistry Authors: Nastaran Bahrami Mahsa Ale-Ebrahim Yasin Asadi Nooshin Barikrow Ali Salimi Fatemeh Roholah Source Type: research

Exploring the role of lipoprotein(a) in cardiovascular diseases and diabetes in Chinese population
Int J Biol Macromol. 2023 Feb 7:123586. doi: 10.1016/j.ijbiomac.2023.123586. Online ahead of print.ABSTRACTA high level of lipoprotein (a) in the plasma has been associated with a variety of cardiovascular diseases and is considered to be an independent predictor of some other diseases. Based on recent studies, the concentration levels of Lp(a) in the Chinese population exhibit a distinctive variation from other populations. In the Chinese population, a high level of Lp(a) indicates a higher incidence of revascularization, platelet aggregation, and thrombogenicity following PCI. Increased risk of atherosclerotic cardiovasc...
Source: International Journal of Biological Macromolecules - February 9, 2023 Category: Biochemistry Authors: Zubair Hussain Hongcai Liu Junaid Iqbal Hou-De Zhou Source Type: research

Protein-based HDL subspecies: Rationale and association with cardiovascular disease, diabetes, stroke, and dementia
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 May 20:159182. doi: 10.1016/j.bbalip.2022.159182. Online ahead of print.ABSTRACTHDL-cholesterol is associated with reduced risk of cardiovascular disease, and is used in clinical practice for risk stratification. HDL is composed of many protein-defined subspecies that each comprises just a few percent of the total, some associated with lower and some with higher risk of CVD. HDL that contains apoC3 and apoE are subspecies that have opposing actions on HDL reverse cholesterol transport and opposing associations with risk of future CVD, apoC3 adverse and apoE beneficial. In add...
Source: Biochimica et Biophysica Acta - May 23, 2022 Category: Biochemistry Authors: F M Sacks J D Furtado M K Jensen Source Type: research

Temporal proteomic changes induced by nicotine in human cells: A quantitative proteomics approach
J Proteomics. 2021 Apr 22:104244. doi: 10.1016/j.jprot.2021.104244. Online ahead of print.ABSTRACTNicotine is a prominent active compound in tobacco and many smoking cessation products. Some of the biological effects of nicotine are well documented in in vitro and in vivo systems; however, nominal data are available concerning the time-dependent changes on protein and phosphorylation events in response to nicotine. Here, we profiled the proteomes of SH-SY5Y and A549 cell lines subjected to acute (15 min, 1 h and 4 h) or chronic (24 h, 48 h) nicotine exposures. We used sample multiplexing (TMTpro16) and quantified more than...
Source: Journal of Proteomics - April 25, 2021 Category: Biochemistry Authors: Jos é Navarrete-Perea Steven P Gygi Joao A Paulo Source Type: research

Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study
CONCLUSION: Concentrations of cTnI measured with a very high sensitivity assay are predictive of carotid atherosclerotic burden, a phenomenon likely attributable to common risk factors of subclinical myocardial injury, coronary and carotid atherosclerosis.PMID:33861986 | DOI:10.1016/j.clinbiochem.2021.04.005
Source: Clinical Biochemistry - April 16, 2021 Category: Biochemistry Authors: Magnus Nakrem Lyngbakken Thea Vigen H åkon Ihle-Hansen Jon Brynildsen Trygve Berge Ole Morten R ønning Arnljot Tveit Helge R øsjø Torbj ørn Omland Source Type: research

Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis.
Abstract Atherosclerosis results in life-threatening cardiovascular pathologies, including ischemic heart disease, stroke, myocardial infarction, and peripheral arterial disease. The role of increased serum low-density lipoprotein (LDL) and resultant accumulation of oxidized-LDL (oxLDL) in atheroma formation is well established. Recent findings elucidate the significance of mitochondrial damage-associated molecular patterns (mtDAMPs) in triggering sterile inflammation in concert with oxLDL. The mtDAMPs including mitochondrial DNA (mtDNA), cytochrome C, cardiolipin, heat shock protein 60 (HSP60), mitochondrial tran...
Source: Molecular and Cellular Biochemistry - January 25, 2021 Category: Biochemistry Authors: Khwaja B, Thankam FG, Agrawal DK Tags: Mol Cell Biochem Source Type: research

Effects of air pollution particles (ultrafine and fine particulate matter) on mitochondrial function and oxidative stress - Implications for cardiovascular and neurodegenerative diseases.
Abstract Environmental pollution is a major cause of global mortality and burden of disease. All chemical pollution forms together may be responsible for up to 12 million annual excess deaths as estimated by the Lancet Commission on pollution and health as well as the World Health Organization. Ambient air pollution by particulate matter (PM) and ozone was found to be associated with an all-cause mortality rate of up to 9 million in the year 2015, with the majority being of cerebro- and cardiovascular nature (e.g. stroke and ischemic heart disease). Recent evidence suggests that exposure to airborne particles and ...
Source: Archives of Biochemistry and Biophysics - November 4, 2020 Category: Biochemistry Authors: Daiber A, Kuntic M, Hahad O, Delogu LG, Rohrbach S, Di Lisa F, Schulz R, Münzel T Tags: Arch Biochem Biophys Source Type: research

Nanodomains in cardiopulmonary disorders and the impact of air pollution.
Abstract Air pollution is a major environmental threat and each year about 7 million people reported to die as a result of air pollution. Consequently, exposure to air pollution is linked to increased morbidity and mortality world-wide. Diesel automotive engines are a major source of urban air pollution in the western societies encompassing particulate matter and diesel exhaust particles (DEP). Air pollution is envisioned as primary cause for cardiovascular dysfunction, such as ischemic heart disease, cardiac dysrhythmias, heart failure, cerebrovascular disease and stroke. Air pollution also causes lung dysfunctio...
Source: Biochemical Society Transactions - June 28, 2020 Category: Biochemistry Authors: Cattani-Cavalieri I, Valença SDS, Schmidt M Tags: Biochem Soc Trans Source Type: research

Paraoxonase 1 and atherosclerosis ‐related diseases
AbstractA direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high ‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti‐inflammatory, antiapoptotic, v asodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affe...
Source: BioFactors - August 9, 2019 Category: Biochemistry Authors: Jelena Kotur ‐Stevuljević, Jelena Vekić, Aleksandra Stefanović, Aleksandra Zeljković, Ana Ninić, Jasmina Ivanišević, Milica Miljković, Miron Sopić, Jelena Munjas, Marija Mihajlović, Slavica Spasić, Zorana Jelić‐Ivanović, Vesna Tags: REVIEW ARTICLE Source Type: research